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Cat. No. Product Name Target Signaling Pathways
T1583 Vorinostat

MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA

Apoptosis; Mitophagy; Virus Protease; HDAC; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
Vorinostat (SAHA) 是一种泛的组蛋白脱乙酰酶 (HDAC) 抑制剂 (IC50=10 nM),对 HDAC1/2/3/6/7/11 均有抑制活性。 Vorinostat 具有抗肿瘤活性,可以诱导细胞分化,阻滞细胞周期,诱导细胞凋亡。
T19556 SAHA chloroalkane T1

Others Others
SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting in the formation of SAHA chloroalkane T1.
T79407 HL23

Others Others
HL23是一种HDAC抑制剂,对抗HCC具有活性。通过增强TXNIP启动子乙酰化,此化合物上调TXNIP表达,进而介导钾通道活性并触发TXNIP依赖性钾剥夺,抑制HCC的进展和转移。HL23与Sorafenib联合应用时显示出协同作用,并且其效力超过Sorafenib与Vorinostat的联用。
T70779 BPR1J-340

BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD(+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibit...
T70195 NL-103

NL-103 is a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. NL-103 comprises structural elements of Hh pathway inhibitor vismodegib, and histone deacetylase (HDAC) inhibitor vorinostat. NL-103 simultaneously and significantly inhibited both HDACs and Hh pathway. Importantly, NL-103 effectively overcame vismodegib resistance induced by Smoothened point mutations. Moreover, NL-103 significantly dow...

化合物

Vorinostat
Cat.No: T1583
Synonym: MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA
Target: Apoptosis, Mitophagy, Virus Protease, HDAC, Autophagy
SAHA chloroalkane T1
Cat.No: T19556
Synonym:
Target: Others
HL23
Cat.No: T79407
Synonym:
Target: Others
BPR1J-340
Cat.No: T70779
Synonym:
Target:
NL-103
Cat.No: T70195
Synonym:
Target:
TargetMol Loading
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