14
7
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2164 |
Wiskostatin
|
Others | Others |
Wiskostatin 是神经元 Wiskott-Aldrich 综合征蛋白介导的肌动蛋白聚合的选择性抑制剂,能够不可逆的使细胞 ATP 水平快速下降。 | |||
T23372 |
SMIFH2
|
Others | Others |
SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合,影响肌动蛋白细胞骨架。 | |||
T22260 |
Aminopurvalanol A
|
CDK | Cell Cycle/Checkpoint |
Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的Cyclins/Cdk 复合物抑制剂,优先靶向G2/M 期转变进而抑制癌细胞分化。它通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。 | |||
T5007 |
Benproperine phosphate
磷酸苯丙哌林,Blascorid,Pirexyl phosphate |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的,肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移,有用于治疗止咳的潜力。 | |||
T1820 |
CK-636
CK-0944636,CK 636 |
Microtubule Associated | Cytoskeletal Signaling |
CK-636 (CK-0944636)是一种具有细胞渗透性的Arp2/3复合体抑制剂,能抑制肌动蛋白的聚合,对人,裂殖酵母和牛的IC50值分别为4、24 和 32 μM。 | |||
T36358 |
Diminutol
|
||
Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization. | |||
T36402 |
Kibdelone C
|
||
Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro. | |||
TP1977 |
187-1, N-WASP inhibitor
|
||
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization | |||
T83715 |
Histatin 3 TFA
Hst-3 |
||
Histatin 3, 一种唾液抗菌肽,对C. albicans具有活性(LC50 = 9.2 µM)。在12 µM浓度下,还能在无细胞测定中诱导肌动蛋白聚合。 | |||
T73498 |
EG-011
|
||
EG-011为首创且有效的Wiskott-Aldrich综合症蛋白(WASP)激活剂, 通过促进肌动蛋白聚合以激活WASP的自抑制形式。此化合物展现出对淋巴瘤的选择性抗癌活性。 | |||
T82934 | AuM1Phe | Topoisomerase | DNA Damage/DNA Repair |
AuM1Phe是一种N-杂环卡宾(NHC)金属络合物,其作用机制包括抑制人类拓扑异构酶I活性和阻碍肌动蛋白聚合。在MDA-MB-231乳腺癌细胞上,AuM1Phe展现了抑制细胞生长的效果,具有1.2 μM的IC50值。 | |||
T69269 |
DMGF
|
||
DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). MGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization DMGF may be further developed to... | |||
T65390 |
Fluvoxketone
|
||
Fluvoxketone is trifluoromethyl-substituted aryl ketone compound useful as an intermediate in the synthesis of Fluvoxamine, which is a selective serotonin reuptake inhibitor. In the synthesis of Fluvoxamine, the ketone carbonyl of Fluvoxketone is elaborated to an oxime.In vitro,the inhibitory effect of fluvoxamine on actin polymerization was concentration dependent, and its IC50 was approximately 30 μM.In vivo,fluvoxamine treated EAE rats showed a decrease in IFN-γ serum levels and an increase i... | |||
T82252 |
GTPγS tetralithium
|
||
GTPγS (tetralithium) 是一种G蛋白激活剂,能够通过酪氨酸激酶依赖性机制刺激GLUT4的转位,并促进磷脂酶活化和肌动蛋白的聚合,从而可以作为蛋白质抑制蛋白酶介导降解的保护剂。此外,GTPγS (tetralithium) 在研究G蛋白α亚单位功能和激酶活性时可以与其结合使用,并可用作裂解缓冲液中的一个组分。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13864 |
Resolvin D1
RvD1 |
Apoptosis | Apoptosis |
Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质,可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移,减少 TNF-α 介导的炎症在巨噬细胞中的作用,并增强巨噬细胞对凋亡细胞的吞噬作用。 | |||
T5S1981 |
alpha-Cyperone
(+)-α-Cyperone,α-香附酮,α-Cyperone |
Others; Endogenous Metabolite | Metabolism; Others |
alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。 | |||
T35609 |
19-O-Acetylchaetoglobosin A
|
||
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ... | |||
T15721 |
Latrunculin A
LAT-A |
Others | Others |
Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin, and G-actin, re | |||
T10928 |
Cytochalasin A
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy | |||
T20636 |
Latrunculin B
LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644 |
Antifungal | Microbiology/Virology |
Latrunculin B 是一种 来自红海海绵的生物碱,是一种肌动蛋白聚合 (actin polymerization) 抑制剂,具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生,可用于研究青少年青光眼。 | |||
T11712 |
Jasplakinolide
Jaspamide,NSC-613009 |
Microtubule Associated; Antifungal | Cytoskeletal Signaling; Microbiology/Virology |
Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽,是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性,可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白,对 F-肌动蛋白的 Kd 值为 15 nM。 |