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Search Results for " th2 cells "

13

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3965	Fevipiprant QAW039,NVP-QAW039,非维匹仑	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Fevipiprant (NVP-QAW039) 是一种选择性、强效、可逆的竞争性 CRTh2 拮抗剂，KD 值为1.1 nM，IC50为0.44 nM，能够引发人体嗜酸性粒细胞的形状变化。
T14565	BI-671800 AP-761,Cmpd A	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	BI-671800 (AP-761) 是高特异性的前列腺素 D2 受体拮抗剂，对哮喘有研究潜力，对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC50值分别为 4.5 和 3.7 nM。
T3520	Setipiprant KYTH-105,塞替匹仑,ACT-129968	GPR; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation
	Setipiprant (ACT-129968) 是一种口服的选择性 CRTH2 拮抗剂，IC50为6.0 nM。
T4674	SB297006 SB 297006	CCR	Immunology/Inflammation; Microbiology/Virology
	SB297006 是一种CCR3拮抗剂，IC50为39 nM。它能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。
T82882	Binetrakin
	Binetrakin (Interleukin 4 (human)) 是一种多效性细胞因子，源自T淋巴细胞，具有影响包括B细胞和T细胞在内的多种细胞类型的能力。它促进Th0细胞向Th2细胞的分化，广泛应用于各类生物学研究。
T64013	RPT193
	RPT193 是一种口服具有活力的 CCR4 抑制剂，对 Th2 炎性免疫细胞募集到炎症组织表现出抑制作用，在特应性皮炎、哮喘、过敏性炎症等疾病中发挥着重要作用。
T35450	α-GalCer analog 8 α-GalCer analog 8,α-Galactosylceramide analog 8
	α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 &#181g per animal dose, indicati...
T62944	CCR8 antagonist 2
	CCR8 antagonist 2 是一种 CCR8 的有效拮抗剂，能够抑制的 CCR8 活性。CCR8 (C-C Motif 趋化因子受体 8) 主要表达于 Treg 细胞和 Th2 细胞，且不在 Th1 细胞上表达。CCR8 antagonist 2 能够用于由 CCR8 介导的疾病（如癌症和/或神经性疼痛）的治疗。
T62860	YM-341619
	YM-341619 (AS1617612) 是一种有效的、口服具有活力的 STAT6 抑制剂 (IC50: 0.70 nM)。YM-341619 能够抑制 IL-4 诱导的小鼠脾脏 T 细胞 Th2 分化，其 IC50 值为 0.28 nM，但不会影响 Th1 细胞的分化。YM-341619 是一种具有潜力的、能够用于过敏性疾病（如过敏性哮喘）研究的化合物。
T64300	Vimirogant hydrochloride
	Vimirogant (VTP-43742) hydrochloride 是一种口服具有活力的、选择性的 RORγt 抑制剂 (IC50: 17 nM, Ki: 3.5 nM)，选择性比 RORα 和 RORβ 大于 1000 倍。Vimirogant hydrochloride 能够抑制小鼠脾细胞的 Th17 分化和 IL-17A 分泌，其 IC50 值为 57 nM，且不影响 Th1，Th2 或 Treg 细胞的分化。Vimirogant hydrochloride 能够用于自身免疫性疾病的研究。
T64265	JAK1/TYK2-IN-3
	JAK1/TYK2-IN-3 是一种选择性的、有效的、口服具有活力的 TYK2 (IC50: 6 nM) 和 JAK1 (IC50: 37 nM) 双重抑制剂。JAK1/TYK2-IN-3 能够选择性的作用于 JAK2 和JAK3，其 IC50 值为 140 nM 和 362 nM。JAK1/TYK2-IN-3 能够调节 TYK2/JAK1 相关基因的表达，并调节 Th1 、Th2 和 Th17 细胞的形成，发挥其抗炎活性。
T38365	CAY10597
	The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the...
T36984	Cyclic di-IMP (sodium salt)
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p...

化合物

Cat.No: T3965

Synonym: QAW039,NVP-QAW039,非维匹仑

Target: GPR, Prostaglandin Receptor

Cat.No: T14565

Synonym: AP-761,Cmpd A

Target: GPR, Prostaglandin Receptor

Cat.No: T3520

Synonym: KYTH-105,塞替匹仑,ACT-129968

Target: GPR, Prostaglandin Receptor

Cat.No: T4674

Synonym: SB 297006

Target: CCR

Cat.No: T82882

Cat.No: T64013

α-GalCer analog 8

Cat.No: T35450

Synonym: α-GalCer analog 8,α-Galactosylceramide analog 8

CCR8 antagonist 2

Cat.No: T62944

Cat.No: T62860

Vimirogant hydrochloride

Cat.No: T64300

Cat.No: T64265

Cat.No: T38365

Cyclic di-IMP (sodium salt)

Cat.No: T36984

Cat. No.	Product Name	Target	Signaling Pathways
T2S2173	(E)-Naringenin chalcone Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮	Others	Others
	Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体，在查耳酮异构酶的作用下，自发代谢成柚皮素。它具有抗炎和抗过敏活性。
T38838	QS-21 Stimulon,QS-21
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.
TN4778	Physalin H	gp120/CD4; Antifection; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both

天然产物

(E)-Naringenin chalcone

Cat.No: T2S2173

Synonym: Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮

Target: Others

Cat.No: T38838

Synonym: Stimulon,QS-21

Cat.No: TN4778

Target: gp120/CD4, Antifection, Autophagy

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