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Search Results for " gluconeogenesis "

24

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22891	KL001 KL 001,KL-001	Others	Others
	KL001 是一流的隐花色素蛋白 (CRY)稳定剂，可与 CRY1 和 CRY2 特异性相互作用。其中CRY 是一种对蓝光敏感的黄素蛋白，参与调节动植物的昼夜节律。KL001能够防止泛素依赖性 CRY 降解，从而延长了昼夜节律周期，具有控制空腹激素诱导的糖异生的潜力。
T5045	GSK4112 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452	Autophagy	Autophagy
	GSK4112 (SR6452) 是一种 Rev-erbα 激动剂，EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。
T15389L	Glucagon (1-29), bovine, human, porcine hydrochloride 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride	Glucocorticoid Receptor; Glucagon Receptor	Endocrinology/Hormones; GPCR/G Protein
	Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化，促进糖异生。
T64345	4-(Dimethylamino)phenol	Others	Others
	4-(Dimethylamino)phenol enhances extracellular lactate dehydrogenase (LDH) levels without significant effects on gluconeogenesis. Only when the membrane becomes permeable to LDH does 4-(Dimethylamino)phenol reduce ATP content.
T37185	D-(-)-3-Phosphoglyceric acid disodium 3-Phospho-D-glyceric acid disodium	Others	Others
	D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) 是糖酵解、糖原合成以及丝氨酸、甘氨酸、苏氨酸生物合成等过程中的重要中间体,竞争性抑制酵母烯醇化酶 (enolase)。作为中间体它还在植物、真核细胞以及原核细胞许多的生物合成信号通路中发挥许多作用。
T69481	Clanobutin
	Clanobutin inhibits gluconeogenesis and acts as a choleretic and digestion-stimulating agent.
T25572	Ketohypoglycin Methylenecyclopropylpyruvate
	Ketohypoglycin has been utilized to study the inhibition of gluconeogenesis in isolated rat liver cells.
T20028	Janumet Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate
	Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator.
T10786	Charantin	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	Charantin is a steroidal saponin isolated from Momordica charantia. It increases the release of insulin and slowing down gluconeogenesis. Charantin can inhibit GSK-3.
T70141	MDK80908
	MDK80908, also known as PPARalpha/gamma agonist N15, is a dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8.
T36927	Hydrocortisone phosphate
	Hydrocortisone phosphate is the pharmaceutical term for cortisol, which is a steroid hormone, in the glucocorticoid class of hormones, increases blood sugar through gluconeogenesis, to suppress the immune system, and to aid in the metabolism of fat, protein, and carbohydrate.
T35265	YM-440 YM440,YM 440
	YM-440 is a novel hypoglycemic agent, an insulin sensitizer, that may be used for the treatment of type 2 diabetes mellitus by reducing glucose 6-phosphatase activity in obese Zucker rats and inhibiting liver glucose output through gluconeogenesis.
T15389	Glucagon (1-29), bovine, human, porcine 胰高血糖素,Porcine glucagon,Glucagon	Others	Others
	Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation.
T61992	SIK1 activator 1
	SIK1 activator 1可以增强SIK1磷酸化和改善2型糖尿病小鼠的高血糖状态。SIK1 activator 1显示出显著抑制肝脏糖异生的活性。
T37783	2,5-Anhydro-D-mannitol
