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34

抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8599	Betazole dihydrochloride 盐酸倍他唑,Betazole hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betazole dihydrochloride (Betazole hydrochloride) 是吡唑类组胺，是一种口服活性 H2受体激动剂，能诱导胃酸分泌，导致胆总管压力立即显著升高。它作为一种诊断剂，用于研究胃酸分泌能力。
T72078	Xanthine oxidoreductase-IN-4	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-4 是一种具有有口服活性黄嘌呤氧化还原酶 (XOR) 抑制剂，对 XOR 具有抑制作用，IC50 值为 29.3 nM。Xanthine oxidoreductase-IN-4 可用于研究高尿酸血症。
T14175	Aldose reductase-IN-1 AT-001,Caficrestat	Others; Reductase	Endocrinology/Hormones; Metabolism; Others
	Aldose reductase-IN-1 (AT-001)是醛糖还原酶的高效抑制剂, IC50=为28.9 pM。
T72166	Xanthine oxidoreductase-IN-5	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-5 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂（IC50 ： 55 nM）。Xanthine oxidoreductase-IN-5 可用于急性高尿酸血症的研究。
TP1604L	Thioredoxin reductase peptide acetate Thioredoxin reductase peptide acetate(950890-23-0 free base)	Others	Others
	Thioredoxin reductase peptide acetate(950890-23-0 free base) 对应于硫氧还蛋白还原酶 (TrxR) 中的 53–67 位残基，用于硫氧还蛋白还原酶研究。哺乳动物硫氧还蛋白还原酶 (TR) 催化硫氧还蛋白 (Trx) 的氧化还原活性二硫键的还原，并且在结构和谷胱甘肽还原酶的作用机制，除了 C 末端的 16 个氨基酸延伸部分含有一个罕见的连位硒硫键。
T72165	Xanthine oxidoreductase-IN-3	Xanthine Oxidase	Metabolism
	Xanthine oxidoreductase-IN-3 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂（IC50 ： 26.3 nM）。Xanthine oxidoreductase-IN-3 可用急性高尿酸血症的研究。
TP1604	Thioredoxin reductase peptide
	Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfide bond of thioredoxin (Trx) and is
T79520	HMG-CoA Reductase-IN-1
	HMG-CoA Reductase-IN-1是一种HMG-CoA还原酶抑制剂，显示出高HMGR抑制活性及OATP1B1亲和力，具有pIC50值8.54和pKm值1.98。该化合物适用于高胆固醇血症的研究。
T79981	Nitric oxide production-IN-1	NO Synthase	Immunology/Inflammation
	Nitric oxide production-IN-1（Compound 1）是从Tupistra chinensis中提取的一种NO产生抑制剂，能够抑制脂多糖诱导的大鼠腹腔巨噬细胞NO产量。
T80057	Cytochrome P450 reductase
	Cytochrome P450reductase，一种NADPH-细胞色素还原酶，发挥作用于促进芳香酶构象，以最适合底物结合。
T60890	Xanthine oxidoreductase-IN-1
	Xanthine oxidoreductase-IN-1 是黄嘌呤氧化还原酶（XOR）的抑制剂，IC50值为7.0 nM。
T31448	Diethylamine dinitric oxide adduct DEANO
	Diethylamine dinitric oxide adduct is a nitric oxide generator.
T64624	RuPhos Pd G1 Methyl t-Butyl Ether Adduct
	Chloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) 2-methoxy-2-methylpropane complex 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64624。
T62951	Aldose reductase-IN-2
	Aldose reductase-IN-2 (Compound 5f) 是一种醛糖还原酶 (AR) 的有效抑制剂，具有抗氧化作用。Aldose reductase-IN-2 是一种很有前途的抗糖尿病并发症药物。
T61555	Aldose reductase-IN-6
	Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR), possessing an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells [1].
T61957	Aldose reductase-IN-3
	Aldose reductase-IN-3 (Compound 5) 是有效的、中等选择性的醛糖还原酶 (AR) 抑制剂（IC50= 3.99 μM）。醛糖还原酶是参与各种炎症性疾病 (包括败血症) 的分子靶标。Aldose reductase-IN-3在脓毒症中具有研究的潜力。
