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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2678 |
LB42708
|
Transferase | Metabolism |
LB42708 是一种口服有活力的特异性法尼基转移酶抑制剂。它对H-Ras、N-Ras 和K-Ras4B 的法尼基化均有抑制作用,其IC50分别为 0.8 nM、1.2 nM 和 2.0 nM。 | |||
T38050 |
CP-609754
|
Transferase | Metabolism |
CP-609754 是高效的、可逆的法尼基转移酶抑制剂,对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。 | |||
T17102 |
Tipifarnib (S enantiomer)
Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer |
Transferase | Metabolism |
Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体,它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂,IC50=0.6 nM。 | |||
T27773L |
L-739750 2HCl
L-739750 2HCl(160141-08-2 Free base) |
Transferase | Metabolism |
L-739750 2HCl 是一种有效的拟肽法尼基转移酶的抑制剂,是一种新型假肽模拟物,具有潜在的抗癌活性。 | |||
T2700 |
FTI-277 hydrochloride
FTI 277 HCl |
Apoptosis; Transferase; Ras | Apoptosis; GPCR/G Protein; MAPK; Metabolism |
FTI-277 hydrochloride (FTI 277 HCl) 是一种法尼基转移酶FTase 抑制剂,高效 Ras CAAX 肽模拟物,可抑制H-Ras 和K-Ras 信号转导,还可抑制hepatitis delta virus 感染。 | |||
T10512 |
Prenyl-IN-1
|
Transferase | Metabolism |
Prenyl-IN-1 是一种具有有效性和选择性的 prenylation 抑制剂,对香叶烯基转移酶 (geranylgeranyltransferase) 或法尼基转移酶 (farnesyltransferase) 具有抑制作用。Prenyl-IN-1 在帕金森模型中显示出抗氧化应激作用。 | |||
T24273 |
Kurasoin B
Kurasoin-B |
||
Kurasoin B is an inhibitor of protein farnesyltransferase. | |||
T15770 |
(Rac)-CP-609754
LNK754 |
Influenza Virus | Microbiology/Virology |
LNK754 is a farnesyltransferase inhibitor. It is used for the treatment of cancer and Alzheimer's disease. | |||
T40331 |
Ftase inhibitor III
|
||
Ftase Inhibitor III, derived from a phenotypic screen, functions as an anion-dependent inhibitor of Farnesyltransferase. | |||
T11331L |
FTI 276
|
Others | Others |
FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human). | |||
T24351 |
L 731735
L-731,735,L731735,L-731735,L731,735,L 731,735 |
||
L 731735 is a farnesyltransferase inhibitor. | |||
T27773 |
L-739750
|
||
L-739,750 is an inhibitor (FTI) of peptidomimetic farnesyltransferase. | |||
T71375 | FTI-2600 | ||
FTI-2600 is a farnesyltransferase inhibitor. | |||
T69710 | LB42908 | ||
LB42908 is a highly potent Ras farnesyltransferase inhibitor(IC(50)=0.9 nM against H-Ras and 2.4 nM against K-Ras) with potential anticancer activity. | |||
T24350 |
L 731734
L-731,734,L 731,734,L731734,L731,734,L-731734 |
||
L 731734 is a farnesyltransferase inhibitor. | |||
T70372 |
FTI-249
|
||
FTI-249 is a Farnesyltransferase inhibitor, which potently inhibited FTase (IC50 = 100–200 nM). | |||
T25939 | Pepticinnamin E | ||
Pepticinnamin E is a naturally occurring bisubstrate farnesyltransferase inhibitor. | |||
T70554 |
Chaetomellic acid A
|
||
Chaetomellic acid A is a potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=55nM) but is inactive in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=92µM and 34µM respectively). | |||
T68227 |
BMS-214662 HCl
|
||
BMS-214662 is a Farnesyltransferase inhibitor , is also a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnesylation of number of proteins involved in signal transduction, which may result in the inhibition of Ras function and apoptosis in susceptible tumor cells. This agent may reverse the malignant phenotype of H-Ras-transformed cells and has been shown to be active against tumor cell... | |||
T70405 |
L-744832
|
||
L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity. | |||
T68923 |
FTI-2628
|
||
FTI-2628 is a novel inhibitor of protein farnesyltransferase (FT), inhibiting the growth of P. falciparum in red blood cells and suppressing parasitemia. | |||
T15353 |
FTI-2153
|
Others | Others |
FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM). FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. | |||
T69994 |
BIM-46050
|
||
BIM-46050 is a potent and specific inhibitor of human farnesyltransferase. BIM-46050 is free acidic form of BIM-46068. The IC50 values for in vitro inhibition of human brain FTase indicate that BIM-46050 and the ester form BIM-46068 are potent inhibitors of farnesyltransferase. Their potencies are in the nanomolar range and compare favorably with the compounds B581, FTI-277 and L745,631. B581 is an analog of the tetrapeptide Cys-Val-Phe-Met obtained by replacement of the amino-terminal amide bon... | |||
T64101 | FTI-2153 TFA | ||
FTI-2153 TFA 是一种高选择性的、有效的法尼基转移酶 farnesyltransferase (FTase) 抑制剂 (IC50: 1.4 nM)。FTI-2153 TFA 可有效抑制 H-Ras 蛋白的加工修饰 (IC50: 10 nM),对其抑制活性是对 Rap1A 蛋白加工的 3000 多倍。 | |||
T69993 |
BIM-46068
|
||
BIM-46068 is a potent and specific inhibitor of human farnesyltransferase. In regard to a panel of cell lines, using the Compare analysis to determine the Pearson coefficient correlation, the anti-proliferative spectrum of BIM-46068 has been shown to be distinct from the profile of typical chemotherapeutic agents. | |||
T62675 |
FTI-277
|
||
FTI-277 是一种法尼基转移酶 FTase 抑制剂,也是一种高效 Ras CAAX 肽模拟物。FTI-277 对 H-Ras 和 K-Ras 信号转导具有抑制作用,能够抑制 hepatitis delta virus (HDV) 感染。 | |||
T70287 |
BMS-186511
|
||
BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a clos... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16011 |
Manumycin A
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling. Manumycin A acts as a selective, competitive inhibitor of |