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Search Results for " demethylation "

25

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19721	Epoxiconazole BAS-480F,BAS 480F,EC 406 850 2,氟环唑,BAS480F,EC-406-850-2	Antifungal	Microbiology/Virology
	Epoxiconazole (BAS-480F) 是一种 14-α 去甲基化酶抑制剂，抑制麦角甾醇的合成和真菌细胞壁的形成。它是一种杀菌剂，对耐多菌灵和耐苯甲酰胺的菌株均表现出强大的抑制作用，可用于控制多种农作物病害。
T2199	Myclobutanil Systhane,腈菌唑	Antifungal	Microbiology/Virology
	Myclobutanil (Systhane) 是康唑类抗真菌剂，可用作农药。
T7867	Flutriafol	NMDAR; Antifungal	Microbiology/Virology; Neuroscience
	Flutriafol 是一种三唑类广谱杀菌试剂。
T26829	Bitertanol KWG-0599,联苯三唑醇,KWG0599,Baycor,Biloxazol,KWG 0599,Sibutol	Antifungal	Microbiology/Virology
	Bitertanol (KWG 0599) 是一种三唑类杀菌剂。 Bitertanol 抑制去甲基化，破坏膜功能，并阻止甾醇合成。
T27918	LY 43578 LY-43578,LY43578	P450; Aromatase	Endocrinology/Hormones; Metabolism
	LY 43578 是一种具有口服活性的芳香酶 (aromatase) 抑制剂。LY 43578 对大鼠肝微粒体 P-450依赖的 p-nitroanisole 的 O -去甲基化和 ethylmorphine 的 N -去甲基化有抑制作用，IC50 分别为 0.3 和 5 μΜ。LY 43578 可用于研究神经系统疾病和心血管疾病。
T38173	Propargylcholine Propargylcholine (bromide)	Antibacterial	Microbiology/Virology
	Propargylcholine (Propargylcholine (bromide)) 是一种炔烃修饰的胆碱类似物，在铜绿假单胞菌中 Dgc 酶催化的二甲基甘氨酸去甲基化水平上抑制胆碱分解代谢。
T11469	GSK-3484862	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3484862 是有效的 DNA 甲基转移酶 Dnmt1的非共价抑制剂。GSK-3484862 通过诱导 DNA 低甲基化起抗癌作用。GSK-3484862 介导小鼠胚胎干细胞的整体去甲基化。
T4498	Stiripentol 斯利潘托,BCX2600,Diacomit	P450	Metabolism
	Stiripentol (BCX2600) 是抗惊厥剂，对 CYP3A4 (非竞争性) 及 CYP2C19 (竞争性地) 介导的 CLB 向 N-desmethylclobazam (NCLB) 的 N-去甲基化具有抑制作用。
T6686	Sulconazole mononitrate Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Sulconazole mononitrate (Exelderm) 是一种咪唑类广谱杀菌剂。它可研究皮肤真菌病，花斑糠疹病，皮肤念珠菌病。
T5966	Hexaconazole 己唑醇,(-)-Hexaconazol	Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Hexaconazole ((-)-Hexaconazol) 是一种广谱三唑类杀菌剂，通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成，从而导致真菌细胞膜的破坏和细胞死亡。
T35363	HM-cytosine 5hmC,5-Hydroxymethylcytosine,5-羟甲基胞嘧啶	Others	Others
	HM-cytosine (5hmC) (5hmC) 是哺乳动物基因组 DNA 中天然存在的成分，被认为是 DNA 的第六个碱基。HM-cytosine 是活性 DNA 去甲基化的中间代谢物。HM-cytosine 是已知会影响哺乳动物全局基因表达的表观遗传标记。
T3934	Isavuconazonium sulfate	Antifungal	Microbiology/Virology
	Isavuconazonium sulfate 是一种口服活性抗真菌药，是活性三唑类抗真菌药物 Isavuconazole 的前药，可用于侵袭性曲霉菌病和毛霉菌病。
T1290	Oxiconazole nitrate 硝酸奥昔康唑,Ro 13-8996	Others; Antibiotic; Antifection; Antifungal	Microbiology/Virology; Others
	Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物，抑制T. tonsurans 和T.rubrum 的生长，MIC90值分别为 0.25 和 0.5 μg/mL。
T71926	Melperone hydrochloride
	Melperone hydrochloride is a butyrophenone neuroleptic and an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.
T69167	Buthiobate
	Buthiobate is a fungicide which inhibits lanosterol 14 alpha-demethylation catalyzed by a cytochrome P-450.
T26649	Arasertaconazole
	Arasertaconazole, a sterol-14-alpha demethylation inhibitor, is used potentially for the treatment of vulvovaginal candcanidiasis.
T72388	CBB1007 hydrochloride
	CBB1007 hydrochloride，一种可逆的、选择性的高效组蛋白去甲基化酶LSD1的底物竞争性抑制剂，其对hLSD1的IC50值为5.27 uM。
T29453	5-Formylcytosine
	5-formylcytosine (5FC) is a rare base found in mammalian DNA. It participates in active DNA demethylation, changes DNA double helix structure, and reduces the transcription rate and substrate specificity of RNA polymerase II.
T76131	Sarcosine oxidase
	Sarcosine oxidase(SAO)，即肌氨酸氧化酶，可以催化肌氨酸的氧化去甲基化生成甘氨酸，H2O2, 5,10-CH2-四氢叶酸，常用于生化反应。
T64105	Voriconazole camphorsulfonate
	Voriconazole (UK-109496) camphorsulfonate 是一种二代广谱的三唑类抗真菌 (antifungal) 化合物，对真菌麦角甾醇的生物合成表现出抑制作用。Voriconazole camphorsulfonate 能够抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用，表现出抗真菌效果。
T71453	TriN2755
	TriN2755 is a synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. This agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes.
T7866	Difenoconazole	Others; Antifungal	Microbiology/Virology; Others
	Difenoconazole 是一种广谱三唑类杀菌剂，通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成，从而导致真菌细胞膜的破坏和细胞死亡。
T35718	N-desmethyl Rosuvastatin (sodium salt hydrate)
	N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tand...
T72244	CBB1007 trihydrochloride
	CBB1007三盐酸盐是 LSD1选择性抑制剂，IC50值为5.27uM。
T71327	Paraxanthine-d6
	Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni...

