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Cat. No. | Product Name | Target | Signaling Pathways |
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T8390 |
Cefazolin
头孢唑林,头孢唑啉 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Cefazolin 是一种头孢类抗生素, 用于多种细菌感染的研究。 | |||
T1780 |
Parecoxib
SC 69124,帕瑞昔布,Vorth-P,Valus-P |
COX | Immunology/Inflammation; Neuroscience |
Parecoxib (SC 69124) 是一种有效的选择性 COX-2 抑制剂,是 Valdecoxib 的前药。 | |||
T0953 |
Cefazolin sodium
Ancef,头孢唑啉钠,头孢唑林钠,Cefazolin sodium salt,Sodium cephazolin,cephazolin sodium,cefazoline sodium,Sodium cefazolin |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Cefazolin sodium (cephazolin sodium) salt 是一种头孢类抗生素, 可研究多种细菌感染。 | |||
T1406 |
Amantadine hydrochloride
盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride |
Dopamine Receptor; Influenza Virus | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Amantadine hydrochloride (CI-719) 是一种抗病毒药物,用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。 | |||
T27462 |
GSK-239512
GSK239512,GSK 239512 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
GSK-239512 是 H3 受体拮抗剂,可用于治疗神经退行性疾病认知功能障碍的研究。 | |||
T62839 |
Dalzanemdor
SAGE-718 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Dalzanemdor (SAGE-718) 是 NMDA 受体阳性变构调节剂,可用于研究亨廷顿舞蹈病、阿尔茨海默病和认知功能障碍。 | |||
T60835 |
SKF83959
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
SKF83959 是苯并氮平类化合物,是一种具有选择性和有效性的多巴胺D1受体部分激动剂,对大鼠D1,D5,D2和D3受体的Ki 值分别为 1.18, 7.56, 920 和 399 nM。SKF83959 是 sigma (σ)-1受体的有效变构调节剂,可改善认知功能障碍,用于研究抑郁症和阿尔茨海默病。 | |||
T34751 |
Usmarapride free base
SUVN-D4010,SUVN-D 4010,SUVN-D-1208045,SUVN-1004028,SUVN D4010,SUVN-D1003019 |
||
SUVN-D4010 is an effective, selective, brain penetrant, and orally active agonist of 5-HT4 receptor partially used to treat Alzheimer's disease and other dementia-related cognitive dysfunction. | |||
T30922 |
CI-1002
PD-142676,UNII-7U374ZW3YB |
||
CI-1002 is a novel anticholinesterase and muscarinic antagonist that can be used to treat cognitive dysfunction in AD with fewer peripheral side effects. | |||
T39677 |
MY33-3
MY33-3 |
||
MY33-3 is a powerful and specific inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, demonstrating an IC50 value of approximately 0.1 μM. Moreover, MY33-3 exhibits inhibitory activity against PTP-1B with an IC50 value of about 0.7 μM. Additionally, MY33-3 has been shown to effectively decrease ethanol consumption and alleviate neuroinflammation and cognitive dysfunction induced by Sevoflurane. | |||
T75300 | Cefazolin sodium pentahydrate | ||
Cefazolin sodium pentahydrate 是一代头孢菌素类抗生素,可用于多种细菌感染的研究。Cefazolin sodium pentahydrate 具有抗炎作用,可以减轻术后认知功能障碍 (POCD)。 | |||
T33766 |
OAB-14
OAB 14,OAB14 |
||
OAB-14 是一种 Bexarotene 衍生物,通过清除 APP/PS1 转基因小鼠的 β-淀粉样蛋白,改善其阿尔茨海默病相关的病理学和认知障碍。OAB-14 可有效改善 APP/PS1 转基因小鼠内体自噬溶酶体(EAL)途径的功能障碍。 | |||
T62442 |
MY33-3 hydrochloride
|
||
MY33-3 hydrochloride 是一种有效的、选择性的蛋白酪氨酸磷酸酶 RPTPβ/ζ 抑制剂 (IC50~0.1 μM)。MY33-3 hydrochloride 对 PTP-1B 具有抑制作用 (IC50~0.7 μM)。MY33-3 hydrochloride 能够降低乙醇消耗,缓解 Sevoflurane 引起的神经炎症和认知功能障碍。 | |||
T80106 |
Z-Pro-Pro-aldehyde-dimethyl acetal
|
Prolyl Endopeptidase (PREP) | Metabolism; Proteases/Proteasome |
Z-Pro-Pro-aldehyde-dimethyl acetal 是一种高效的脯氨酸内肽酶(PRE P)抑制剂,其IC50值为12 nM。该化合物在衰老过程和神经退行性疾病,诸如阿尔茨海默病中认知功能障碍的研究中具有重要作用。 | |||
T37013 | (+/-)-PPCC oxalate | ||
Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT. Prezzavento et al (2007) Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 50 951 PMID:17328523 |Prezzavento et al (2008) A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 82 549 PMI... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6975 |
Sarcosine
Sarcosinic acid,Methylaminoacetic acid,Sarcosin,肌氨酸,Methylglycine,N-Methylaminoacetic acid,N-methylglycine |
Others; GlyT; Endogenous Metabolite | Metabolism; Neuroscience; Others |
Sarcosine (Methylglycine) 是 I 型甘氨酸转运蛋白 (GlyT1) 的竞争性抑制剂和 N-甲基-D-天冬氨酸受体 (NMDAR) 共激动剂,通过增加甘氨酸的浓度增强 NMDA 受体的功能,可用于精神分裂症的研究。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 |