31
5
Cat. No. | Product Name | Target | Signaling Pathways |
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T40541 |
α-Synuclein (61-75)
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α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disease (PD). | |||
T4659 |
ELN484228
|
Others | Others |
ELN484228 是一种 α-突触核蛋白的阻断剂。α-突触核蛋白是帕金森病中的关键蛋白质。 | |||
T76861 |
Cinpanemab
BIIB054 |
Others | Others |
Cinpanemab (BIIB054) 是一种新型人源单克隆抗体,对 α-突触核蛋白 1-10 位残基具有亲和力。Cinpanemab 可用于研究帕金森及其相关疾病。 | |||
T63321 |
20S Proteasome activator 1
|
Proteasome | Proteases/Proteasome; Ubiquitination |
20S Proteasome activator 1 是一种 20S 蛋白酶激活剂,对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。 | |||
T62226 | Dyrk1A/α-synuclein-IN-2 | ||
Dyrk1A/α-synuclein-IN-2 (Compound b20) 是一种双重的 Dyrk1A 和α-synuclein aggregation 的抑制剂,能够作用于α-synuclein (IC50: 7.8 μM)。Dyrk1A/α-synuclein-IN-2 具有较高的预测 CNS 渗透性和神经保护作用。 | |||
T62096 | Dyrk1A/α-synuclein-IN-1 | ||
Dyrk1A/α-synuclein-IN-1 (Compound b1) 是一种双重的 Dyrk1A (IC50: 177 nM) 和 α-synuclein aggregation (IC50: 10.5 μM) 抑制剂。Dyrk1A/α-synuclein-IN-1 表现出较好的预测 CNS 渗透性和神经保护活性。 | |||
T62131 |
α-Synuclein inhibitor 5
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α-Synuclein inhibitor 5 是一种有效的、能够透过血脑屏障的 α-Synuclein (α-Syn) 聚集的抑制剂 (IC50: 1.22 μM),在 30 μM 时的抑制率为 94.3%。 | |||
T78629 |
PROTAC α-synuclein degrader 3
|
PROTACs | PROTAC |
PROTACα-synuclein degrader 3 (compound 5) 为高效的选择性 PROTACα-synuclein 降解剂,适用于帕金森病研究。 | |||
T19838 |
Brilliant Blue R250
Acid Blue 83,Brilliant Blue R,Coomassie Brilliant Blue R250,CBBR,Coomassie Brilliant Blue R |
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CBBR is an inhibitor of wild type and mutant alpha-synuclein aggregation. CBBR also a modulator of neurotoxicity. | |||
T61644 | α-Synuclein inhibitor 6 | ||
α-Synuclein inhibitor 6 (compound 3ge) is a highly effective and blood-brain barrier-permeable inhibitor that targets the aggregation of α-Synuclein (α-Syn). It exhibits a potent inhibitory activity, with an IC50 value of 1.70 μM, leading to a remarkable inhibition ratio of 94.4% at 30 μM [1]. | |||
T83726 |
Tat-βsyn-degron TFA
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Tat-βsyn-degron是一种降低α-synuclein表达的肽。其结构包括HIV-1 Tat质膜跨导域、与β-synuclein氨基酸36-45相对应的α-synuclein结合域βsyn,以及蛋白酶体定向域degron。Tat-βsyn-degron能够与重组α-synuclein结合,并在大鼠初级皮质神经元培养中降低α-synuclein水平。 | |||
T76199 |
α-Synuclein (61-75) (TFA)
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α-Synuclein(61-75) TFA 是α-Synuclein 的 61-75 片段。α-Synuclein 是一种丰富的神经元蛋白,在突触前神经末梢高度丰富。α-Synuclein 是一种帕金森氏病 (PD) 的生物标志物。 | |||
T13049 |
Synucleozid
NSC 377363 |
Others | Others |
Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease. | |||
T61404 |
α-Synuclein inhibitor 3
|
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α-Synuclein inhibitor 3 (Compound 7g) is a potent inhibitor of α-synuclein (α -Syn) aggregation. It has potential applications in Parkinson's disease research [1]. | |||
T61611 |
α-Synuclein inhibitor 4
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α-Synuclein inhibitor 4 (compound 3gh) is a highly effective and blood-brain barrier-permeable inhibitor of α-Synuclein aggregation. It displays potent activity, with an IC50 value of 0.98 μM, and exhibits a remarkable inhibition ratio of 91.2% at a concentration of 30 μM [1]. | |||
T78842 | α-Synuclein inhibitor 9 | ||
α-Synuclein inhibitor9 (Compound 20C) 是一种针对 α-Synuclein 的抑制剂,通过与成熟 α-Synuclein 原纤维内的空腔结合,减少了 β-折叠构型,并有效阻止 A53T α-Syn 的聚集。由于其神经保护性质,该化合物能够改善大脑功能性连接并缓解运动障碍,适用于帕金森病 (PD) 的相关研究。 | |||
T81031 |
tau protein/α-synuclein-IN-1
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tau protein/α-synuclein-IN-1为tau protein与α-synuclein双重抑制剂,能够抑制M17D神经母细胞瘤细胞中α-syn包涵体的形成,适用于阿尔茨海默病相关研究。 | |||
T79250 |
PROTAC α-synuclein degrader 5
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PROTACs | PROTAC |
