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13

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T34406	RS 0481 RS-0481,RS0481
	RS 0481 can re-establish the function of certain lymphoid cell populations impaired by the presence of a growing tumor in an animal.
T8135	Minoxidil sulfate Minoxidil sulphate,U-58838,米诺地尔硫酸盐	Potassium Channel	Membrane transporter/Ion channel
	Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物，是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂，在动物实验模型中，促进头发生长。
T38376	2-O-(α-D-Glucopyranosyl)glycerol 2-alphaGG	Others	Others
	2-O-(α-D-Glucopyranosyl)glycerol (2-alphaGG) 存在于少数细菌和生长在恶劣环境中的植物中，可通过增加渗透压反应来延长出芽酵母的寿命和红孢子虫的寿命。
T21460	Teriparatide acetate hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽	Others	Others
	Teriparatide acetate (Forteo) 是一种 PHT 激动剂，在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide acetate 是一种重组形式的甲状旁腺激素。它是一种有效的合成代谢（即骨骼生长）剂，用于治疗某些形式的骨质疏松症。间歇使用特立帕肽比破骨细胞更能激活成骨细胞，从而导致骨骼整体增加。
T33347	Methylarsonic acid Kyselina methylarsonova,Methylarsinic acid
	Methylarsonic acid is a herbicide and fungicide on growing cotton and rice.
T4543	Telithromycin HMR3647,泰利霉素,Ketek,RU66647	Antibacterial; Antibiotic	Microbiology/Virology
	Telithromycin (HMR3647) 是一种社区获得性肺炎抗生素。
T37179	nTZDpa
	nTZDpa 是一种抗生素，具有抗菌活性。nTZDpa 通过破坏脂质双层有效对抗生长和持续生长的金黄色葡萄球菌。nTZDpa 是一种 PPARG 部分激动剂。
TP2286	Quinupristin (mesylate) (120138-50-3 free base) Quinupristin (mesylate)	Others	Others
	Quinupristin is a streptogramin antibiotic. Streptogramins, a class of antibiotics, is effective in the treatment of vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, which are two of the most rapidly growing strains of mul
T62910	Antibacterial agent 62
	Antibacterial agent 62 是一种新型氧化还原循环抗结核化合物，对生长和营养缺乏的表型耐药非生长细菌表现出显著的杀菌作用。
T68663	GPI-15427
	GPI-15427 is a potent PARP-1 inhibitor capable of crossing the blood-brain barrier, which can significantly increased the antitumor activity of the methylating agent TMZ against malignant melanoma, glioblastoma multiforme, or lymphoma growing at the CNS site. GPI-15427 acts as a potent inhibitor of the enzyme, being capable of inhibiting the activity of purified PARP-1 at nanomolar concentrations. GPI-15427 induced significant sensitization to radiotherapy, representing a promising new treatment...
T71966	PD-128763
	PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. PD-128763 has an IC50 value against the purified enzyme approximately 50X lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enzyme. Exposure of exponentially growing cells to a noncytotoxic concentration (0.5 mM) of PD 128763 for 2 h immediately following X irradiation increased their radiation sensitivity, modifying both the shoulder and the slope of the survival curve. When recovery from sublethal dama...
T66029	3,4-Dehydro-L-proline
	The leguminous shrub,Leucaena leucocephala(Leucaena) is wide‐spread in tropical and subtropical agricultural systems and provides a ready source of protein for livestock. However, the presence of mimosine, a non‐protein, amino acid comprising about 12% of the dry matter in growing tips ofLeucaena, is toxic to animals. Mimosine is degraded rapidly in the rumen to produce 3,4‐dihydroxypyridine (3,4‐DHP) and 2,3‐dihydroxypyridine (2,3‐DHP), both of which remain toxic to animals[1]. 3,4-DHP, as a de...
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

