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Cat. No. Product Name Target Signaling Pathways
T2382 Vemurafenib

RO5185426,RG7204,维罗非尼,PLX4032

Raf; MAPK; ACK; Src; Autophagy Angiogenesis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
Vemurafenib (RG7204) 是一种 B-RAF 抑制剂,可以抑制 RAFV600E 和 c-RAF-1 (IC50=31/48 nM),具有选择性和有效性。Vemurafenib 具有抗肿瘤活性,用于 BRAF V600E 突变阳性的黑色素瘤治疗。
T8654 Plx-4032

维罗非尼,Vemurafenib

Raf MAPK
Plx-4032 (Vemurafenib) 是一种小分子 B-Raf 抑制剂,可用于治疗恶性黑色素瘤。
T27551 Honokiol DCA

Honokiol Bis-Dichloroacetate

Honokiol DCA is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrating activity in Vemurafenib-resistant melanoma in vivo.
T27537 Hexafluoro

Hexafluoro is an inhibitor of DRP1 phosphorylation. Honokiol DCA stimulates a phenotype suggestive of respiration through mitochondrial normalization and demonstrates activity in Vemurafenib-resistant melanoma in vivo.
T70424 EBI-907

EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E)-dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases i...
T78777 Vem-L-Cy5

Raf MAPK
Vem-L-Cy5 (化合物3)是一款改造自Vemurafenib的BRAF抑制剂, 其结构通过近红外荧光团Cy5进行修饰。该化合物针对BRAFV600E具有特异性,并能有效阻断MEK的磷酸化作用。Vem-L-Cy5展现了良好的细胞内渗透能力,并能抑制多种癌细胞系的生长。
T63210 Everafenib

Everafenib 是有效的、能够透过血脑屏障的 BRAF 抑制剂,对 MAPK 通路也具有抑制作用。Everafenib 能够抑制一系列 V600EBRAF 黑色素瘤细胞系的活性 (IC50: 2-10 nM),且效果比Dabrafenib 和Vemurafenib 好。Everafenib 可有效延长颅内转移性黑色素瘤小鼠模型的存活天数。

化合物

Vemurafenib
Cat.No: T2382
Synonym: RO5185426,RG7204,维罗非尼,PLX4032
Target: Raf, MAPK, ACK, Src, Autophagy
Plx-4032
Cat.No: T8654
Synonym: 维罗非尼,Vemurafenib
Target: Raf
Honokiol DCA
Cat.No: T27551
Synonym: Honokiol Bis-Dichloroacetate
Target:
Hexafluoro
Cat.No: T27537
Synonym:
Target:
EBI-907
Cat.No: T70424
Synonym:
Target:
Vem-L-Cy5
Cat.No: T78777
Synonym:
Target: Raf
Everafenib
Cat.No: T63210
Synonym:
Target:
TargetMol Loading
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