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35

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T73617	Urate oxidase
	Urate oxidase (Uox) 尿酸氧化酶，即尿酸酶，常用于生化研究。Urate oxidase 是一种过氧化物酶，在大多数哺乳动物中催化尿酸氧化为尿囊素。
T15160	Dotinurad (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone	OAT	Membrane transporter/Ion channel
	Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) 是有效的尿酸盐重吸收选择性抑制剂，抑制尿酸盐转运蛋白 1的IC50为 37.2 nM，具有促尿酸排泄的作用。
T3994	Verinurad RDEA3170,维立诺雷	OAT	Membrane transporter/Ion channel
	Verinurad (RDEA3170) 是一种有效的、特异性的URAT1抑制剂，IC50为 25 nM。
T6875	Lesinurad RDEA594,雷西那德,来司诺雷	OAT	Membrane transporter/Ion channel
	Lesinurad (RDEA594) 是URAT1和OAT 抑制剂。Lesinurad 用作肾转运蛋白OAT1 和OAT3 的底物，Km 分别为 0.85 和 2 μM。
T20545	Benzarone Benzarona,Vasoc,苯扎隆,Venagil,Benzaronum	OAT	Membrane transporter/Ion channel
	Benzarone (Benzarona) 是人尿酸转运蛋白 1的有效抑制剂，IC50为 2.8 μM。它具有降低血清尿酸水平的作用。
T22443	Triglycidyl isocyanurate Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI	Apoptosis	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物，可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡，具有抗血管生成和抗肿瘤活性，用于癌症研究。
T1145	Diminazene Aceturate	Others; Serine Protease; Parasite	Microbiology/Virology; Others; Proteases/Proteasome
	Diminazene aceturate 是血管紧张素转化酶 2 的激活剂，具有强效抗炎特性。它还是一种抗锥虫药物，适用于牲畜。它主要生化机理是通过与富含腺嘌呤-胸腺嘧啶碱基对的位点发生特异性相互作用，以非插入方式与锥虫动子体 DNA 结合。
T8365	Methenamine Hippurate	Antibacterial	Microbiology/Virology
	Methenamine hippurate 是一种口服活性尿液广谱抗菌剂。它对大多数常见的尿路病原体有效。
T5039	Aminohippurate sodium Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,4-氨基马尿酸钠盐,p-Aminohippuric acid sodium salt	Others	Others
	Aminohippurate sodium (Sodium p-aminohippurate) 是能够利用肾血浆流量测量肾脏医学测试的诊断剂。
T38612	Linaprazan glurate	Others	Others
	Linaprazan glurate 抑制外源性或内源性刺激的胃酸分泌。 Linaprazan glurate 可用于胃肠道炎症性疾病和消化性溃疡疾病的研究。
T1526	Nifuratel NF 113,SAP 113,硝呋太尔,Methylmercadone	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Nifuratel (SAP 113) 是广谱抗生素，有抗细菌、真菌和毛滴虫活性。
T13388L	Zaurategrast ethyl ester UCB1184197,CDP323	Others	Others
	Zaurategrast ethyl ester is the ethyl ester prodrug of CT7758 and is an α4β1/α4β7 integrin antagonist. It is used for the treatment of inflammatory and autoimmune disorders.
T20598	Sorbitan monolaurate Emasol L 10,Emasol L-10,Arlacel20,Arlacel-20,Arlacel 20,Emasol L10
	Sorbitan monolaurate, a non-ionic surfactant, is widely used as a stabilizer and emulsifier in pharmaceutical formulations, food, and cosmetic industries.
T33881	Paracetamol mercapturate
	Paracetamol mercapturate is a deuterated metabolite of acetaminophen.
T25931	Pentachlorophenyl laurate NSC-77542,Mystox LPL,NSC 77542,NSC77542
	Pentachlorophenyl laurate is used as a pesticide.
T33785	o-Iodohippurate sodium Hippodin,NSC-63351,Sodium iodohippurate NSC 63351,NSC63351
	o-Iodohippurate sodium is an analogue of p-aminohippuric acid used to determine effective renal plasma flow. Labelled OIH has a higher clearance than other radiopharmaceutical yet developed and is extremely suitable for renography. It is eliminated mainly
