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Cat. No.	Product Name	Target	Signaling Pathways
T1414	Sodium 2-mercaptoethanesulfonate Mitexan,美司那,美司钠,Uromitexan,Mesna,Mesnum,Mesnex	Others	Others
	Sodium 2-mercaptoethanesulfonate (Uromitexan) 是一种抗氧化剂，具有细胞保护作用。它可用于减轻由环磷酰胺引起的出血性膀胱炎。它广泛用作抗化学疗法毒性的全身保护剂。
T11281L	FGI-106 tetrahydrochloride	Virus Protease; HCV Protease; Influenza Virus; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	FGI-106 tetrahydrochloride 对多种病毒具有抑制活性，有抗埃博拉病毒，裂谷病毒和登革热病毒的 EC50分别为 100 nM，800 nM 和 400-900 nM，抑制非失血性发热病毒HCV 和HIV-1的EC50分别为 200 nM 和 150 nM 。
T38238	2'-Deoxy-2'-fluorocytidine	Nucleoside Antimetabolite/Analog; Influenza Virus	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	2'-Deoxy-2'-fluorocytidine 是一种核苷类似物，可有效抑制刚果出血热病毒的复制。2'-Deoxy-2'-fluorocytidine 与 T705 的协同作用会增强对CCHFV 复制的抵抗效力。
T5963	Menadione bisulfite sodium Sodium menadione bisulfite,亚硫酸氢钠甲萘醌,Menadione sodium bisulfite,Vitamin K3 sodium bisulfite	Others	Others
	Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) 是可以诱导急性氧化应激的试剂，可用作植物防御活化剂，具有抵抗病菌的作用。
T12001	Menaquinone-7 Vitamin MK-7,维生素 K2(35),Vitamin K2-7,Vitamin K2(35)	Others	Others
	Menaquinone-7 (Vitamin K2(35)) 是一种最早作为抗出血因子被发现的维生素K2家族成员。它是Gla-蛋白羧化反应中最具生物活性的辅因子，补充它也是激活Gla 基质蛋白并干预钙化性主动脉瓣狭窄(CAVS)进展的一种药理选择。
T21967	MEG hemisulfate Mercaptoethylguanidine hemisulfate	NOS	Immunology/Inflammation
	MEG hemisulfate (Mercaptoethylguanidine hemisulfate) 是一种有效和选择性的诱导型 NO 合酶 (iNOS) 的抑制剂，在组织匀浆中抑制 iNOS，ecNOS 和 bNOS 的 EC50 值分别为 11.5，110 和 60 μM。MEG hemisulfate 也有效的过氧亚硝酸盐清除剂，可抑制过氧亚硝酸盐诱导的氧化过程。MEG hemisulfate 在许多炎症实验模型中具有保护作用，包括缺血/再灌注损伤，牙周炎，失血性休克，炎性肠病以及内毒素和败血性休克。
T27590	IHVR-11029 IHVR 11029
	IHVR-11029 is a potent inhibitor of ER α-glucosidase. IHVR-11029 is active against multiple hemorrhagic fever viruses and efficiently disrupts the morphogenesis of a broad spectrum of enveloped viruses.
T31564	Dopamine, lys-pro-amide-
	Dopamine, lys-pro-amide- is equieffective to dopamine as to its protective activity against hemorrhagic shock.
T26589	Albifylline
	Albifylline is a xanthine derivates with anti-asthmatic activity. Albifylline may cause a significant reduction of shock-induced leukocyte adhesions to the sinusoidal endothelium in the liver after hemorrhagic shock. Albifylline also improves microvascula
T27050	CM-10-18 CM-1018
	CM-10-18 is a potent inhibitor of ER α-glucosidase. CM-10-18 demonstrated superior in vitro antiviral activity against representative viruses from four viral families causing hemorrhagic fever. CM-10-18 efficiently protected the lethality of dengue virus
T77140	Ralpancizumab
	Ralpancizumab 是一种 PCSK9选择性抑制剂，在出血性中风中有潜在应用。
T80341	Seabream hepcidin
	Seabream hepcidin是一种抗菌肽，具有针对细菌(V.anguillarum)、真菌(S.cerevisiae)以及病毒性出血性败血症病毒的活性。
T15554	IHVR-19029	Others	Others
	IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Ebola virus, Dengue virus, and Rift
T77166	Rovelizumab
	Rovelizumab是一种针对CD11/CD18细胞粘附蛋白的人源化单克隆抗白细胞整合素抗体，主要用于多发性硬化症(MS)、失血性休克、心肌梗死(MI)和中风研究。
T70838	RO27-3225 TFA
	RO27-3225, also known as RO273225 is a melanocortin type 4 receptor agonist with EC50 = 1 nM. It may alleviate intestinal dysfuntion and brain damage. It has been investigated for an anti-obesity medication. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.
T11281	FGI-106	Others	Others
	FGI-106 is a potent, broad-spectrum inhibitor demonstrating activity against various viruses, including Ebola, Rift Valley Fever, and Dengue Fever, exhibiting EC50 values of 100 nM, 800 nM, and 400-900 nM, respectively. Furthermore, it effectively inhibits non-hemorrhagic fever viruses such as HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively.
T78586	Ac-IETD-CHO	Apoptosis	Apoptosis
	Ac-IETD-CHO是一种针对granzyme B和caspase 8的有效可逆抑制剂，能够阻止Fas介导的(Apoptosis)、出血和肝衰竭，并且能够抑制细胞毒性T淋巴细胞引发的细胞死亡。
T80154	TAT-CIRP
	TAT-CIRP为小肽，指Tat融合的冷诱导RNA结合蛋白。作为骨髓分化蛋白2（MD2）的抑制剂，该化合物对小鼠缺血性及出血性中风显示出显著的神经保护效果。
T75847	PG-931 TFA
	PG-931 TFA 是 SHU 9119 的类似物。PG-931 TFA 是一种强效的黑素皮质素 4 (MC4) 受体(IC50=0.58 nM) 激动剂，比 hMC3R (IC50=55 nM) 或 hMC5R (IC50=2.4 nM)更具选择性。PG-931 TFA 在动物实验模型中，可逆转出血休克，防止体内多器官损伤。
TP2184	matrix protein (3-15) [Zaire ebolavirus]	Others	Others
	matrix protein (3-15) [Zaire ebolavirus] is a peptide of the structural proteins linking the viral envelope with the zaire ebolavirus core. Ebola virus (EBOV) is a member of the family Filoviridae in the order Mononegavirales. It is the causative agent of
T38043	Resolvin E4
	Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediatesin vitroand by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism...
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