Cat.No: T34406

Synonym: RS-0481,RS0481

Minoxidil sulfate

Cat.No: T8135

Synonym: Minoxidil sulphate,U-58838,米诺地尔硫酸盐

Target: Potassium Channel

2-O-(α-D-Glucopyranosyl)glycerol

Cat.No: T38376

Synonym: 2-alphaGG

Target: Others

Teriparatide acetate

Cat.No: T21460

Synonym: hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽

Target: Others

Methylarsonic acid

Cat.No: T33347

Synonym: Kyselina methylarsonova,Methylarsinic acid

Cat.No: T4543

Synonym: HMR3647,泰利霉素,Ketek,RU66647

Target: Antibacterial, Antibiotic

Cat.No: T37179

Quinupristin (mesylate) (120138-50-3 free base)

Cat.No: TP2286

Synonym: Quinupristin (mesylate)

Target: Others

Antibacterial agent 62

Cat.No: T62910

Cat.No: T68663

Cat.No: T71966

3,4-Dehydro-L-proline

Cat.No: T66029

RWJ-56110 dihydrochloride

Cat.No: T36717

Cat. No.	Product Name	Target	Signaling Pathways
T1310	2-Thiouracil Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶	Thyroid hormone receptor(THR); NO Synthase	Endocrinology/Hormones; Immunology/Inflammation
	2-Thiouracil (Deracil) 是神经型一氧化氮合酶 (nNOS) 的选择性抑制剂(Ki:20 μM)，是一种抗甲状腺化合物，可用作高度特异性的黑色素瘤探测物。
T1113	Imazalil chloramizole,Enilconazole,抑霉唑	Antifungal	Microbiology/Virology
	Imazalil (Enilconazole) 是一种广泛用于农业的杀真菌剂，尤其是柑橘类水果的生长, 也是兽用局部抗真菌剂。
T2994	(E)-Cardamonin Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明	Apoptosis; TRP/TRPV Channel	Apoptosis; Membrane transporter/Ion channel
	(E)-Cardamonin (Alpinetin chalcone) 是一种新型hTRPA1阳离子通道拮抗剂，IC50值为454 nM。
T2818	Methyl Vanillate	Reactive Oxygen Species; Wnt/beta-catenin; Endogenous Metabolite	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells
	Methyl vanillate 是一种枳椇属植物中的提取物，是Wnt/β-catenin 信号通路活化剂，是一种香草酸的甲酯。它具有抗氧化作用。
T1304	Chlortetracycline hydrochloride Isphamycin,Chlortetracycline HCl,7-Chlorotetracycline hydrochloride,盐酸金霉素	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Chlortetracycline hydrochloride (Isphamycin) 是一种特异性钙离子载体抗生素, 抑制氨酰 tRNA 结合到核糖体。
TN4822	Prehelminthosporol	Antifection	Microbiology/Virology
	Prehelminthosporol is a phytotoxin, it may play an important role in pathogenesis by killing or weakening plant cells in advance of the growing hyphae and facilitating nutrient uptake and further growth of the fungus in plant tissue.

天然产物

Cat.No: T1310

Synonym: Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶

Target: Thyroid hormone receptor(THR), NO Synthase

Cat.No: T1113

Synonym: chloramizole,Enilconazole,抑霉唑

Target: Antifungal

Cat.No: T2994

Synonym: Alpinetin chalcone,Cardamomin,小豆蔻明,Cardamonin,(E)-Cardamoni,豆蔻明

Target: Apoptosis, TRP/TRPV Channel

Methyl Vanillate

Cat.No: T2818

Target: Reactive Oxygen Species, Wnt/beta-catenin, Endogenous Metabolite

Chlortetracycline hydrochloride

Cat.No: T1304

Synonym: Isphamycin,Chlortetracycline HCl,7-Chlorotetracycline hydrochloride,盐酸金霉素

Target: ribosome, Antibacterial, Antibiotic

Prehelminthosporol

Cat.No: TN4822

Target: Antifection

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