T78342	Glutathione reductase EC 1.6.4.2
	Glutathione reductase (EC 1.6.4.2) 是维持还原型谷胱甘肽供应的还原酶。
T10636	5α-reductase-IN-1	Others	Others
	5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in combination with minoxidil, a well-known treatment for hair loss.
T35788	Orlistat Degradation Product (sodium salt)
	Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat . It is formed via hydrolytic and thermal degradation as well as digestion by human carboxyl ester lipase.
T60897	Aldose reductase-IN-5
	Aldose reductase-IN-5 是一种醛糖还原酶（ALR2）抑制剂，可增强抑制性兴奋性和抗氧化能力的组合，从而延缓糖尿病并发症的进程。
T60601	Aldose reductase-IN-4
	Aldose reductase-IN-4 (comund IIc) 是一种醛糖还原酶的抑制剂，其对ALR1和ALR2的IC50值分别为 11.70 μM 和 0.98 μM。
TP1375	Thioredoxin reductase peptide TFA
	Thioredoxin reductase peptide TFA corresponds to residues 53-67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research..
T30743	Carbon dioxide reduction factor Methanofuran,Cdr factor
	Carbon dioxide reduction factor is a coenzyme of methanogenesis from carbon dioxide.
T61162	Xanthine oxidoreductase-IN-2
	Xanthine oxidoreductase-IN-2 (Compound IVa) is a potent inhibitor of xanthine oxidoreductase (XOR) with an IC50 value of 7.2 nM. Notably, Xanthine oxidoreductase-IN-2 demonstrates hypouricemic effects in mice, as evidenced by [1].
T83318	4-Hydrazino-7-nitro-benzofurazan hydrazine adduct NBD-H
	4-Hydrazino-7-nitro-benzofurazan hydrazine adduct 是一种荧光试剂，主要用于蛋白质标记。
T16376	Odevixibat A4250	Others	Others
	Odevixibat (A4250) (A4250) 是一种有效的选择性回肠胆汁酸转运蛋白 (IBAT) 抑制剂。Odevixibat (A4250) 可减轻小鼠模型中的胆汁淤积性肝和胆管损伤。Odevixibat (A4250)可用于原发性胆汁性肝硬化的研究。
T24769	Scaff10-8 Scaff 10 8,Scaff-10-8
	Scaff10-8 is an inhibitor of AKAP-Lbc-RhoA interaction that acts by promoting the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
T37845	Taurocholic Acid 3-sulfate (sodium salt)
	Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-o...
T35728	Hydrochlorothiazide Impurity C
	Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. [1] Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.[2][3][4]
T78632	Z-LLY-FMK Calpain Inhibitor IV	Proteasome	Proteases/Proteasome; Ubiquitination
	Z-LLY-FMK (Calpain Inhibitor IV) 为一种钙蛋白酶抑制剂，涉及调控多个细胞系统的凋亡过程。该化合物能够抑制胆总管结扎所引起的肠细胞凋亡(apoptosis)。
T72005	Betazole Ametazole
	Betazole (Ametazole) 为一种吡唑类组胺，具有口服活性，作为H2受体激动剂发挥作用。该化合物能诱导胃酸分泌并立即显著提高胆总管压力。Betazole 作为一种称为histalog的诊断剂，应用于评估胃酸分泌功能。
TMIH-0257	Glycoursodeoxycholic Acid-d4
	Glycoursodeoxycholic Acid-d4 是 Glycoursodeoxycholic Acid 的氘代化合物。Glycoursodeoxycholic Acid 的 CAS 号为 64480-66-6。Glycoursodeoxycholic acid 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物，是熊去氧胆酸的代谢物。
T69686	BMS-986318
	BMS-986318 是一种有效的非胆汁酸FXR 激动剂，在FXRGal4 和 SRC-1 募集试验中的EC50分别为 53 和 350 nM。 BMS-986318 具有合适的 ADME 特性，并在肝胆汁淤积和纤维化的小鼠胆管结扎模型中具有效果。BMS-986318 可用于非酒精性脂肪性肝炎 (NASH)的研究。
T35494	(±)11(12)-EET
	(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in t...

