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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3279	Silver sulfadiazine Silvadene,磺胺嘧啶银,Dermazin,Flamazine	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Silver sulfadiazine (Dermazin) 是一种磺胺类抗生素，具有抗菌和抗真菌活性。它的通磺胺部分(SD-SDZ) 对细菌生长有双重抑制作用，可阻止细菌叶酸吸收以及 DNA 合成。它释放的银结合并破坏 DNA 结构，阻止细菌 DNA 复制。
T7363	Ibuprofen Piconol U75630,匹美诺芬,布洛芬吡啶甲醇	Others	Others
	Ibuprofen Piconol (U75630) 是非甾体抗炎药物，局部使用可缓解原发性热灼伤和晒伤。
T40888	3-Acetamidocoumarin
	3-Acetamidocoumarin, a compound significant in biology and medicine, exhibits physiological effects and is utilized in treating various conditions, including burns, brucellosis-rheumatic diseases, and cancer.
T31404	Dextranomer Dextranomere,Dextranomero,Debrisan,Dextranomerum
	Dextranomer, for treatment of burns; consists of three-dimensional network of dextran polymers cross-linked by epichlorohydrin; dextranomer based implants usedas a bulking agent for endoscopic treatment of pediatric structural incontinence; ingredient of
T61581	LasR-IN-2
	LasR-IN-2, a compound that inhibits the activity of LasR, forms hydrogen bonding with the TRY-56 residue. It finds application in the study of bacterial infection, neutropenia, severe burns, and chronic lung disease in cystic fibrosis (CF) [1].
T36626	Lys-CoA
	Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo. Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID:10882143 \|Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID:18273021 \|Burns et al (...

化合物

Silver sulfadiazine

Cat.No: T3279

Synonym: Silvadene,磺胺嘧啶银,Dermazin,Flamazine

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Ibuprofen Piconol

Cat.No: T7363

Synonym: U75630,匹美诺芬,布洛芬吡啶甲醇

Synonym: Dextranomere,Dextranomero,Debrisan,Dextranomerum

Cat. No.	Product Name	Target	Signaling Pathways
T2897	(Rac)-Shikonin (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid	Others	Others
	(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。
T3025	Asiaticoside BRN0078195,CCRIS8995,Emdecassol,Ba 2742,Madecassol,积雪草皂苷,NSC166062,积雪草苷	Apoptosis; p38 MAPK; Reactive Oxygen Species; Endogenous Metabolite; TGF-beta/Smad	Apoptosis; Immunology/Inflammation; MAPK; Metabolism; NF-κB; Stem Cells
	Asiaticoside (Emdecassol) 是一种从积雪草中分离得到的三萜皂苷化合物，具有抗氧化、抗炎、抗溃疡等作用。在瘢痕疙瘩成纤维细胞中，它通过活化 Smad7，抑制 TGF-βRI 和 TGF-βRII，抑制 TGF-β/Smad 信号通路。
T4958	(-)-Alkannin Alkannin,左旋紫草素,紫草素,Shikonin	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	(-)-Alkannin (Shikonin) 是从紫朱草中发现的一种天然产物，具有抗癌活性，可抑制细胞周期，诱导细胞凋亡，用作食品着色剂，在 Rho 激酶途径中可改善肝脏炎症。