首页工具

登录

搜索结果

Search Results for " mglu2 "

31

抑制剂 & 化合物

1

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T15812	LY2979165 mGlu2 agonist	GluR	Neuroscience
	LY2979165 (mGlu2 agonist) 是 mGluR2 的正构激动剂，可用于作为抗抑郁药的研究。
T6022	LY404039 pomaglumetad	Glucocorticoid Receptor; GluR	Endocrinology/Hormones; Neuroscience
	LY404039 (pomaglumetad) 是可口服的mGluR2和mGluR3选择性激动剂，有抗精神病和抗焦虑的作用。它对重组人mGluR2和mGluR3的Ki 分别为 149 和 92 nM，比对其他受体/转运蛋白的抑制性高 100 倍以上。
T3451	JNJ-42153605	GluR	Neuroscience
	JNJ42153605是一种代谢型谷氨酸2 (mGlu2) 受体的正变构调节剂，EC50值为17 nM。
T23010	MNI 137	Others; GluR	Neuroscience; Others
	MNI 137 是 mGlu2 的负变构调节剂。 MNI 137 抑制谷氨酸诱导的钙动员，对人和大鼠的 IC50 分别为 8.3 和 12.6 nM。
T22638	CBiPES hydrochloride CBiPES HCl	GluR	Neuroscience
	CBiPES hydrochloride(CBiPES HCl) 是一种高效的 mGlu2 受体正变构调节剂，EC50值为 92.8 nM。CBiPES hydrochloride 可阻断 WT 和 mGlu（3）受体的作用。CBiPES hydrochloride 可用于研究像癫痫和帕金森综合征类的神经系统疾病。
T20941	Cloransulam-methyl Cloransulam methyl	Others	Others
	Cloransulam-methyl 是一种有效的除草剂，常施用于大豆田来防治阔叶杂草。Cloransulam-methyl会在大豆植物中很快代谢掉，却会在土壤中存在。
T23000	ML289 VU0463597,ML 289	GluR	Neuroscience
	ML289 (VU0463597)是一种高效、选择性的，可透过血脑屏障的 mGlu3 (IC50=0.66 μM) 负变构调节剂。ML289 的选择性是 mGlu2 的 15 倍，对 mGlu5 无活性。
T61972	Pomaglumetad methionil hydrochloride LY2140023 hydrochloride	GluR	Neuroscience
	Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) (LY2140023 hydrochloride) 是的 LY404039 的蛋氨酸前药，具有口服活性。LY404039是一种选择性 mGlu2/3 受体激动剂。Pomaglumetad methionil hydrochloride 可用于精神分裂症的研究。
T6726	VU0361737 ML-128,VU 0361737	GluR	Neuroscience
	VU0361737 (ML-128) 是一种高效选择性的，中枢神经系统渗透性的代谢型谷氨酸受体 4(mGluR4)正变构调节剂，对人类和大鼠 mGluR4作用的EC50值分别为 240 和 110 nM。它具有神经保护作用，有用于帕金森氏病的研究潜力。
TQ0094	JNJ-40411813 ADX-71149	GluR	Neuroscience
	JNJ-40411813 (ADX-71149) 是一种新型 mGlu2R 正变构调节剂，EC50 值为 147 nM。
T28928	TASP0433864
	TASP0433864 is a positive allosteric modulator of metabotropic glutamate 2 receptor with EC50 values of 199 and 206 nM at human and rat mGlu2 receptors, respectively, without exerting agonist activity at rat mGlu2 receptor.
T23247	Ro 64-5229	Others	Others
	mGlu2 antagonist
T27686	JNJ-46356479 JNJ 46356479
	JNJ-46356479 is a Selective and Orally Bioavailable mGlu2 receptor Positive Allosteric Modulator (PAM). JNJ-46356479 showed mGlu2 PAM EC50=78 nM; mGlu2 PAM Emax (%) = 256.
T15809	LY2812223	LIM Kinase	Cell Cycle/Checkpoint
	LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).
T15817	Eglumegad Eglumetad,LY354740	Others	Others
	Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).
T22955	LY487379 hydrochloride LY 487379 hydrochloride	Others	Others
	Positive allosteric modulator of mGlu2 receptors
T29142	VU6001966 VU 6001966,VU-6001966
	VU6001966 is a potent and selective mGlu2 inhibitor (mGlu2 IC50 = 78 nM) and negative allosteric modulator. VU6001966 exhibits excellent central nervous system (CNS) penetration.
T29141	VU6001192 VU 6001192,VU-6001192
	VU6001192 is a negative allosteric modulator of mGlu2.
T34376	RO5488608 RO 5488608,RO-5488608
	RO5488608 is a new type of high-efficiency mGlu2/3 NAM.
T27950	LY389795 LY-389795,LY 389795
	LY389795 is an agonist of group II (mGlu2/3) metabotropic glutamate receptor, it is used in inflammatory pain models.
T27680	JNJ-40068782 JNJ 40068782
	JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.
T11911	LY3020371 hydrochloride	GluR	Neuroscience
	LY3020371 hydrochloride exerts an antidepressant-like signature in vivo. LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM.
T12520	Pomaglumetad methionil LY2140023 hydrate	GluR	Neuroscience
	Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.
T70619	LY2934747
	LY2934747 is a novel, potent, and systemically bioavailable mGlu2/3 receptor agonist, exhibiting both antipsychotic and analgesic properties in vivo.
T38792	LY3027788 LY3027788
	LY3027788, a diester analog of LY3020371, an mGlu2/3 receptor antagonist, is a highly potent and orally active prodrug of LY3020371. Notably, LY3027788 exhibits significant antidepressant efficacy.
T78094	Eglumegad hydrochloride LY354740 hydrochloride,Eglumetad hydrochloride
	Eglumegad (LY354740) hydrochloride是一种高效且选择性的group II (mGlu2/3) receptor激动剂，其对人mGlu2和mGlu3受体的IC50值分别是5和24 nM。该化合物能够保护神经元不受NMDA毒性影响，并表现出抗焦虑及抗精神病样作用。
T62756	LY487379
	LY487379是一种选择性的人类 mGluR2 阳性异生调节剂（PAM）。LY487379 可提高谷氨酸刺激的 [35 S] GTPγS 结合，作用于 mGlu2 受体 (EC50: 1.7 μM) 和 mGlu3 受体 (EC50>10 μM)。LY487379 在大鼠模型中促使认知的灵活性，并诱导行为抑制。LY487379 能够用于研究精神分裂症。
T11906	LY 541850	GluR	Neuroscience
	LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells.
T38790	LY3027788 hydrochloride
	LY3027788 hydrochloride is a diester analog of LY3020371, a selective antagonist of the metabotropic glutamate 2 and 3 receptors (mGlu2/3). It serves as a highly potent and orally bioavailable prodrug of LY3020371. Notably, LY3027788 hydrochloride exhibits antidepressant efficacy.
T71764	YM 298198 Hydrochloride
	YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM). YM 298198 Hydrochloride is inactive at other mGlu receptor subtypes (mGlu2-7), ionotropic receptors and glutamate transporters (IC50 > 10 μM). It inhibits glutamate-induced IP production more potently than CPCCOEt (IC50 values are 16 nM and 6.3 μM respectively).
T71262	AZD-8418
	AZD-8418 is an mGlu2 receptor positive allosteric modulators that attenuates nicotine-taking and nicotine-seeking behavior. Acute treatment with AZD8418 (0.37, 1.12, 3.73, 7.46, and 14.92 mg/kg) and AZD8529 (1.75, 5.83, 17.5, and 58.3 mg/kg) deceased nicotine self-administration and had no effect on food-maintained responding. Chronic treatment with AZD8418 attenuated nicotine self-administration, but tolerance to this effect developed quickly. The inhibition of nicotine self-administration by c...

