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Search Results for " wogonin "

3

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T126265	Norwogonin-8-O-glucuronide
	Norwogonin-8-O-glucuronide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126265。
T36744	CDK9 Antagonist-1 CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9\|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
T17728	PROTAC CDK9 degrader-2	Others	Others
	PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].

化合物

Norwogonin-8-O-glucuronide

Cat.No: T126265

CDK9 Antagonist-1

Cat.No: T36744

Synonym: CDK9 Antagonist-1

PROTAC CDK9 degrader-2

Cat.No: T17728

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2933	Wogonin Vogonin,汉黄芩素	Apoptosis; Wnt/beta-catenin; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Wogonin (Vogonin) 是一种具有细胞渗透性的口服类黄酮，具有抗炎和抗癌特性，能够抑制 CDK8和 Wnt 的活性。
T3318	Wogonoside 汉黄芩苷,Glychionide B,Wogonin 7-O-glucuronide,Oroxindin	GABA Receptor; Autophagy	Autophagy; Membrane transporter/Ion channel; Neuroscience
	Wogonoside (Wogonin 7-O-glucuronide) 是从黄芩中分离得到的一种黄酮类天然产物，具有抗炎作用。它是 GABAA 受体苯二氮卓位点的正变构调节剂，可通过调节 MAPK-mTOR 通路诱导乳腺癌细胞的自噬。
T13966	Wogonin 7-O-beta-D-glucuronide methyl ester Wogonoside methyl ester	Others	Others
	Wogonin 7-O-beta-D-glucuronide methyl ester is a natural product isolated from Huanglian Jiedutang.
T8205	Norwogonin 5,7,8-Trihydroxyflavone,去甲汉黄芩素	Virus Protease	Microbiology/Virology
	Norwogonin (5,7,8-Trihydroxyflavone) 是从黄芩中分离出来的，对肠道病毒 71 具有抗病毒活性，IC50为 31.83 μg/ ml。
TN3096	6-Methoxywogonin	Others	Others
	6-Methoxywogonin shows weak anti-inflammatory effect.
TN1276	4'-Hydroxywogonin 5,7,4'-trihydroxy-8-methoxyflavone,4'-羟基汉黄芩素	Others	Others
	4'-Hydroxywogonin has positive effect on inhabiting those human tumor lines in vitro, with IC50 value is 8.3-38.4ug/mL .
TN3173	6-Hydroxywogonin	Others	Others
	6-Hydroxywogonin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3173，CAS号为 76844-70-7。

天然产物

Cat.No: T2933

Synonym: Vogonin,汉黄芩素

Target: Apoptosis, Wnt/beta-catenin, CDK, Autophagy

Cat.No: T3318

Synonym: 汉黄芩苷,Glychionide B,Wogonin 7-O-glucuronide,Oroxindin

Target: GABA Receptor, Autophagy

Wogonin 7-O-beta-D-glucuronide methyl ester

Cat.No: T13966

Synonym: Wogonoside methyl ester

Target: Others

Cat.No: T8205

Synonym: 5,7,8-Trihydroxyflavone,去甲汉黄芩素

Target: Virus Protease

6-Methoxywogonin

Cat.No: TN3096

Target: Others

4'-Hydroxywogonin

Cat.No: TN1276

Synonym: 5,7,4'-trihydroxy-8-methoxyflavone,4'-羟基汉黄芩素

Target: Others

6-Hydroxywogonin

Cat.No: TN3173

Target: Others

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