	2,5-Anhydro-D-mannitol is an antimetabolic fructose analogue that increases food intake in rats at doses of 50-800 mg/kg by inhibiting gluconeogenesis and glycogenolysis in the liver.. It is phosphorylated in the liver, which decreases available ATP and signals eating behavior in rats through a vagal nerve mechanism.
T37521	DL-Glyceraldehyde 3-phosphate 3-Phosphoglyceraldehyde,DL-甘油醛3-磷酸
	DL-Glyceraldehyde-3-phosphate (GADP) is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. In glycolysis, it can be derived from fructose 1,6-bisphosphate by fructose bisphosphate aldolase in a reaction that also produces dihydroxyacetone phosphate (DHAP). Triose phosphate isomerase reversibly converts DHAP to GADP. GADP is processed to 1,3-bisphosphoglycerate by glyceraldehyde phosphate dehydrogenase and NAD+.
T69380	Cinnamic acid, hydrazide
	Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various mechanism of actions including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibiti...
T74941	D-Glyceraldehyde 3-phosphate
	D-Glyceraldehyde 3-phosphate (Triose phosphate) 是一种在生物体内广泛存在的分子，主要作为糖酵解过程和糖异生过程的关键中间体，同时也是卡尔文循环生成糖类的产物。此外，D-Glyceraldehyde 3-phosphate 还涉及色氨酸和硫胺素的生物合成过程。
T75292	Biotin sodium
	Biotin (Vitamin B7) sodium 是一种水溶性维生素 B，是人体五种羧化酶的辅酶，参与脂肪酸、异亮氨酸和缬氨酸的合成，并参与糖异生。Biotin sodium 是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢的必需物质。
T80060	Pyruvate carboxylase	Endogenous Metabolite	Metabolism
	Pyruvate carboxylase是一种催化反应中丙酮酸与HCO3−和MgATP进行依赖性羧化生成草酰乙酸的含生物素酶。它在调控肝脏糖异生、脂肪细胞脂肪酸合成及胰腺β细胞胰岛素分泌方面，对全身能量平衡发挥关键作用。
T83814	8-Bromoguanosine-5'-O-triphosphate sodium 8-bromo GTP
	8-Bromoguanosine-5'-O-triphosphate是一种guanosine 5'-triphosphate (GTP)的衍生物，后者是蛋白质合成和糖异生作用的能量底物。该化合物在31.8 µM的浓度下抑制大肠杆菌的GTPase FtsZ（Ki = 31.8 µM），但在500 µM的浓度下，能促进在无细胞测定中猪脑微管的组装。
T76122	Phosphoglycerate kinase
	Phosphoglycerate kinase(PGK)，即磷酸甘油酸激酶，是一种糖酵解酶，常用于生化研究。Phosphoglycerate kinase 可以催化磷酸基团从1,3-二磷酸甘油酸(1,3-BPG)到ADP 的可逆转移，从而产生 3-磷酸甘油酸(3-PG) 和 ATP。同时也可以参与糖异生，催化相反的反应产生 1,3BPGA 和ADP。Phosphoglycerate kinase 参与了能量代谢、与核酸的相互作用、肿瘤发生进展、细胞死亡和病毒复制等相关过程。
T37120	1,2,3-Triundecanoyl Glycerol
	1,2,3-Triundecanoyl glycerol is a triacylglycerol that contains undecanoic acid at thesn-1,sn-2, andsn-3 positions. Dietary administration of a 7:3 (w/w) mixture of 1,2,3-triundecanoyl glycerol and corn oil prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats compared with dietary administration of corn oil alone.1 1.Pi-Sunyer, F.X., Conway, J.M., Lavau, M., et al.Glucagon, insulin, and gluconeogenesis in fasted o...
T83820	TNP-GTP sodium TNP-Guanosine 5'-triphosphate
	TNP-GTP是一种荧光衍生物，源自蛋白质合成与糖异生的能量底物鸟苷三磷酸(GTP)。其在水中激发波长为410 nm时，发射最大波长为552 nm，而在40%和80%的N,N-二甲基甲酰胺中，其荧光强度增加，发射波长分别向544 nm和532 nm移动，这是因为N,N-二甲基甲酰胺的极性比水小。TNP-GTP是谷氨酸脱氢酶的抑制剂(Ki = 2.7 μM)。当与谷氨酸脱氢酶结合时，TNP-GTP的荧光强度增加，且发射波长从552 nm变为545 nm，此效果可以通过加入GTP来阻断。TNP-GTP还是嘌呤P2X2和P2X2/3受体的拮抗剂(IC50s分别为0.4和1.2 nM)。它还选择性抑制大鼠可溶性鸟苷酸环化酶(sGC; Ki = 11 nM)高于牛肝谷氨酸脱氢酶(GDH; Ki = 2.7 µM)以及钙调素依赖的B. pertussis腺苷酸环化酶(AC)毒素(Kis在存在锰或镁时分别为20和320 µM)。

