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39

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T32597	Lauricycline Tetracycline lauryl sulfate
	Lauricycline is a bioactive chemical.
T69631	DDA-tetracycline
	DDA-tetracycline, also known CMT-1 and 4-Des-dimethylaminotetracycline, is a Matrix Metalloproteinase Inhibitor.
T21508	Anhydrotetracycline hydrochloride	Antibacterial; Antibiotic	Microbiology/Virology
	Anhydrotetracycline hydrochloride 是四环素的生物合成前体，是广谱的、有效的竞争性四环素破坏酶抑制剂。它是真核细胞中四环素控制的基因表达系统的效应子。
T5189	Omadacycline PTK 0796,Amadacycline	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Omadacycline (Amadacycline) 是一种具有口服活性的氨基甲基环素抗菌剂，是四环素类抗生素。它与 30S 核糖体亚基结合，抑制细菌蛋白质合成。它可用于研究急性细菌性皮肤和皮肤结构感染，感染性肺炎和尿路感染。
T21081	Chlortetracycline Biomycin,Chlormax,7-Chlorotetracycline,Acronize,氯四环素,Aureomycin,Aureomycin A-377
	Chlortetracycline is a broad-spectrum antibiotic tetracycline with a 7-chloro substitution. It inhibits growth of both Gram-negative and Gram-positive bacteria by inhibiting protein synthesis.
T36599	4-Epianhydrotetracycline hydrochloride
	Epianhydrotetracycline (EATC) is a degradation product of the antibiotic tetracycline .1 EATC is active against Pseudomonas, Agrobacterium, Moraxella, Bacillus, and E. coli (MIC50s = 0.75-16 mg/L).
T35425	β-Apooxytetracycline
	β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Baci...
T37965	4-Epitetracycline hydrochloride
	Epitetracycline is an epimer of the antibiotic tetracycline . Epimers of tetracycline form without catalysis and are considered degradation products. Epitetracycline has decreased activity as an antibiotic or a Tet repressor effector but may have stronger toxic effects in animals.
T74194	Anhydrotetracycline
	Anhydrotetracycline (5a(6)-Anhydrotetracycline)为四环素失活酶的小分子抑制剂，可抵抗四环素类抗生素的酶降解作用。该化合物在表达四环素破坏酶的全细胞大肠杆菌中有效恢复四环素活性。
T36595	4-epi-Chlortetracycline (hydrochloride)
	Chlortetracycline is an analog of tetracycline , a broad spectrum antibiotic. In addition to its actions against microorganisms, chlortetracycline suppresses inflammation by inhibiting neutrophil action and other aspects of the innate immune response. 4-epi-Chlortetracycline is an epimer of chlortetracycline.
T75282	Oxytetracycline calcium
	Oxytetracycline calcium 是一种属于四环素类的抗生素。Oxytetracycline calcium 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline calcium 是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline calcium 还具有抗HSV-1的活性。
T41353	4-Epioxytetracycline

