Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T23523 |
W-5 hydrochloride
W-5 HCl,盐酸W-5,W 5 (hydrochloride),N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl |
CaMK | Neuroscience |
W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) 一种有效的钙调素拮抗剂。 | |||
T6080 |
NVP-AEW541
AEW541 |
FLT; Tyrosine Kinases; IGF-1R; Autophagy | Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors |
NVP-AEW541 (AEW541) 是一种IGF-1R 抑制剂,IC50为 0.15 μM。它也抑制InsR,IC50为 0.14 μM。 | |||
T9766 |
GW590735
|
PPAR | DNA Damage/DNA Repair; Metabolism |
GW590735 是一种有效的选择性 PPARα 激动剂,对 PPARα 的 EC50 为 4 nM,比 PPARδ 和 PPARγ 的选择性至少高 500 倍。 GW590735 可用于血脂异常研究。 | |||
TP2131L |
Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
|
Rho | Cell Cycle/Checkpoint |
Rac1 Inhibitor W56 acetate(1095179-01-3 free base) 包含 Rac1 的鸟嘌呤核苷酸交换因子 (GEF) 识别/激活位点的残基 45-60 的肽;选择性抑制 Rac1 与 Rac1 特异性 GEF TrioN、GEF-H1 和 Tiam1 的相互作用。 | |||
T69408 | GW590735 sodium | ||
GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively. | |||
T71082 |
DW532
|
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DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human ca... | |||
T18106 | m-PEG-OH (MW5000) | Others | Others |
m-PEG-OH (MW5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | |||
T69682 |
AEW541 HCl
|
||
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder sc... | |||
T75932 |
Rac1 Inhibitor W56 TFA
|
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Rac1 Inhibitor W56 TFA,为Rac1中残基45-60的抑制剂,能够阻止Rac1与鸟嘌呤核苷酸交换因子TrioN、GEF-H1及Tiam的相互作用。 | |||
T27510 |
GW568377A
|
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GW568377A is an inhibitor of Mer Kinase and EGFR. | |||
TP2131 |
Rac1 Inhibitor W56
|
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Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1. | |||
T83901 |
BDW568
|
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BDW568是一种刺激素干扰素基因(STING)的激动剂,同时是BDW-OH的前药形式。在使用THP-1细胞的报告基因测定中,它能诱导STING转录活性(EC50 = 7.6 µM)。BDW568(50 µM)在THP-1细胞中诱导TANK结合激酶1(TBK1)和IFN调节因子3(IRF3)的磷酸化。 |