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Cat. No.	Product Name	Target	Signaling Pathways
T6716	Valsartan Diovan,缬沙坦,Tareg,CGP 48933	RAAS	Endocrinology/Hormones
	Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
T2318	Sacubitril/Valsartan Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696	Apoptosis; RAAS; Neprilysin	Apoptosis; Endocrinology/Hormones; Metabolism
	Sacubitril/Valsartan (LCZ696)，以1:1摩尔比由Valsartan（一种ARB）和Sacubitril（AHU377）组成，为创新口服血管紧张素受体-脑啡肽酶（ARN）双重抑制剂，旨在治疗高血压与心力衰竭。其作用机制包括抑制炎症、氧化应激及细胞凋亡，有助于改善糖尿病心肌病。
T20564	Valsartan benzyl ester Valsartan impurity B,Valsartan related compound C
	Valsartan benzyl ester is a intermediate of Valsartan.
T67848	Valsartan Methyl Ester	RAAS	Endocrinology/Hormones
	Valsartan Methyl Ester 是一种强效血管紧张素II 受体拮抗剂，IC50=0.06uM。
T35725	4-hydroxy Valsartan
	4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan . It reduces platelet aggregation induced by epinephrine and collagen but not ADP in human whole blood.
T13283	Valsartan Ethyl Ester	Others	Others
	Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
T13282	Valsartan-d9 CGP-48933 D9,缬沙坦 D9	Others	Others
	Valsartan D9 is a deuterium-labeled valsartan. Valsartan is an antagonist of the angiotensin II receptor and for the treatment of high blood pressure and heart failure.
T68890	Desvaleryl Valsartan
	Desvaleryl valsartan is a potential impurity found in commercial preparations of the angiotensin II type 1 (AT1) receptor antagonist valsartan. It is a degradation product formed under acidic conditions.
T4200	Sacubitril hemicalcium salt AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt	Neprilysin	Metabolism
	Sacubitril hemicalcium salt (AHU377 calcium salt) 是一种有效的 NEP 抑制剂，IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。
T20126	Losartan potassium impurity E L-158507,L 158507,L158507
	Losartan potassium impurity E is a compound of Valsartan impurity.
T19113	2S,4R-Sacubitril	Others	Others
	2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.
T19111	2R,4R-Sacubitril	Others	Others
	2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.
T19622	(Z)2S,4R-Sacubitril	Others	Others
	(Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is used in combination with valsartan for the treatment of patients with heart failure.
T4574L	Sacubitril sodium AHU377,AHU-377,LCZ696,AHU 377
	Sacubitril is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases.

化合物

Cat.No: T6716

Synonym: Diovan,缬沙坦,Tareg,CGP 48933

Target: RAAS

Sacubitril/Valsartan

Cat.No: T2318

Synonym: Sacubitril mixture with Valsartan,沙库必曲/缬沙坦,Valsartan,Sacubitril,LCZ696

Target: Apoptosis, RAAS, Neprilysin

Valsartan benzyl ester

Cat.No: T20564

Synonym: Valsartan impurity B,Valsartan related compound C

Valsartan Methyl Ester

Cat.No: T67848

Target: RAAS

4-hydroxy Valsartan

Cat.No: T35725

Valsartan Ethyl Ester

Cat.No: T13283

Target: Others

Cat.No: T13282

Synonym: CGP-48933 D9,缬沙坦 D9

Target: Others

Desvaleryl Valsartan

Cat.No: T68890

Sacubitril hemicalcium salt

Cat.No: T4200

Synonym: AHU-377 (hemicalcium salt),LCZ696中间体,AHU377 calcium salt

Target: Neprilysin

Losartan potassium impurity E

Cat.No: T20126

Synonym: L-158507,L 158507,L158507

2S,4R-Sacubitril

Cat.No: T19113

Target: Others

2R,4R-Sacubitril

Cat.No: T19111

Target: Others

(Z)2S,4R-Sacubitril

Cat.No: T19622

Target: Others

Sacubitril sodium

Cat.No: T4574L

Synonym: AHU377,AHU-377,LCZ696,AHU 377

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