12
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0488 |
Finasteride
非那雄胺,MK-906 |
Reductase | Endocrinology/Hormones; Metabolism |
Finasteride (MK-906) 是 5α-还原酶的竞争性抑制剂,对 II 型 5α-还原酶的IC50为 4.2 nM,对 II 型 5α-还原酶的亲和力是 I 型酶的 100 倍。它可用于研究前列腺增生和雄激素性脱发。 | |||
T17256 |
Wnt pathway activator 1
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Wnt pathway activator 1 是Wnt 激活剂(EC50=28-29 nM)。 | |||
T21444 |
Diphenylcyclopropenone
DPCP,Diphencyprone,二苯基环丙烯酮 |
Others | Others |
Diphenylcyclopropenone (DPCP) 是局部免疫调节剂,可用于研究斑秃。 | |||
T27798 |
Lapisteride
CS891B,CS-891,CS-891B,CS891 |
Others | Others |
Lapisteride (CS-891) 一种类固醇5α-还原酶抑制剂,可用于治疗良性前列腺增生(BPH)和雄激素性脱发,可有效预防或治疗AGA 。 | |||
T10889 |
CRTh2 antagonist 2
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
CRTh2 antagonist 2 是一种有效的选择性 CRTH2 抑制剂,对 CRTH2 的 IC50 值为 ≤10 nM。CRTh2 antagonist 2 可用于雄激素性脱发的研究。 | |||
T28358 |
PF 00277343
PF-00277343,PF00277343 |
||
PF 00277343, a thyroid receptor agonist, is used for the treatment of androgenetic alopecia. | |||
T10636 | 5α-reductase-IN-1 | Others | Others |
5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in combination with minoxidil, a well-known treatment for hair loss. | |||
T38467 | (Rac)-PF-998425 | ||
(Rac)-PF-998425 is a potent, selective, nonsteroidal antagonist of the androgen receptor (AR), with IC50 values of 26 nM and 90 nM in AR binding and cellular assays, respectively. This compound shows promise for investigating androgenetic alopecia. | |||
T27519 |
GW 9578
GW9578,GW-9578 |
PPAR | DNA Damage/DNA Repair; Metabolism |
GW 9578 是一种具有选择性和有效性的 PPARα 激动剂 ,具有有效的降脂活性,可用于研究牛皮癣,关节炎,脱发,哮喘和I型糖尿病。 | |||
T82202 | H-Gly-Leu-Phe-OH | ||
H-Gly-Leu-Phe-OH (GLF)为源于α-乳白蛋白的三肽,具有免疫刺激性,能够抑制抗癌药物依托泊苷所引起的脱发、表皮增厚以及脂肪细胞层的变薄。 | |||
T21668 | Finasteride acetate | ||
Finasteride (MK-906) acetate 是一种高效的5α-还原酶 (5α-reductase) 竞争性抑制剂,其对 II 型 5α-还原酶的IC50值仅为 4.2 nM,其对该型酶的亲和力是对 I 型酶亲和力的约100倍。因此,Finasteride acetate 主要在良性前列腺增生症 (BPH) 和雄激素性脱发研究领域中应用。 | |||
T61029 | TP0427736 hydrochloride | ||
TP0427736 hydrochloride 可用于雄激素性脱发 (AGA) 研究。TP0427736 hydrochloride 可抑制由 TGF-β1 诱导的 A549 细胞中 Smad2/3 的磷酸化,IC50值为 8.68 nM。它也是ALK5激酶的有效抑制剂,IC50值为 2.72 nM,比对 ALK3 836 nM 的抑制作用高 300 倍。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21936 |
M50054
2,2′-亚甲基双(1,3-环己二酮) |
Caspase | Apoptosis; Proteases/Proteasome |
M50054 是一种有效的细胞凋亡抑制剂,可用于研究抗 Fas 抗体引起的肝炎和化疗引起的脱发。它抑制 Etoposide 诱导的 U937 细胞 caspase-3 活化,IC50为 79 μg/mL。 | |||
T3378 |
Alpha-Estradiol
α-雌二醇,Alfatradiol,雌二醇,17α-Estradiol,Epiestrol,Epiestradiol |
Estrogen/progestogen Receptor; Reductase; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Alpha-Estradiol (Epiestradiol) 是一种雌性激素,可抑制5α-reductase,在雄原性脱发的研究中有潜力。 |