Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9570 |
Enpatoran
|
TLR | Immunology/Inflammation |
Enpatoran (M5049) 是一种口服有效的TLR7/8选择性抑制剂,在HEK293 细胞中,IC50s 分别为 11.1 nM 和 24.1 nM。Enpatoran 可以阻断分子合成配体和天然内源性 RNA 配体。Enpatoran 在体内具有良好的药代动力学特性。Enpatoran 在先天性和适应性自身免疫阻断方面有研究的价值。 | |||
T28628 |
RVX-297
RVX297 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
RVX-297 是口服具有活性的,对BD2有选择性的BET 高效抑制剂,作用于BRD2(BD2)、BRD3(BD2)、BRD4(BD2) 的IC50分别为 0.08、0.05、0.02 μM。它能够阻碍多种免疫细胞炎症基因的表达,对临床前模型急性炎症及自身免疫均有效。 | |||
T1237 |
Azathioprine
硫唑嘌呤,BW 57-322 |
Apoptosis; GPR; Rho | Apoptosis; Cell Cycle/Checkpoint; Endocrinology/Hormones; GPCR/G Protein |
Azathioprine (BW 57-322) 是一种免疫抑制剂。 | |||
T7657 |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat
髓鞘少突胶质细胞糖蛋白,MOG (35-55) |
Others | Others |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) 是中枢神经鞘的一个次要成分。它能诱导强效的 T 细胞和 B 细胞反应,同时是高度脑源性的。它能够引发复发缓解性神经系统疾病,伴有广泛的斑块样脱髓鞘。 | |||
T30077 |
Anisperimus
LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195 |
Caspase | Apoptosis; Proteases/Proteasome |
Anisperimus (LF 15-0195) 是一种免疫抑制剂,通过促进 DISC 水平的 caspase-8 和 caspase-10 激活来增强激活诱导的 T 细胞死亡,通过促进表达 Foxp3 的调节性 CD4 T 细胞的发育来预防中枢神经系统自身免疫。 | |||
T37077 |
Syk-IN-4
|
||
Syk-IN-4 is a potent, selective, and orally bioavailable inhibitor of SYK, demonstrating an IC50 of 0.31 nM. It targets SYK, which has been identified as a potential therapeutic target for autoimmunity and hematological cancers[1]. | |||
T11889 | LTV-1 | Others | Others |
LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. | |||
T63814 |
IDO2-IN-1
|
||
IDO2-IN-1 是一种口服活性的强效IDO2抑制剂,其IC50为112 nM。该化合物适用于炎症性自身免疫研究。 | |||
T11559 |
HG-12-6
|
Others | Others |
HG-12-6 is a type II inhibitor of IRAK4. HG-12-6 shows preferential binding to unphosphorylated inactive IRAK4 (IC50: 165 nM). HG-12-6 can modulate IRAK4 activity in autoimmunity and inflammation. | |||
T80573 |
Firastotug
|
||
Firastotug为针对CTLA4的IgG1κ抗体。CTLA4作为细胞毒性T淋巴细胞相关抗原,它在自身免疫和癌症研究中扮演着重要的免疫检查点角色。 | |||
T77074 | Lulizumab pegol | ||
Lulizumab pegol (BMS-931699) 为一种抗CD28抗体拮抗剂,能有效抑制T细胞增殖。其主要应用于肾移植和自身免疫性疾病的研究。 | |||
T75254 | P2X7-IN-2 TFA | ||
P2X7-IN-2 TFA(化合物58)为P2X7受体抑制剂,以IC50为0.01 nM抑制IL-Iβ释放,适用于自身免疫病、炎症及心血管疾病研究。 | |||
T79151 | TLR8 agonist 6 | ||
TLR8 agonist6 (Compound A),具有EC50值为0.052 μM的TLR8激动特性,能够以EC50为0.031 μM的效力促进人PBMC中的IL-12p40生成。适用于抗病毒、抗感染、自身免疫和肿瘤相关研究领域。 | |||
T73335 |
P2X7-IN-2
|
||
P2X7-IN-2 是P2X7受体抑制剂。P2X7-IN-2 抑制 IL-Iβ 的释放,IC50值为 0.01 nM。P2X7-IN-2 可用于自身免疫病,炎症以及心血管疾病的研究。 | |||
T37287 |
Enpatoran hydrochloride
|
||
Enpatoran (M5049) hydrochloride is a potent and orally active dual inhibitor of TLR7/8 with IC50 values of 11.1 nM and 24.1 nM in HEK293 cells, respectively. This compound specifically inhibits TLR7 and TLR8, while showing no activity against TLR3, TLR4, and TLR9. Enpatoran hydrochloride has the ability to block both synthetic molecule ligands and natural endogenous RNA ligands. Additionally, it demonstrates excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be a valuable ... | |||
T81772 |
MOG (92–106), mouse, rat
|
||
MOG (92–106), mouse, rat 是一种来自小鼠/大鼠髓磷脂少突胶质细胞糖蛋白的生物活性肽,包含氨基酸片段92至106。在MOG (92–106) 诱导的实验性自身免疫性脑脊髓炎模型中,小鼠会对次级髓磷脂抗原呈现出广泛的B细胞反应性,尽管T细胞反应较弱。该肽段在SJL小鼠、DA大鼠以及恒河猴中均可诱导严重的脑炎。 |