化合物

Cat.No: T19721

Synonym: BAS-480F,BAS 480F,EC 406 850 2,氟环唑,BAS480F,EC-406-850-2

Target: Antifungal

Cat.No: T2199

Synonym: Systhane,腈菌唑

Target: Antifungal

Cat.No: T7867

Target: NMDAR, Antifungal

Cat.No: T26829

Synonym: KWG-0599,联苯三唑醇,KWG0599,Baycor,Biloxazol,KWG 0599,Sibutol

Target: Antifungal

Cat.No: T27918

Synonym: LY-43578,LY43578

Target: P450, Aromatase

Propargylcholine

Cat.No: T38173

Synonym: Propargylcholine (bromide)

Target: Antibacterial

Cat.No: T11469

Target: DNA Methyltransferase

Cat.No: T4498

Synonym: 斯利潘托,BCX2600,Diacomit

Target: P450

Sulconazole mononitrate

Cat.No: T6686

Synonym: Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑

Target: Antibacterial, Antibiotic, Antifungal

Cat.No: T5966

Synonym: 己唑醇,(-)-Hexaconazol

Target: Reactive Oxygen Species, Antifungal

Cat.No: T35363

Synonym: 5hmC,5-Hydroxymethylcytosine,5-羟甲基胞嘧啶

Target: Others

Isavuconazonium sulfate

Cat.No: T3934

Target: Antifungal

Oxiconazole nitrate

Cat.No: T1290

Synonym: 硝酸奥昔康唑,Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Melperone hydrochloride

Cat.No: T71926

Cat.No: T69167

Arasertaconazole

Cat.No: T26649

CBB1007 hydrochloride

Cat.No: T72388

5-Formylcytosine

Cat.No: T29453

Sarcosine oxidase

Cat.No: T76131

Voriconazole camphorsulfonate

Cat.No: T64105

Cat.No: T71453

Cat.No: T7866

Target: Others, Antifungal

N-desmethyl Rosuvastatin (sodium salt hydrate)

Cat.No: T35718

CBB1007 trihydrochloride

Cat.No: T72244

Paraxanthine-d6

Cat.No: T71327

Cat. No.	Product Name	Target	Signaling Pathways
T3397	Epmedin C 淫羊霍定C,Baohuoside-VI,Epimedin C	Others	Others
	Epmedin C (Baohuoside-VI) 是天然化合物，在切除卵巢的小鼠体内与雌性激素作用相似。
T10018	1-Methyladenine	Others	Others
	1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes.
T81651	Norrubrofusarin Didemethylasperxanthone
	Norrubrofusarin (Didemethylasperxanthone) 是一种从Aspergillus niger的代谢物 (Compound III) 去甲基化反应中提取的天然产物。

天然产物

Cat.No: T3397

Synonym: 淫羊霍定C,Baohuoside-VI,Epimedin C

Target: Others

1-Methyladenine

Cat.No: T10018

Target: Others

Norrubrofusarin

Cat.No: T81651

Synonym: Didemethylasperxanthone

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