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Cat. No. | Product Name | Target | Signaling Pathways |
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T8533 |
ML318
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Others; Antibiotic | Microbiology/Virology; Others |
ML318 是 PvdQ 酰基转移酶的联芳基腈抑制剂,可以结合在酰基结合位点上,IC50为 20 nM。它抑制铜绿假单胞菌的 IC50为 19 μM。它可防止嘧啶的产生并限制了铜绿假单胞菌在铁限制条件下的生长。 | |||
T4681 |
T863
DGAT-3,DGAT-1 inhibitor |
Acyltransferase; Transferase | Metabolism |
T863 (DGAT-3) 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A 结合位点,抑制三酰甘油在细胞内的合成。 | |||
T60774 |
NITD-916
NITD916,NITD 916 |
Antibiotic | Microbiology/Virology |
NITD-916 是一种具有口服活性和高度亲脂性的分枝杆菌烯酰还原酶 InhA 抑制剂,IC50 为 570 nM。NITD-916是一种有有效的 4-羟基-2-吡啶酮衍生物, 与 InhA 和 NADH 形成三元复合物,阻止进入脂肪酰基底物结合袋。NITD-916 具有抗结核活性。 | |||
T36578 |
Boc-Lys(Ac)-AMC
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Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. GPR132/G2A is first reported to be a transcriptional target for BCR-ABL tyrosine kinase attenuating B-cell expansion in vitro and arresting cells at G2 during mitosis. It has been involved in autoimmune disease and atherosclerosis. [1]... | |||
T38011 |
C2 Adamantanyl Globotriaosylceramide (d18:1/2:0)
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C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. It inhibits Vero toxin binding to globotriaosylceramide in an ELISA assay when used at a concentration of 10 μM. AdaGb3 decreases cell surface expression of P-glycoprotein (P-gp) and reduces efflux of rhodamine 123 in MDCK cells. It also increases apical-to-basal transport of vinblastine in human intestinal ... | |||
T83125 | AMPK-α1β1γ1 activator 1 | AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
AMPK-α1β1γ1激活剂1 (M1) 是一个衍生于Indole-3-carcinoma的酰基葡萄糖醛酸代谢AMPK激活剂,专一性地针对人类β1亚型,表现出38.1nM的EC50值。该化合物能够直接结合至人AMPK α1β1γ1亚型,适用于糖尿病肾病的相关研究。 | |||
T36764 |
PAF C-18:1
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PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration. PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recogn... | |||
T37684 |
CAY10412
CAY10412 |
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Anandamide (arachidonoyl ethanolamide; AEA) is an endogenous lipid with cannabinergic activity; along with 2-arachidonoyl glycerol, it forms part of the endocannabinoid system. AEA undergoes reuptake into neurons by a facilitated process. Controversy exists as to whether there is a specific AEA transporter, or instead the uptake process is simply driven by hydrolysis of AEA by intracellular fatty acyl amide hydrolase (FAAH). CAY10412 is an analog of AEA that has no intrinsic binding affinity for... | |||
T37582 |
Ganglioside GM1 Mixture (ovine) (ammonium salt)
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Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0912L |
Tetracycline
Deschlorobiomycin,Tetracyclinum,Tetracyclin,四环素 |
Others; ribosome; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Tetracycline (Tetracyclin) 是一种对多种革兰氏阳性和革兰氏阴性细菌有抑制活性的广谱抗生素。 |