PROTACα-synuclein degrader 5为针对α-synuclein聚集体的高度选择性小分子(PROTAC),具有DC50值为7.51 μM和最大降解率Dmax达89%。该化合物结合了探针分子sery308与E3 ligase链接剂,适用于神经系统疾病研究。 | |||
T76889 | Prasinezumab | ||
Prasinezumab (PRX 002) 为针对聚集α-突触核蛋白 (α-synuclein) 的人源化IgG1单克隆抗体,展现在帕金森病研究中的应用潜力。 | |||
T71174 |
PBT434 HBr
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PBT434 is a novel, brain-penetrant, small molecule inhibitor of α-synuclein aggregation. In transgenic animal models of Parkinson disease (A53T) and MSA (PLP-α-Syn), PBT434 reduced α-synuclein aggregation, preserved neurons and improved motor function. Glial cell inclusions were also reduced in a murine MSA model. PBT434 is thought to act by redistributing reactive iron across membranes, thereby blocking intracellular protein aggregation and oxidative stress. The affinity of PBT434 for iron is g... | |||
T13049L |
Synucleozid hydrochloride (502139-01-7 free base)
Synucleozid hydrochloride,NSC 377363 hydrochloride |
Others | Others |
Synucleozid hydrochloride is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease. | |||
T74974 | SQ-3 | ||
SQ-3为一种喹啉类似物,对α-syn聚合体(Ki=39.3 nM)显示中等选择性,其选择性高于对β-淀粉样蛋白(Aβ)聚合体(Ki=230 nM)。[18F]SQ3展现出作为α-syn成像探针的先导化合物的基本属性。 | |||
T83875 |
HUP-55
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HUP-55是一种脯氨酸内肽酶的抑制剂(IC50 = 5 nM)。在10 µM的浓度下,它可减少Neuro2a细胞中α-突触核蛋白二聚体的形成,促使HEK293细胞发生自噬,并降低SH-SY5Y细胞中由过氧化氢诱导的反应性氧种(ROS)产量的增加。此外,HUP-55(10 mg/kg)在通过腺病毒递送α-突触核蛋白编码载体(AAV-αSyn)诱导的帕金森病小鼠模型中,能减少患侧爪的使用和纹状体中寡聚体α-突触核蛋白水平。 | |||
T78171 |
QR-0217
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QR-0217是一种有效的Aβ1-40聚集抑制剂,具有7.5 µM的IC50值,阻断α-突触核蛋白的聚集,并可减轻Aβ神经毒性导致的记忆障碍。 | |||
T70941 |
CLR01 sodium
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CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS. CLR01 inhibits Ebola and Zika virus infection. CLR01 Stabilizes a Disordered Protein-Protein Interface. CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity. | |||
T75361 | BSB | ||
BSB,一种刚果红衍生的荧光探针,既与细胞外淀粉样β蛋白发生结合,也能与由异常tau蛋白与突触核蛋白组成的细胞内病变相结合,是作为阿尔茨海默病原型成像剂的代表。 | |||
T74770 | D-685 | ||
D-685作为D-520的前体药物,在帕金森病(PD)血脂化动物模型中展示了优于D-520的体内抗PD功效。此外,D-685能降低人类α-突触核蛋白(α-syn)的累积,且具有更高的大脑透过性。 | |||
T83328 |
4A7C-301
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4A7C-301是一种Nurr1激动剂,体外显示出强大的神经保护能力。在AAV2介导的α-突触核蛋白过表达雄鼠模型中,该化合物能显著纠正神经病理学异常,并改善运动及嗅觉功能障碍。此外,4A7C-301适用于帕金森病相关研究。 | |||
T37533 |
DOPAL
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DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as wel... | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
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Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... | |||
T83894 |
4A7C-301-Nurr1 Agonist
4A7C-301-Nuclear Receptor-Related 1 |
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4A7C-301-Nurr1激动剂是一种核受体相关1(Nurr1)的激动剂。它通过与Nurr1配体结合域(LBD;IC50 = 48.22 nM)结合,增加了在使用SK-N-BE(2)C人神经母细胞瘤细胞进行的报告基因测定中Nurr1-LBD和全长Nurr1的转录活性(EC50s = 6.53 和 50-70 µM,分别)。每天5 mg/kg的4A7C-301-Nurr1激动剂能减少在经MPTP神经毒素或α-突触核蛋白过表达诱导的帕金森病鼠模型中纹状体和黑质compacta部分多巴胺能细胞的死亡,并减少运动和嗅觉缺陷,而不诱发类似运动障碍的行为。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T7441 |
Cuminaldehyde
Cuminic aldehyde,4-异丙基苯甲醛,Cuminal |
Endogenous Metabolite | Metabolism |
Cuminaldehyde (Cuminal) 是一种具有抑制 α-突触核蛋白纤颤和细胞毒性作用的天然醛,是一种 Cuminum cyminum 的主要成分。它显示抗癌特性。 | |||
T5S0658 |
Corynoxine
柯诺辛,柯诺辛碱 |
Autophagy | Autophagy |
Corynoxine 是从大叶钩藤中分离出的一种四环羟吲哚生物碱。它是一种自噬增强剂,可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。 | |||
T5S2357 |
Acetylcorynoline
(+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵 |
Antifungal | Microbiology/Virology |
Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分,具有抗炎活性。 | |||
T72962 |
Sycosterol A
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Sycosterol A 是一种α-synuclein(α-syn)甾醇抑制剂。 | |||
T75438 | Corynoxine hydrochloride | ||
Corynoxine hydrochloride 是一种从Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂,可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。 |