化合物

Sodium 2-mercaptoethanesulfonate

Cat.No: T1414

Synonym: Mitexan,美司那,美司钠,Uromitexan,Mesna,Mesnum,Mesnex

Target: Others

FGI-106 tetrahydrochloride

Cat.No: T11281L

Target: Virus Protease, HCV Protease, Influenza Virus, HIV Protease

2'-Deoxy-2'-fluorocytidine

Cat.No: T38238

Target: Nucleoside Antimetabolite/Analog, Influenza Virus

Menadione bisulfite sodium

Cat.No: T5963

Synonym: Sodium menadione bisulfite,亚硫酸氢钠甲萘醌,Menadione sodium bisulfite,Vitamin K3 sodium bisulfite

Target: Others

Cat.No: T12001

Synonym: Vitamin MK-7,维生素 K2(35),Vitamin K2-7,Vitamin K2(35)

Target: Others

MEG hemisulfate

Cat.No: T21967

Synonym: Mercaptoethylguanidine hemisulfate

Target: NOS

Cat.No: T27590

Synonym: IHVR 11029

Dopamine, lys-pro-amide-

Cat.No: T31564

Cat.No: T26589

Cat.No: T27050

Synonym: CM-1018

Cat.No: T77140

Seabream hepcidin

Cat.No: T80341

Cat.No: T15554

Target: Others

Cat.No: T77166

Cat.No: T70838

Cat.No: T11281

Target: Others

Cat.No: T78586

Target: Apoptosis

Cat.No: T80154

Cat.No: T75847

matrix protein (3-15) [Zaire ebolavirus]

Cat.No: TP2184

Target: Others

Cat.No: T38043

Cat.No: T38297

Synonym: Ribavirin-13C5

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