化合物

Betazole dihydrochloride

Cat.No: T8599

Synonym: 盐酸倍他唑,Betazole hydrochloride

Target: Histamine Receptor

Xanthine oxidoreductase-IN-4

Cat.No: T72078

Target: Xanthine Oxidase

Aldose reductase-IN-1

Cat.No: T14175

Synonym: AT-001,Caficrestat

Target: Others, Reductase

Xanthine oxidoreductase-IN-5

Cat.No: T72166

Target: Xanthine Oxidase

Thioredoxin reductase peptide acetate

Cat.No: TP1604L

Synonym: Thioredoxin reductase peptide acetate(950890-23-0 free base)

Target: Others

Xanthine oxidoreductase-IN-3

Cat.No: T72165

Target: Xanthine Oxidase

Thioredoxin reductase peptide

Cat.No: TP1604

HMG-CoA Reductase-IN-1

Cat.No: T79520

Nitric oxide production-IN-1

Cat.No: T79981

Target: NO Synthase

Cytochrome P450 reductase

Cat.No: T80057

Xanthine oxidoreductase-IN-1

Cat.No: T60890

Diethylamine dinitric oxide adduct

Cat.No: T31448

Synonym: DEANO

RuPhos Pd G1 Methyl t-Butyl Ether Adduct

Cat.No: T64624

Aldose reductase-IN-2

Cat.No: T62951

Aldose reductase-IN-6

Cat.No: T61555

Aldose reductase-IN-3

Cat.No: T61957

Glutathione reductase

Cat.No: T78342

Synonym: EC 1.6.4.2

5α-reductase-IN-1

Cat.No: T10636

Target: Others

Orlistat Degradation Product (sodium salt)

Cat.No: T35788

Aldose reductase-IN-5

Cat.No: T60897

Aldose reductase-IN-4

Cat.No: T60601

Thioredoxin reductase peptide TFA

Cat.No: TP1375

Carbon dioxide reduction factor

Cat.No: T30743

Synonym: Methanofuran,Cdr factor

Xanthine oxidoreductase-IN-2

Cat.No: T61162

4-Hydrazino-7-nitro-benzofurazan hydrazine adduct

Cat.No: T83318

Synonym: NBD-H

Cat.No: T16376

Synonym: A4250

Target: Others

Cat.No: T24769

Synonym: Scaff 10 8,Scaff-10-8

Taurocholic Acid 3-sulfate (sodium salt)

Cat.No: T37845

Hydrochlorothiazide Impurity C

Cat.No: T35728

Cat.No: T78632

Synonym: Calpain Inhibitor IV

Target: Proteasome

Cat.No: T72005

Synonym: Ametazole

Glycoursodeoxycholic Acid-d4

Cat.No: TMIH-0257

Cat.No: T69686

Cat.No: T35494

Cat. No.	Product Name	Target	Signaling Pathways
T5234	Glycoursodeoxycholic acid Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA	Others; Endogenous Metabolite	Metabolism; Others
	Glycoursodeoxycholic acid (Ursodeoxycholylglycine) 是一种酰基甘氨酸和胆汁酸-甘氨酸缀合物，是熊去氧胆酸的代谢物。
T7711	Uridine triphosphate 尿苷5'-三磷酸酯,UTP,Uridine 5'-triphosphate,三磷酸尿苷	Others; Endogenous Metabolite	Metabolism; Others
	Uridine triphosphate (Uridine 5'-triphosphate) 是一种核苷酸，调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。
TCA2511	11Beta-hydroxyprogesterone	Sodium Channel	Membrane transporter/Ion channel
	The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.

天然产物

Glycoursodeoxycholic acid

Cat.No: T5234

Synonym: Ursodeoxycholylglycine,甘氨熊胆酸,GUDCA

Target: Others, Endogenous Metabolite

Uridine triphosphate

Cat.No: T7711

Synonym: 尿苷5'-三磷酸酯,UTP,Uridine 5'-triphosphate,三磷酸尿苷

Target: Others, Endogenous Metabolite

11Beta-hydroxyprogesterone

Cat.No: TCA2511

Target: Sodium Channel

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