化合物

Cat.No: T15812

Synonym: mGlu2 agonist

Target: GluR

Cat.No: T6022

Synonym: pomaglumetad

Target: Glucocorticoid Receptor, GluR

Cat.No: T3451

Target: GluR

Cat.No: T23010

Target: Others, GluR

CBiPES hydrochloride

Cat.No: T22638

Synonym: CBiPES HCl

Target: GluR

Cloransulam-methyl

Cat.No: T20941

Synonym: Cloransulam methyl

Target: Others

Cat.No: T23000

Synonym: VU0463597,ML 289

Target: GluR

Pomaglumetad methionil hydrochloride

Cat.No: T61972

Synonym: LY2140023 hydrochloride

Target: GluR

Cat.No: T6726

Synonym: ML-128,VU 0361737

Target: GluR

Cat.No: TQ0094

Synonym: ADX-71149

Target: GluR

Cat.No: T28928

Cat.No: T23247

Target: Others

Cat.No: T27686

Synonym: JNJ 46356479

Cat.No: T15809

Target: LIM Kinase

Cat.No: T15817

Synonym: Eglumetad,LY354740

Target: Others

LY487379 hydrochloride

Cat.No: T22955

Synonym: LY 487379 hydrochloride

Target: Others

Cat.No: T29142

Synonym: VU 6001966,VU-6001966

Cat.No: T29141

Synonym: VU 6001192,VU-6001192

Cat.No: T34376

Synonym: RO 5488608,RO-5488608

Cat.No: T27950

Synonym: LY-389795,LY 389795

Cat.No: T27680

Synonym: JNJ 40068782

LY3020371 hydrochloride

Cat.No: T11911

Target: GluR

Pomaglumetad methionil

Cat.No: T12520

Synonym: LY2140023 hydrate

Target: GluR

Cat.No: T70619

Cat.No: T38792

Synonym: LY3027788

Eglumegad hydrochloride

Cat.No: T78094

Synonym: LY354740 hydrochloride,Eglumetad hydrochloride

Cat.No: T62756

Cat.No: T11906

Target: GluR

LY3027788 hydrochloride

Cat.No: T38790

YM 298198 Hydrochloride

Cat.No: T71764

Cat.No: T71262

Cat. No.	Product Name	Target	Signaling Pathways
T3010	Xanthurenic Acid 8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate	Apoptosis; Endogenous Metabolite; GluR	Apoptosis; Metabolism; Neuroscience
	Xanthurenic Acid (8-Hydroxykynurenic acid) 是通过 3-羟基犬尿氨酸转氨而由色氨酸代谢产生的分子，可激活 mGlu2/3 代谢型谷氨酸受体。在下丘脑的感觉传输过程中，它被认为是Group II 代谢型谷氨酸受体的激动剂。

天然产物

Xanthurenic Acid

Cat.No: T3010

Synonym: 8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate

Target: Apoptosis, Endogenous Metabolite, GluR

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