T34137	Prolinomethyltetracycline PMTC,PM-TC,PM TC
	Prolinomethyltetracycline is a hormone.
T35950	4-Epianhydrochlortetracycline (hydrochloride)
	4-Epianhydrochlortetracycline (hydrochloride) 可用于生命科学领域的相关研究。其产品编号为 T35950，CAS号为 158018-53-2。
T38337	Isochlortetracycline
	Isochlortetracycline 是广谱抗生素金霉素降解的无活性碱性产物。
T2469	TP808 TP-808,TP 808	Others	Others
	TP808是一种高度通用的中间体，可用于多种四环素类抗生素的构建。
T3052	Sancycline Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline	Antibacterial	Microbiology/Virology
	Sancycline (Bonomycin) 是半合成四环素，通过可逆地结合 30S 核糖体亚基并通过阻断氨酰-tRNA 进入核糖体 A 位点来抑制蛋白质翻译。
T1569	Tigecycline 替加环素,GAR-936	ribosome; Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Tigecycline (GAR-936) 是甘氨酰环素抗生素，对 Acinetobacter baumannii(A. baumannii) 的 MIC50和 MIC90分别为 1 和 2 mg/L。它对 E. coli(MG1655 菌株) 的平均抑制浓度 (MIC) 约 125 ng/ mL。
T1101	Minocycline hydrochloride Minocycline HCl,盐酸米诺环素,美满霉素	HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Minocycline hydrochloride (Minocycline HCl) 是四环素抗生素，具有出色的吸收和组织渗透性，可用于多种细菌感染以及痤疮的治疗。米诺环素可导致在开始治疗后 1 至 3 个月内发生的急性肝炎样综合征或通常在长期治疗后具有自身免疫特征的更隐匿的慢性肝炎。
T23956	Dactylocycline A
	Dactylocyclines A is novel tetracycline derivatives produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp.
T28661	Sarecycline free base WC3035,P 005672,P005672,WC 3035,WC-3035,P-005672	Others	Others
	Sarecycline free base (P005672) 是一种四环素衍生的窄谱抗生素。
T31185	Dactylocyclinone Sch 34164
	Dactylocycline is a novel tetracycline derivative produced by Dactylosporangium SP. The dactylocyclines are active against some tetracycline - resistant organisms.
T20164	Lymecycline Limeciclina,Mucomycin,Tetralisal
	Lymecycline is a semisynthetic antibiotic. It is related to TETRACYCLINE.
T23957	Dactylocycline B
	Dactylocyclines B is a novel tetracycline derivative produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp.
T24867	Tetramycin 24-Demethyl-24-ethyltetrin A,Tetramycin A,JA-3789
	Tetracycline is an antibiotic agent.
T31184	Dactylocycline E
	Dactylocyclines are novel tetracycline derivatives produced by Dactylosporangium SP. The fermentation of Dactylosporangium sp. (ATCC 53693) produced a mixture of tetracycline derivatives, from which several related tetracycline glycosides, known as rings,
T3052L	Sancycline HCl 6-Demethyl-6-deoxytetracycline,GS-2147,GS2147,GS 2147,NSC 51812 (as hydrochloride),Bonomycin
	Sancycline is a semi-synthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (MIC90s = 1 and 32 μg/ml, respectively).
T20753	Omadacycline tosylate
	Omadacycline tosylate is a new tetracycline.
T68614	Doxycycline fosfatex
	Doxycycline is a synthetic tetracycline derivative with similar antimicrobial activity. Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gramnegative bacteria. Doxycycline has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections.
T23958	Dactylocycline D
	Dactylocyclines D is novel tetracycline derivatives produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp.
T71266	Omadacycline HCl
	Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The pri...
T71903	Meclocycline
	Meclocycline is a tetracycline antibiotic with broad antimicrobial activity. Meclocycline inhibits lactate dehydrogenase (LDH) release and cell toxicity induced by expression of htt-N63-148Q, a mutant form of the huntingtin gene, without altering htt-N63-148Q protein levels in PC12 cells.
T37914	Pipacycline
	Pipacycline is a tetracycline antibiotic derivative. It inhibits the formation of penicillinase, the enzyme that inactivates penicillin in bacteria. It decreases oxygen uptake and inhibits growth of penicillin-resistant penicillinase-producing S. aureus.
T1140	Doxycycline hydrochloride Doxylin,盐酸多西环素,Vibramycin,Hyclate	MMP; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome
	Doxycycline hydrochloride (Hyclate) 是一种四环素抗生素，是口服有效的广谱金属蛋白酶抑制剂，具有抗菌活性。
T21394	Sarecycline hydrochloride P005672,P-005672,WC-3035,WC 3035,Sarecycline HCl,WC3035,P 005672
	Sarecycline, a novel and tetracycline-derived antibiotic, is being developed for use as an oral once daily antibiotic treatment for patients suffering from moderate to severe acne vulgaris. Sarecycline has anti-inflammatory activity and the potential for
T1400L	Demeclocycline Ledermycin,Bioterciclin,Deteclo,Declostatin,Deganol	Antibacterial	Microbiology/Virology
	Demeclocycline (Declostatin) 是一种四环素类抗生素，产自金霉素链霉菌（Streptomyces aureofaciens）菌株。Demeclocycline 具有抗菌活性，能抑制血管加压素对肾小管的作用，从而导致利尿。Demeclocycline 可用诱导尿崩症和急性肾衰竭。
T70250	Demeclocycline calcium
	Demeclocycline calcium is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.
T35437	(-)-Viriditoxin
	(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity. It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml). (-)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MI...
T37006	Previridicatumtoxin
	Previridicatumtoxin is a fungal metabolite that has been found inP. aethiopicumand has diverse biological activities.1,2It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistantS. aureus(MRSA) and vancomycin-resistantE. faecalis(IC50s = 4.4 and 4.8 μM, respectively), as well asC. albicansandS. cerevisiae(MIC = 32 μg/ml for both).2,1It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μ...