化合物

Cat.No: T22891

Synonym: KL 001,KL-001

Target: Others

Cat.No: T5045

Synonym: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452

Target: Autophagy

Glucagon (1-29), bovine, human, porcine hydrochloride

Cat.No: T15389L

Synonym: 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride

Target: Glucocorticoid Receptor, Glucagon Receptor

4-(Dimethylamino)phenol

Cat.No: T64345

Target: Others

D-(-)-3-Phosphoglyceric acid disodium

Cat.No: T37185

Synonym: 3-Phospho-D-glyceric acid disodium

Target: Others

Cat.No: T69481

Cat.No: T25572

Synonym: Methylenecyclopropylpyruvate

Cat.No: T20028

Synonym: Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate

Cat.No: T10786

Target: GSK-3

Cat.No: T70141

Hydrocortisone phosphate

Cat.No: T36927

Cat.No: T35265

Synonym: YM440,YM 440

Glucagon (1-29), bovine, human, porcine

Cat.No: T15389

Synonym: 胰高血糖素,Porcine glucagon,Glucagon

Target: Others

SIK1 activator 1

Cat.No: T61992

2,5-Anhydro-D-mannitol

Cat.No: T37783

DL-Glyceraldehyde 3-phosphate

Cat.No: T37521

Synonym: 3-Phosphoglyceraldehyde,DL-甘油醛3-磷酸

Cinnamic acid, hydrazide

Cat.No: T69380

D-Glyceraldehyde 3-phosphate

Cat.No: T74941

Cat.No: T75292

Pyruvate carboxylase

Cat.No: T80060

Target: Endogenous Metabolite

8-Bromoguanosine-5'-O-triphosphate sodium

Cat.No: T83814

Synonym: 8-bromo GTP

Phosphoglycerate kinase

Cat.No: T76122

1,2,3-Triundecanoyl Glycerol

Cat.No: T37120

Cat.No: T83820

Synonym: TNP-Guanosine 5'-triphosphate

Cat. No.	Product Name	Target	Signaling Pathways
TN7038	Regaloside H	Others	Others
	Regaloside H 是一种糖异生抑制剂，是一种苯丙酸甘油糖苷。它能够抑制大鼠肝癌细胞中葡萄糖的产生。
T1116	Biotin Vitamin B7,生物素,D-Biotin,Vitamin H,D-生物素（维生素H）
	Biotin (Vitamin H) 是一种水溶性B族维生素，是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢所必需的。
T1614	Hydrocortisone 氢化可的松,Cortisol	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Hydrocortisone (Cortisol) 是一种糖皮质激素，由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体，可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄，并抑制免疫和炎症反应。
T37984	D-Fructose-1,6-bisphosphate sodium salt hydrate	Others	Others
	D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体，包括糖酵解和糖异生。在糖酵解过程中，它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中，D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源，这一途径已成为癌症化疗的主要靶点。
T5248	(R)-3-Hydroxybutanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	(R)-3-Hydroxybutanoic acid 是一种代谢物，在 3-羟基丁酸脱氢酶催化下由乙酸乙酯转化而成。它可以作为营养来源和抗生素、维生素和信息素的前体。
T3976	Cytosporone B Csn-B,Dothiorelone G	Others	Others
	Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。
TN4997	Serpentine	IGF-1R	Tyrosine Kinase/Adaptors
	Serpentine 是一种玫瑰花根中的生物碱，可用作胰岛素增敏剂，以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化，从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达，从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素（HFD/STZ）诱导的糖尿病小鼠中，Serpentine 显著延长了胰岛素的降血糖时间，显著降低了外源性胰岛素的使用，抑制了内源性胰岛素的分泌。
T73074	Phanginin A
	Phanginin A 是有效的口服活性SIK1激活剂，通过抑制糖异生、增加p-SIK1表达及降低p-CREB表达，达到降低血糖水平、改善葡萄糖耐量和血脂异常的效果，显示出其在2型糖尿病研究中的潜力。

天然产物

Cat.No: TN7038

Target: Others

Cat.No: T1116

Synonym: Vitamin B7,生物素,D-Biotin,Vitamin H,D-生物素（维生素H）

Cat.No: T1614

Synonym: 氢化可的松,Cortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

D-Fructose-1,6-bisphosphate sodium salt hydrate

Cat.No: T37984

Target: Others

(R)-3-Hydroxybutanoic acid

Cat.No: T5248

Target: Others, Endogenous Metabolite

Cat.No: T3976

Synonym: Csn-B,Dothiorelone G

Target: Others

Cat.No: TN4997

Target: IGF-1R

Cat.No: T73074

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