搜索结果

Search Results for " dermal fibroblasts "

抑制剂 & 化合物

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T1850	Balicatib AAE581,巴利卡替	Cysteine Protease	Proteases/Proteasome
	Balicatib (AAE581) 是组织蛋白酶K 抑制剂，其对组织蛋白酶K 的抑制作用是组织蛋白酶B、L 和S 的抑制性的10到100倍。
T3636	(E)-SIS3 SIS3,SIS3 盐酸盐,SIS3 HCl	TGF-beta/Smad	Stem Cells
	(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂，能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。
T80654	3,3′-Bisdemethylpinoresinol	MMP	Proteases/Proteasome
	3,3′-Bisdemethylpinoresinol，一种木质素类的天然产物，具有抑制UVA照射下人真皮成纤维细胞中MMP-1的活性。该化合物可从Morinda citrifolia种子中分离提取。
T70826	PF-03671148
	PF-03671148 is a potent ALK inhibitor. PF-03671148 inhibits the expression of fibrotic genes and protein markers both in vitro in human fibroblasts and in vivo in a rat wound repair model. Wound healing is not inhibited by the topical application of the ALK5 inhibitor to the wound. PF-03671148 may have potential utility for the prevention of dermal scarring.
T78764	Anticancer agent 136	Apoptosis	Apoptosis
	Anticanceragent 136 (compound 22)，一种GDM C17-三唑类似物，对HDF表现出3.38 μM的IC50，与Hsp90有3.86 μM的Kd。本化合物功能为细胞凋亡诱导剂。
T36929	Pal-KTTKS (acetate)
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...
T35982	Capsorubin	Apoptosis; Antiviral	Apoptosis; Immunology/Inflammation
	Capsorubin 是一种类胡萝卜素，具有多种生物活性。Capsorubin 在 167 μM 浓度下，对 2,2′-偶氮(2,4-二甲基戊腈)(AMVN) 诱导的脂质过氧化有抑制作用。capsorubin (1 μM) 可降低 uvb 诱导的人真皮成纤维细胞 DNA 链断裂和凋亡的形成。它还能抑制 Raji 细胞中由12-Carnosine 13-acetate 诱导的 eb 病毒早期抗原 (EBV-EA) 激活。
T83744	Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17是一种环状肽，属于tigerinin-RC1和tigerinin-RC2的衍生物，这两种化合物是在螃蟹吃蛙（F. cancrivora）皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时，Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖，并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外，Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中，局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。

化合物

Balicatib

Cat.No: T1850

Synonym: AAE581,巴利卡替

Target: Cysteine Protease

(E)-SIS3

Cat.No: T3636

Synonym: SIS3,SIS3 盐酸盐,SIS3 HCl

Target: TGF-beta/Smad

3,3′-Bisdemethylpinoresinol

Target: Apoptosis

Target: Apoptosis, Antiviral

Tiger17 TFA

Cat.No: T83744

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN7117	regaloside I	Others	Others
	Regaloside I 是百合中的单体成分,可能是保护人类皮肤成纤维细胞免受 UVA 诱导的形态变化的主要成分。
T5120	Rhamnose 6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose	Calcium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	alpha-L-Rhamnose (6-Deoxy-L-mannose) 是存在植物和细菌中的一种单糖。Rhamnose- 免疫原连接物能被用于免疫疗法。Rhamnose 能通过胞外途径穿过上皮细胞，能够作为肠吸收的标志。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...