化合物

Cat.No: T32597

Synonym: Tetracycline lauryl sulfate

DDA-tetracycline

Cat.No: T69631

Anhydrotetracycline hydrochloride

Cat.No: T21508

Target: Antibacterial, Antibiotic

Cat.No: T5189

Synonym: PTK 0796,Amadacycline

Target: ribosome, Antibacterial, Antibiotic

Chlortetracycline

Cat.No: T21081

Synonym: Biomycin,Chlormax,7-Chlorotetracycline,Acronize,氯四环素,Aureomycin,Aureomycin A-377

4-Epianhydrotetracycline hydrochloride

Cat.No: T36599

β-Apooxytetracycline

Cat.No: T35425

4-Epitetracycline hydrochloride

Cat.No: T37965

Anhydrotetracycline

Cat.No: T74194

4-epi-Chlortetracycline (hydrochloride)

Cat.No: T36595

Oxytetracycline calcium

Cat.No: T75282

4-Epioxytetracycline

Cat.No: T41353

Prolinomethyltetracycline

Cat.No: T34137

Synonym: PMTC,PM-TC,PM TC

4-Epianhydrochlortetracycline (hydrochloride)

Cat.No: T35950

Isochlortetracycline

Cat.No: T38337

Cat.No: T2469

Synonym: TP-808,TP 808

Target: Others

Cat.No: T3052

Synonym: Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline

Target: Antibacterial

Cat.No: T1569

Synonym: 替加环素,GAR-936

Target: ribosome, Antibacterial, Antibiotic, Autophagy

Minocycline hydrochloride

Cat.No: T1101

Synonym: Minocycline HCl,盐酸米诺环素,美满霉素

Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Dactylocycline A

Cat.No: T23956

Sarecycline free base

Cat.No: T28661

Synonym: WC3035,P 005672,P005672,WC 3035,WC-3035,P-005672

Target: Others

Dactylocyclinone

Cat.No: T31185

Synonym: Sch 34164

Cat.No: T20164

Synonym: Limeciclina,Mucomycin,Tetralisal

Dactylocycline B

Cat.No: T23957

Cat.No: T24867

Synonym: 24-Demethyl-24-ethyltetrin A,Tetramycin A,JA-3789

Dactylocycline E

Cat.No: T31184

Cat.No: T3052L

Synonym: 6-Demethyl-6-deoxytetracycline,GS-2147,GS2147,GS 2147,NSC 51812 (as hydrochloride),Bonomycin