T30976	Clofibrate mercapturate
	Clofibrate mercapturate is a urinary metabolite of clofibrate.
T30003	Ammonium acryloyldimethyltaurate
	Ammonium acryloyldimethyltaurate is a bioactive chemical.
T32080	Histidine oxoglurate Histidine alpha-ketoglutarate
	Histidine oxoglurate is a bioactive chemical.
T17286	Zaurategrast CT7758	Others	Others
	Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.
T36469	Atrazine Mercapturate
	Atrazine mercapturate is a major, glutathione-derived metabolite of atrazine , an herbicide that is effective in controlling a broad range of weeds. Atrazine has been reported to cause cancer in certain laboratory animals, have diverse effects on the reproductive system in animals and humans, and disrupt the normal function of the endocrine system. Atrazine mercapturate is readily measured in urine samples.
T40438	PEG-8 laurate
	PEG-8 laurate is a monofunctional surfactant and skin penetration enhancer. It disrupts the skin barrier and facilitates the formation of elastic vesicles when synthesized.
T33907	PEG-9 Laurate NSC 1249,Lipal 4L,NSC-1249,Lipal 4ML,NGML
	PEG-9 Laurate is a bioactive chemical.
T20215	Acetaminophen mercapturate
	Paracetamol Mercapturate is a metabolite of Acetaminophen. It can also be used in the biological study of urinary antihypertensive drugs.
T34813	Testosterone ketolaurate Testosterone 3-oxododecanoate,Testosteroni ketolauras,十二酮酸睾酮
	Testosterone ketolaurate is an androgen and anabolic steroid and a testosterone ester.
T31683	Estrofurate AY-11,483,AY-11483,AY 11483-16
	Estrofurate is a biochemical.
T13388	Zaurategrast ethyl ester sulfate UCB1184197 sulfate,CDP323 sulfate	Others	Others
	Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.
T0435	Sulfinpyrazone (+/-)-Sulfinpyrazone,G-28315,苯磺保泰松,NSC 75925	COX	Immunology/Inflammation; Neuroscience
	Sulfinpyrazone (NSC-75925) 是一种口服有效的尿酸剂，具有抗血栓和血小板抑制作用。它可作用于慢性和间歇性痛风性关节炎。
T61048	Puliginurad YL-90148	OAT	Membrane transporter/Ion channel
	Puliginurad (YL-90148) 是一种具有有效性和选择性的尿酸盐转运蛋白 (URAT) 抑制剂，对尿酸的重吸收有抑制作用。Puliginurad 可用于预防和治疗高尿酸血症和痛风。
T62593	Xininurad
	Xininurad (XNW3009) 是一种尿酸盐转运子 (URAT) 抑制剂。
T68298	Oteracil
	Oteracil is an antagonist of urate oxidase.
T60724	URAT1 inhibitor 3
	URAT1 inhibitor 3 是具有口服活性的URAT1的选择性抑制剂(IC 50 = 0.8 nM)。URAT1 inhibitor 3 显示出降低尿酸的功效，可用于研究痛风和高尿酸血症。
T72632	URAT1 inhibitor 4
	URAT1 inhibitor4 是一种Lesinurad 的衍生物，是口服有效的URAT1抑制剂，IC50为 7.56 μM。URAT1 inhibitor4具有比Lesinurad 更高的体内降尿酸效力。
T27275	Epaminurad
	Epaminurad (UR-1102) 是一种口服有效的和选择性的URAT1(尿酸转运体 1) 抑制剂，其Ki 为 0.057 μM。Epaminurad 适度地抑制OAT1和OAT3(有机阴离子转运体)。Epaminurad 是一种促尿酸排泄剂。Epaminurad 可用于痛风和高尿酸血症的研究。
T79177	URAT1&XO inhibitor 2	Xanthine Oxidase	Metabolism
	URAT1&XO inhibitor 2 (Compound BDEO)是一种针对xanthine oxidase (黄嘌呤氧化酶) 及URAT1的双重抑制剂，对xanthine oxidase展现出优异的抑制效果，IC50值为3.3 μM。该化合物在表达URAT1的HEK293细胞中显著抑制尿酸的摄取，其Ki值达到0.145 μM。在动物模型中，URAT1&XO inhibitor 2有效降低高尿酸血症小鼠的血清尿酸水平，并增加尿酸的排泄。该化合物主要用于高尿酸血症的研究。

