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Search Results for " cytotoxic alkaloid "

4

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T34252	Racemosidine A
	Racemosidine A is a cytotoxic bisbenzylisoquinoline alkaloid from the roots of Cyclea racemosa.
T30869	Chaetominine NSC 746369,NSC-746369,NSC746369
	Chaetominine is a type of cytotoxic alkaloid obtained from endophytic Chaetomium sp. IFB-E015.
T29434	4-Desacetylvinblastine hydrazide DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide
	Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.
T36101	Psychotridine
	Psychotridine is an alkaloid that has been found inP. forsterianaand has diverse biological activities.1,2,3It inhibits ADP-, collagen-, or thrombin-induced aggregation of washed isolated human platelets with IC50values of 1.4, 1.4, and 3.9 μM, respectively.1Psychotridine (2.5 or 5 μM) is cytotoxic to HTC rat hepatocellular carcinoma cells.2It reduces paw licking induced by capsaicin in mice when administered at doses of 0.5, 2.5, or 5 mg/kg.3 1.Beretz, A., Roth-Georger, A., Corre, G., et al.Pol...

化合物

Cat.No: T34252

Cat.No: T30869

Synonym: NSC 746369,NSC-746369,NSC746369

4-Desacetylvinblastine hydrazide

Cat.No: T29434

Synonym: DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide

Cat.No: T36101

Cat. No.	Product Name	Target	Signaling Pathways
T32291	Jineol NSC694081,3,8-Quinolinediol,NSC 694081,NSC-694081	Others	Others
	Jineol (NSC-694081) 是一种来自蜈蚣 Scolopendra subspinipes 的喹啉生物碱。Jineol 在体外对人类肿瘤细胞系的生长具有细胞毒活性。
T3933	Jatrorrhizine Yatrorizine,neprotin,药根碱	MAO; 5-HT Receptor; Antibacterial; AChE	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱，具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。
T4912	Jatrorrhizine chloride 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride	Others; 5-HT Receptor; OCT; Antibacterial; AChE	GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。
T3380	Homoharringtonine Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate	STAT	JAK/STAT signaling; Stem Cells
	Homoharringtonine (HHT) 属于生物碱类天然产物，可以抑制蛋白质的翻译，具有细胞毒性。Homoharringtonine 作用于肿瘤细胞的核糖体，抑制蛋白质翻译的延伸步骤，从而抑制蛋白质合成，具有抗肿瘤活性。
TN3013	4,5-Dimethoxycanthin-6-one Methylnigakinone	P450; Antibacterial; PDE	Metabolism; Microbiology/Virology
	4,5-Dimethoxycanthin-6-one 从 Picrasma quassioides BENNET (Simaroubaceae)是一种从 Picrasma quassioides BENNET (Simaroubaceae) 中分离得到生物碱。4,5-Dimethoxycanthin-6-one 是一种有效的、非竞争性的 CYP1A2 介导的 phenacetin O-deethylation 抑制剂（IC50 ： 1.7 μM, Ki ： 2.6 μM），对环磷酸腺苷（cAMP）磷酸二酯酶有很强的抑制作用。4,5-Dimethoxycanthin-6-one 具有抗菌活性，对金黄色葡萄球菌及其耐药菌株有抑制作用。4,5-Dimethoxycanthin-6-one 对肿瘤细胞株 U937 和 HepG2 具有细胞毒性。
T38429	(+)-Intermedine
	(+)-Intermedine, a pyrrolizidine alkaloid (PA), shows remarkable cytotoxic activity against neural progenitor cells (NPCs).
T39610	Guattegaumerine
	Guattegaumerine, a bisbenzylisoquinoline alkaloid, exhibits antimitotic, cytotoxic, and neuroprotective activities.
T40133	Agrochelin
	Agrochelin, an alkaloid cytotoxic antibiotic, is synthesized via fermentation of a marine Agrobacterium sp. This compound demonstrates cytotoxic activity against tumor cell lines.
T82970	Aristolactam A III Aristololactam A III
	Aristolactam A III (Aristololactam A III) 为一生物碱，具潜在细胞毒性，并可从鱼腥草中分离。
T75698	Xylopine
	Xylopine 是一种具有细胞毒活性的阿朴啡生物碱，能诱导癌细胞氧化应激，从而引发 G2/M 细胞周期停滞及细胞凋亡(apoptosis)。
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...

天然产物

Cat.No: T32291

Synonym: NSC694081,3,8-Quinolinediol,NSC 694081,NSC-694081

Target: Others

Cat.No: T3933

Synonym: Yatrorizine,neprotin,药根碱

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Jatrorrhizine chloride

Cat.No: T4912

Synonym: 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

Homoharringtonine

Cat.No: T3380

Synonym: Myelostat,Ceflatonin,高三尖杉酯碱,HHT,Omacetaxine mepesuccinate

Target: STAT

4,5-Dimethoxycanthin-6-one

Cat.No: TN3013

Synonym: Methylnigakinone

Target: P450, Antibacterial, PDE

(+)-Intermedine

Cat.No: T38429

Guattegaumerine

Cat.No: T39610

Cat.No: T40133

Aristolactam A III

Cat.No: T82970

Synonym: Aristololactam A III

Cat.No: T75698

Cat.No: T37452

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