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Search Results for " eliciting "

17

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8485	THIQ	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂，对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。
T0824	4-Nonylphenol polyethoxylate Nonoxynol,Nonoxinol-9,壬苯醇醚	COX	Immunology/Inflammation; Neuroscience
	4-Nonylphenol polyethoxylate (Nonoxinol-9) 是一种表面活性剂，普遍用作避孕药中的杀精剂。
T37617	Leukotriene B3
	LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.
T40511	TET 830 modified/T-helper epitope from tetanus toxoid
	TET 830 modified/T-helper epitope from tetanus toxoid is a T-cell stimulating peptide derived from tetanus toxoid. It acts as a helper peptide in vaccinations, eliciting T-cell responses.
T15502	HQ-415	Others	Others
	HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting an EC50 for HQ-415 is 15 μM.
T78000	OVA Peptide (323-339)
	OVA Peptide (323-339) 是卵清蛋白(OVA)的T和B细胞表位，对BALB/c小鼠的瞬时超敏反应生成与发展至关重要。
T78809	NDNA3	HSP	Cytoskeletal Signaling; Metabolism
	NDNA3 (compound 14)，一种选择性Hsp90α抑制剂，IC50为0.51 μM。该永久带电类似物具低膜渗透性，并对Ovcar-8细胞（IC50为12.66 μM）和MCF-10A细胞（IC50为11.72 μM）展现较低细胞毒性。NDNA3能够防止hERG通道成熟受损，不引发热休克反应或导致对Hsp90α依赖的客户蛋白降解。
T37668	CAY10448 CAY10448
	Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Capsaicin signals are transduced by a heat-activated ion channel, the vanilloid receptor 1 (VR1), or transient receptor potential vanilloid 1 (TRPV1). CAY10448 is an iodinated nonivamide, a potent capsaicin receptor antagonist with an IC50 value of approximately 10 nM.
T14035	3M-011	TLR	Immunology/Inflammation
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].
T81502	Pezadeftide	Antibiotic	Microbiology/Virology
	Pezadeftide为一种抗真菌肽，能够穿透真菌细胞并迅速诱发线粒体反应，进而引起线粒体膜超极化。
T36238	6α-Prostaglandin I1 6α-Prostaglandin I1
	6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI...
T81444	PL-3994
	PL-3994作为NPR-A的激动剂，展现了对中性肽酶的耐药特性，具有支气管扩张效应。对预收缩豚鼠气管，PL-3994表现出浓度依赖性的弛豫作用，其IC50值为42.7 nM。
T78006	Prolactin Releasing Peptide (1-31), human acetate
	ProlactinReleasing Peptide (1-31), human (acetate) 是一款针对 GPR10 的高亲和力配体，并具备诱导催乳素释放的功能。该肽段与人类和大鼠的 GPR10 结合力极强，Ki 值分别为 1.03 nM 和 0.33 nM，适用于针对下丘脑-垂体轴进行的生物医学研究。
T82280	Gly-Gly-Arg
	Gly-Gly-Arg为一种三肽，其功能为孵化卵中的“泵信息素”。该化合物能诱导腹足泵活动，具有10 nM的阈值浓度，并展现出58.3%的最大百分比响应。在潮下甲壳类动物中，Gly-Gly-Arg作为信息素发挥作用，控制幼虫的释放。
T78808	NDNA4	HSP	Cytoskeletal Signaling; Metabolism
	NDNA4（compound 17）作为Hsp90α选择性抑制剂，具有0.34 μM的IC50值。作为永久带电的类似物，该化合物显示出低膜渗透性，并在Ovcar-8和MCF-10A细胞中表现出较低的细胞毒性（IC50>100 μM）。NDNA4能够保护hERG通道免遭破坏，同时不触发热休克反应或引起对Hsp90α依赖的客户蛋白进行降解。
T83406	2,3-Diphospho-D-glyceric acid pentasodium salt 2,3-DPG pentasodium salt
	2,3-Diphospho-D-glyceric acid pentasodium salt 是一种聚磷化合物，具有明显的阴离子性质。它在红细胞的凹中心起作用，通过结合血红蛋白降低氧亲和力。作为血管钙化 (VC) 的内源性选择性抑制剂，2,3-Diphospho-D-glyceric acid 能显著推迟结晶钙蛋白颗粒 (CPP) 的生成，并在小鼠血管平滑肌细胞系 (MOVAS) 中抑制钙化作用，同时不引起细胞毒性。
T35598	Neuromedin U-25 (human) (trifluoroacetate salt)
	Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery ...

化合物

Cat.No: T8485

Target: Melanocortin Receptor

4-Nonylphenol polyethoxylate

Cat.No: T0824

Synonym: Nonoxynol,Nonoxinol-9,壬苯醇醚

Target: COX

Cat.No: T37617

TET 830 modified/T-helper epitope from tetanus toxoid

Cat.No: T40511

Cat.No: T15502

Target: Others

OVA Peptide (323-339)

Cat.No: T78000

Cat.No: T78809

Target: HSP

Cat.No: T37668

Synonym: CAY10448

Cat.No: T14035

Target: TLR

Cat.No: T81502

Target: Antibiotic

6α-Prostaglandin I1

Cat.No: T36238

Synonym: 6α-Prostaglandin I1

Cat.No: T81444

Prolactin Releasing Peptide (1-31), human acetate

Cat.No: T78006

Cat.No: T82280

Cat.No: T78808

Target: HSP

2,3-Diphospho-D-glyceric acid pentasodium salt

Cat.No: T83406

Synonym: 2,3-DPG pentasodium salt

Neuromedin U-25 (human) (trifluoroacetate salt)

Cat.No: T35598

Cat. No.	Product Name	Target	Signaling Pathways
TN2088	Platycodin D2 桔梗皂苷D2	IL Receptor; HBV	Immunology/Inflammation; Microbiology/Virology
	Platycodin D2 是分离自桔梗的皂苷类物质，显示除抗癌活性。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。

天然产物

Cat.No: TN2088

Synonym: 桔梗皂苷D2

Target: IL Receptor, HBV

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

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