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Search Results for " anxiolytic-like effects "

14

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19916	TRIM 1-(2-Trifluoromethylphenyl)imidazole,1-(2-三氟甲基苯基)咪唑	NOS	Immunology/Inflammation
	TRIM (1-(2-Trifluoromethylphenyl)imidazole) 是一氧化氮合酶抑制剂。它在体外能够抑制小鼠小脑 nNOS (IC50:28.2 µM)，以及大鼠肺 iNOS (IC50:27.0 µM)。它拥有抗焦虑以及抗抑郁的能力。
T16421	p-MPPI hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	p-MPPI hydrochloride 是一种选择性的，具有高亲和力的5-HT1A 受体拮抗剂，能穿过血脑屏障，具有抗抑郁和抗焦虑样作用。
T16408	Osanetant SR142801	Others	Others
	Osanetant produces anxiolytic- and antidepressant-like effects. Osanetant is a selective NK3 receptor antagonist. It is researched for schizophrenia.
T27744	KRM-II-81 KRM-II81,KRM-II 81
	KRM-II-81 is a γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand. KRM-II-81 exhibits improved anxiolytic-like effects in a mouse marble burying assay and a rat Vogel conflict test.
T40205	Posovolone Co 134444
	Posovolone (Co 134444), an orally active neuroactive steroid with sedative-hypnotic properties, exhibits anticonvulsant and anxiolytic-like activities, alongside ataxic effects.
TP1557	Urocortin II, human TFA
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor. Human urocortin II exhibits mild motor-suppressive effects and delayed anxiolytic-like effects，suggesting a time-depen
T37823	M 084 hydrochloride
	TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo. Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID:25816897 \|Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136...
T61506	NBI-31772 hydrate
	NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-I/IGFBP-3 complex (Ki values for all six human subtypes range from 1-24 nM). This compound demonstrates significant anxiolytic and antidepressant-like effects [1] [2] [3].
T74413	(S)-Osanetant
	(S)-Osanetant 是 Osanetant 的S 对映体。Osanetant (SR142801) 是一种选择性的NK3受体拮抗剂。Osanetant 有抗焦虑和抗抑郁的作用，并被研究用于精神分裂症。
T73568	MTEP
	MTEP，一种非竞争性且高选择性的mGluR5拮抗剂，具有显著的抗抑郁和抗焦虑效果，亦被用于帕金森疾病的研究。
TP2136	(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
	Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and indu
T80424	Phoenixin-20 TFA PNX-20 TFA	Epigenetic Reader Domain	Chromatin/Epigenetic
	Phoenixin-20 (TFA) (PNX-20 (TFA)) 是一种在脊椎动物中发挥激素作用的生物活性肽，能够激活下丘脑-垂体-性腺轴，从而调控哺乳类动物的生殖机能。此外，该肽通过CREB-PGC-1α途径，增强神经元的线粒体生物生成。
T75832	Cyclotraxin B TFA
	Cyclotraxin B TFA 是一种环肽，是一种高效且选择性的 TrkB 抑制剂，且不会改变 BDNF 的结合。Cyclotraxin B TFA 非竞争性地抑制 BDNF 诱导的 TrkB 活性，IC50值为 0.30 nM。Cyclotraxin B TFA 可以穿越血脑屏障，并具有止痛和抗焦虑的行为作用。
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...

化合物

Cat.No: T19916

Synonym: 1-(2-Trifluoromethylphenyl)imidazole,1-(2-三氟甲基苯基)咪唑

Target: NOS

p-MPPI hydrochloride

Cat.No: T16421

Target: 5-HT Receptor

Cat.No: T16408

Synonym: SR142801

Target: Others

Cat.No: T27744

Synonym: KRM-II81,KRM-II 81

Cat.No: T40205

Synonym: Co 134444

Urocortin II, human TFA

Cat.No: TP1557

M 084 hydrochloride

Cat.No: T37823

NBI-31772 hydrate

Cat.No: T61506

Cat.No: T74413

Cat.No: T73568

(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin

Cat.No: TP2136

Phoenixin-20 TFA

Cat.No: T80424

Synonym: PNX-20 TFA

Target: Epigenetic Reader Domain

Cyclotraxin B TFA

Cat.No: T75832

Cat.No: T38145

Cat. No.	Product Name	Target	Signaling Pathways
T8014	Epoxylinalool 氧化芳樟醇,2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran	Others	Others
	Epoxylinalool (2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran) 是一种天然存在的单萜醇，广泛用于香水和调味品的生产。
T6S2227	Spinosin 斯皮诺素,Flavoayamenin	Others	Others
	Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮，从 Zizyphus jujube 种子分离得到，能够激活 Nrf2/HO-1 通路，并抑制 Aβ1-42的产生和聚合。
TN4322	Isopulegol	ATPase; Potassium Channel; GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper...

天然产物

Cat.No: T8014

Synonym: 氧化芳樟醇,2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran

Target: Others

Cat.No: T6S2227

Synonym: 斯皮诺素,Flavoayamenin

Target: Others

Cat.No: TN4322

Target: ATPase, Potassium Channel, GABA Receptor

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