Omadacycline tosylate

Cat.No: T20753

Doxycycline fosfatex

Cat.No: T68614

Dactylocycline D

Cat.No: T23958

Omadacycline HCl

Cat.No: T71266

Cat.No: T71903

Cat.No: T37914

Doxycycline hydrochloride

Cat.No: T1140

Synonym: Doxylin,盐酸多西环素,Vibramycin,Hyclate

Target: MMP, Antibacterial, Antibiotic

Sarecycline hydrochloride

Cat.No: T21394

Synonym: P005672,P-005672,WC-3035,WC 3035,Sarecycline HCl,WC3035,P 005672

Cat.No: T1400L

Synonym: Ledermycin,Bioterciclin,Deteclo,Declostatin,Deganol

Target: Antibacterial

Demeclocycline calcium

Cat.No: T70250

(-)-Viriditoxin

Cat.No: T35437

Previridicatumtoxin

Cat.No: T37006

Cat. No.	Product Name	Target	Signaling Pathways
T0912L	Tetracycline Deschlorobiomycin,Tetracyclinum,Tetracyclin,四环素	Others; ribosome; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Tetracycline (Tetracyclin) 是一种对多种革兰氏阳性和革兰氏阴性细菌有抑制活性的广谱抗生素。
T0912	Tetracycline hydrochloride NCI-c55561,盐酸四环素,Tetracycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Tetracycline hydrochloride (NCI-c55561) 是一种广谱抗生素，抑制多种革兰氏阳性和革兰氏阴性细菌。
T0895	Oxytetracycline 土霉素,Terramycin	ribosome; Endogenous Metabolite; Antibacterial; Antibiotic; HSV	Metabolism; Microbiology/Virology
	Oxytetracycline (Terramycin) 是一种四环素类抗生素。它强力抑制革兰氏阴性和革兰氏阳性细菌。它是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合，具有抗 HSV-1的活性。
T6624	Oxytetracycline Dihydrate 土霉素二水合物,地霉素,Terramycin Dihydrate	Others; Endogenous Metabolite; Antibacterial; Antibiotic; HSV	Metabolism; Microbiology/Virology; Others
	Oxytetracycline Dihydrate (Terramycin Dihydrate) 是一种四环素类抗生素，可抑制革兰氏阴性和革兰氏阳性细菌。它是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合，还具有抗 HSV-1的活性。
T21430	Oxytetracycline Hydrochloride Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin	Antiviral; Endogenous Metabolite; Antibacterial; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Oxytetracycline Hydrochloride (Dalimycin) 是由 Streptomyces rimosus 生产的，一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合，从而阻止肽延伸并抑制蛋白质合成。
T1304	Chlortetracycline hydrochloride Isphamycin,Chlortetracycline HCl,7-Chlorotetracycline hydrochloride,盐酸金霉素	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Chlortetracycline hydrochloride (Isphamycin) 是一种特异性钙离子载体抗生素, 抑制氨酰 tRNA 结合到核糖体。
T1400	Demeclocycline hydrochloride 地美环素,Declomycin,Clortetrin,盐酸地美环素,Detravis,Demeclocycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Demeclocycline hydrochloride (Declomycin) 是四环素类抗生素，可治疗粉刺，莱姆病和支气管炎。
T1687L	Doxycycline (hyclate) Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate	MMP; ribosome; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome
	Doxycycline hyclate (WC2031) 属于四环素类抗生素，是一种广谱的金属蛋白酶 (MMP) 抑制剂，具有口服活性。Doxycycline hyclate 具有抗菌活性和抗肿瘤活性。
T0281	Meclocycline sulfosalicylate salt 磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream	Antibacterial; Antibiotic	Microbiology/Virology
	Meclocycline sulfosalicylate salt (Mecloderm) 是一种具有广谱抗菌活性的四环素抗生素，可预防皮肤细菌感染。
T1687	Doxycycline Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素	MMP; ribosome; Antibacterial; Antibiotic; Parasite	Microbiology/Virology; Proteases/Proteasome
	Doxycycline (Doxiciclina) 属于四环素类抗生素，是一种广谱的金属蛋白酶 (MMP) 抑制剂，具有口服活性。Doxycycline 具有抗菌活性和抗肿瘤活性。
T0518	Methacycline hydrochloride Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Methacycline hydrochloride (Rondomycin) 是四环素抗生素，可抑制细菌蛋白质的合成。它是上皮-间质转化 (EMT) 抑制剂。它在体外可阻断 EMT，体内抑制纤维发生，不会直接影响 TGF-β1 Smad 信号传导。它是抗菌剂，有潜力研究肺纤维化。

天然产物

Cat.No: T0912L

Synonym: Deschlorobiomycin,Tetracyclinum,Tetracyclin,四环素

Target: Others, ribosome, Antibacterial, Antibiotic

Tetracycline hydrochloride

Cat.No: T0912

Synonym: NCI-c55561,盐酸四环素,Tetracycline HCl

Target: ribosome, Antibacterial, Antibiotic

Oxytetracycline

Cat.No: T0895

Synonym: 土霉素,Terramycin

Target: ribosome, Endogenous Metabolite, Antibacterial, Antibiotic, HSV

Oxytetracycline Dihydrate

Cat.No: T6624

Synonym: 土霉素二水合物,地霉素,Terramycin Dihydrate

Target: Others, Endogenous Metabolite, Antibacterial, Antibiotic, HSV

Oxytetracycline Hydrochloride

Cat.No: T21430

Synonym: Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin

Target: Antiviral, Endogenous Metabolite, Antibacterial, HSV

Chlortetracycline hydrochloride

Cat.No: T1304

Synonym: Isphamycin,Chlortetracycline HCl,7-Chlorotetracycline hydrochloride,盐酸金霉素

Target: ribosome, Antibacterial, Antibiotic

Demeclocycline hydrochloride

Cat.No: T1400

Synonym: 地美环素,Declomycin,Clortetrin,盐酸地美环素,Detravis,Demeclocycline HCl

Target: ribosome, Antibacterial, Antibiotic

Doxycycline (hyclate)

Cat.No: T1687L

Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate

Target: MMP, ribosome, Antibacterial, Antibiotic

Meclocycline sulfosalicylate salt

Cat.No: T0281

Synonym: 磺基水杨酸甲氯环素,Meclutin,Mecloderm,甲环素磺基水杨酸盐,Meclan Cream

Target: Antibacterial, Antibiotic

Cat.No: T1687

Synonym: Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素

Target: MMP, ribosome, Antibacterial, Antibiotic, Parasite

Methacycline hydrochloride

Cat.No: T0518

Synonym: Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl

Target: ribosome, Antibacterial, Antibiotic

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