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Cat. No.	Product Name	Target	Signaling Pathways
T9072	Tuxobertinib BDTX-189	EGFR; HER; BTK; RIP kinase	Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂，具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。
T64124	Sunvozertinib DZD9008,DZD 9008,DZD-9008	EGFR; BTK	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Sunvozertinib (DZD9008) 是一种有效的 ErbBs 和 BTK 抑制剂，对EGFR、Her2和突变型表皮生长因子有抑制作用。 Sunvozertinib 显示 EGFR 外显子 20 NPH 插入、EGFR 外显子 20 ASV 插入、EGFR L858R 和 T790M 突变以及 Her2 外显子 20 YVMA 和 EGFR WT A431 有抑制作用， IC50 分别为 20.4、20.4、1.1、7.5 和 80.4 nM 。
T31932	GJ071 oxalate GJ 071,GJ-071,GJ071	Others	Others
	GJ071 oxalate 是一种无义抑制剂。无义抑制剂（NonSups）诱导“读出”，即在提前终止密码子处选择近同源tRNA，并将相应的氨基酸插入新生多肽中。
T35901	EGFR-IN-99 JBJ-03-142-02	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-99 (JBJ-03-142-02) 是一种 EGFR 和 HER2 Exon 20 插入突变抑制剂，具有抗增殖活性，可用于研究非小细胞肺癌 (NSCLC) 。
T31011	Coralyne chloride	Topoisomerase	DNA Damage/DNA Repair
	Coralyne chloride 是一种具有强抗癌活性的原小檗碱。它可用于制备 Coralyne 衍生物，是一种基于荧光 DNA 的分子整流剂，通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。
TP1573L	CLIP 86-100 acetate(648881-58-7 free base)	Others	Others
	CLIP 86-100 acetate(648881-58-7 free base) 这是称为 CLIP 的 II 类相关不变链肽的氨基酸 86 至 100 片段。主要组织相容性复合物 II 类分子显示外源蛋白的肽片段，以触发免疫系统的防御反应。在将外源肽插入结合槽之前，去除一个占位肽 CLIP。这是通过分子 DM 实现的，它被证明可以增加 CLIP 肽与 II 类的解离速率。
T31933	GJ072 GJ-072,GJ 072
	GJ-072 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide.
T9304	(S)-Sunvozertinib N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(S)-Sunvozertinib (DZD9008) 是 Sunvozertinib 的 S-对映体，能够抑制EGFR 外显子 20 NPH 和 ASV 插入、EGFR L858R/T790M 突变及 Her2 外显子 20 YVMA 插入，也能够抑制BTK。
T63792	LDC0496
	LDC0496 是 EGFR 的有效抑制剂。LDC0496 能够显著抑制 EGFR 和 Her2 外显子 20 插入突变，并对野生型 EGFR 和激酶组内的选择性。
T71991	PUN-96956
	PUN-96956 is a novel BAM complex inhibitor, interfering with BamA-related processes and affect folding and insertion of OMPs. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).
TP1573	CLIP (86-100) CLIP 86-100
	CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide called CLIP. The major histocompatibility complex class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the binding groove, a place-holding peptide CLIP is removed. CLIP (86-100) is accomplished by the molecule DM, which is shown to increase the dissociation rate of a CLIP peptide from class...
T60997	GL0388
	GL0388 是一种Bax 激活剂，可导致 Bax 插入线粒体膜，从而诱导 Bax 介导的细胞凋亡。GL0388 在体内抑制乳腺癌异种移植的肿瘤生长，并且对多种癌细胞表现出抗增殖活性，IC50值为 0.299-1.57 μM。
T69498	DBPR112 HCl
	DBPR112 is a potent EGFR inhibitor (IC50=487 nM) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer. DBPR112), DBPR112 not only displayed a potent inhibitory activity against EGFRL858R/T790M double mutations but also exhibited tenfold potency better than the third-generation inhibitor, osimertinib,against EGFR and HER2 exon 20 insertion mutations. Overall, pharmacokinetic improvement through lead-to-candidate optimization yielded fourfold oral AUC better that afatinib alon...
T37862	9(R)-HODE
	9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) configuration at the site of oxygen insertion. However, both human umbilical vein endothelial cells and bovine aorta endothelial cells have been shown to produce 9(R)-HODE when incubated with linoleic acid. The physiological function of 9(R)-HODE and the enzyme that catalyzes its form...
T63573	WF-47-JS03
	WF-47-JS03 是选择性的、有效的、能够透过血脑屏障的 RET 激酶抑制剂，比对激酶插入域受体 (KDR) 的选择性高 500 多倍。WF-47-JS03 作用于转染 KIF5B-RET 的 Ba/F3 细胞 (IC50: 1.7 nM) 和转染 CCDC6-RET 的 LC-2/ad 肺癌细胞 (IC50: 5.3 nM)。
T38356	1,2-Dipalmitoyl-13C-sn-glycero-3-PC
	1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation...

化合物

Cat.No: T9072

Synonym: BDTX-189

Target: EGFR, HER, BTK, RIP kinase

Cat.No: T64124

Synonym: DZD9008,DZD 9008,DZD-9008

Target: EGFR, BTK

Cat.No: T31932

Synonym: GJ 071,GJ-071,GJ071

Target: Others

Cat.No: T35901

Synonym: JBJ-03-142-02

Target: EGFR, HER

Coralyne chloride

Cat.No: T31011

Target: Topoisomerase

CLIP 86-100 acetate(648881-58-7 free base)

Cat.No: TP1573L

Target: Others

Cat.No: T31933

Synonym: GJ-072,GJ 072

(S)-Sunvozertinib

Cat.No: T9304

Synonym: N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide,DZD9008

Target: EGFR, HER

Cat.No: T63792

Cat.No: T71991

Cat.No: TP1573

Synonym: CLIP 86-100

Cat.No: T60997

Cat.No: T69498

Cat.No: T37862

Cat.No: T63573

1,2-Dipalmitoyl-13C-sn-glycero-3-PC

Cat.No: T38356

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