化合物

Urate oxidase

Cat.No: T73617

Cat.No: T15160

Synonym: (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone

Target: OAT

Cat.No: T3994

Synonym: RDEA3170,维立诺雷

Target: OAT

Cat.No: T6875

Synonym: RDEA594,雷西那德,来司诺雷

Target: OAT

Cat.No: T20545

Synonym: Benzarona,Vasoc,苯扎隆,Venagil,Benzaronum

Target: OAT

Triglycidyl isocyanurate

Cat.No: T22443

Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI

Target: Apoptosis

Diminazene Aceturate

Cat.No: T1145

Target: Others, Serine Protease, Parasite

Methenamine Hippurate

Cat.No: T8365

Target: Antibacterial

Aminohippurate sodium

Cat.No: T5039

Synonym: Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,4-氨基马尿酸钠盐,p-Aminohippuric acid sodium salt

Target: Others

Linaprazan glurate

Cat.No: T38612

Target: Others

Cat.No: T1526

Synonym: NF 113,SAP 113,硝呋太尔,Methylmercadone

Target: Antibacterial, Antibiotic, Parasite

Zaurategrast ethyl ester

Cat.No: T13388L

Synonym: UCB1184197,CDP323

Target: Others

Sorbitan monolaurate

Cat.No: T20598

Synonym: Emasol L 10,Emasol L-10,Arlacel20,Arlacel-20,Arlacel 20,Emasol L10

Paracetamol mercapturate

Cat.No: T33881

Pentachlorophenyl laurate

Cat.No: T25931

Synonym: NSC-77542,Mystox LPL,NSC 77542,NSC77542

o-Iodohippurate sodium

Cat.No: T33785

Synonym: Hippodin,NSC-63351,Sodium iodohippurate NSC 63351,NSC63351

Clofibrate mercapturate

Cat.No: T30976

Ammonium acryloyldimethyltaurate

Cat.No: T30003

Histidine oxoglurate

Cat.No: T32080

Synonym: Histidine alpha-ketoglutarate

Cat.No: T17286

Synonym: CT7758

Target: Others

Atrazine Mercapturate

Cat.No: T36469

Cat.No: T40438

Cat.No: T33907

Synonym: NSC 1249,Lipal 4L,NSC-1249,Lipal 4ML,NGML

Acetaminophen mercapturate

Cat.No: T20215

Testosterone ketolaurate

Cat.No: T34813

Synonym: Testosterone 3-oxododecanoate,Testosteroni ketolauras,十二酮酸睾酮

Cat.No: T31683

Synonym: AY-11,483,AY-11483,AY 11483-16

Zaurategrast ethyl ester sulfate

Cat.No: T13388

Synonym: UCB1184197 sulfate,CDP323 sulfate

Target: Others

Cat.No: T0435

Synonym: (+/-)-Sulfinpyrazone,G-28315,苯磺保泰松,NSC 75925

Target: COX

Cat.No: T61048

Synonym: YL-90148

Target: OAT

Cat.No: T62593

Cat.No: T68298

URAT1 inhibitor 3

Cat.No: T60724

URAT1 inhibitor 4

Cat.No: T72632

Cat.No: T27275

URAT1&XO inhibitor 2

Cat.No: T79177

Target: Xanthine Oxidase

Cat. No.	Product Name	Target	Signaling Pathways
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
T41242	Uric acid sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂，是一种有效的、常见的抗氧化剂，有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，对脂质过氧化有抑制作用，与痛风性关节病的发病机理和草酸钙结石的形成有关。
TN6895	Methyl Laurate 月桂酸甲酯,methyl dodecanoate	Others	Others
	Methyl Laurate (methyl dodecanoate) 是月桂酸的酯化产物，是一种 12 碳饱和脂肪酸。
T30004	Ammonium laurate AI3 00287,AI3-00287,AI300287
	Ammonium laurate is a surfactant.

天然产物

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

Uric acid sodium

Cat.No: T41242

Target: Reactive Oxygen Species

Cat.No: TN6895

Synonym: 月桂酸甲酯,methyl dodecanoate

Target: Others

Ammonium laurate

Cat.No: T30004

Synonym: AI3 00287,AI3-00287,AI300287

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