Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1649 |
Tenofovir
替诺福韦,泰诺福韦,PMPA,TDF,GS 1278 |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂,可研究 HIV 和慢性乙型肝炎。 | |||
T28946 |
Tenofovir exalidex
Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157 |
Antiviral | Immunology/Inflammation |
Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物,对野生型和抗逆转录病毒耐药的 HIV 毒株,包括多药核苷/核苷酸类似物耐药病毒,都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性,EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性,无明显毒性。Tenofovir exalidex 对 HBV 也有活性。 | |||
T2409L |
Tenofovir Disoproxil Fumarate
GS-1278 Disoproxil Fumarate,Tenofovir DF,富马酸替诺福韦酯 |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) 是一种核苷酸逆转录酶抑制剂,有潜力研究艾滋病和慢性乙型肝炎。 | |||
T7282 |
Tenofovir alafenamide hemifumarate
GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 HIV 逆转录酶核苷酸抑制剂替诺福韦的口服膦酰胺前药。 | |||
T39043 |
Tenofovir amibufenamide
HS-10234 |
HBV | Microbiology/Virology |
Tenofovir amibufenamide (HS-10234) (HS-10234) 是一种 Tenofovir 前药,是一种具有口服活性的抗病毒化合物。Tenofovir amibufenamide 对乙型肝炎病毒 (HBV)具有抑制作用,可用于慢性乙型肝炎 (CHB) 研究。 | |||
T12814 |
(S)-Tenofovir
(S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF |
Others | Others |
(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体,Tenofovir 是一种核苷酸逆转录酶抑制剂。 | |||
T7111 |
Tenofovir Disoproxil
替诺福韦酯,GS 4331,Bis(POC)-PMPA |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir Disoproxil (GS 4331) 是一种核苷酸逆转录酶抑制剂,用于治疗 HIV 和慢性乙型肝炎。 | |||
T2409 |
Tenofovir alafenamide
替诺福韦艾拉酚胺,替诺福韦,GS-7340 |
HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide (GS-7340) 是一种核苷酸逆转录酶抑制剂和抗逆转录病毒替诺福韦的新型酯类前药。 | |||
T41249 |
Tenofovir alafenamide fumarate
GS-7340 fumarate |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Tenofovir alafenamide fumarate (GS-7340 fumarate) 是一种可口服的 Tenofovir 前体化合物。Tenofovir alafenamide fumarate 具有抗 HIV 活性,可用于预防 HIV 感染。 | |||
T63290 |
(R,1R)-Tenofovir amibufenamide
(R,1R)-HS-10234 |
Antiviral | Immunology/Inflammation |
(R,1R)-Tenofovir amibufenamide ((R,1R)-HS-10234) 可用于 Tenofovir 前药,可口服,具有抗病毒活性。Tynofovir 是一种核苷酸逆转录酶抑制剂。 | |||
T40238 |
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium |
||
Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in vivo pharmacokinetic properties. | |||
T37909 |
Tenofovir diphosphate
|
||
Tenofovir diphosphate (TFV-DP) is a competitive inhibitor of DNA polymerases, specifically targeting dATP, and it serves as a substrate for the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1)[1]. | |||
T40239 |
Tenofovir-C3-O-C15-CF3 ammonium
Tenofovir-C3-O-C15-CF3 ammonium |
||
Tenofovir-C3-O-C15-CF3 (ammonium) demonstrates prolonged half-life values compared to tenofovir in human liver microsomes. It exhibits potent anti-HIV activity in vitro and enhances pharmacokinetic properties in vivo. | |||
T37910 |
Tenofovir diphosphate triethylamine
|
||
Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive inhibitor of DNA polymerases for dATP, functioning as a substrate for HIV type 1 reverse transcriptase (HIV-1 RT)[1]. | |||
T37523 |
Tenofovir diphosphate (sodium salt)
|
||
Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM). It is selective for these enzymes over DNA polymerase α and β, as well as mitochondrial DNA polymerase γ (Kis = 5.2, 81.7, and 59.5 μM, respectively). Tenofovir diphosphate is formed intracellularly through phosphorylation of the prodrugs tenofovir and tenofovir disoproxil by nucleotide kinases. Increased levels of tenof... | |||
T21775 | Tenofovir maleate | ||
Tenofovir maleate (GS 1278 maleate) 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂,用于治疗HIV 和慢性乙型肝炎。 | |||
T1649L |
Tenofovir hydrate
|
||
Tenofovir hydrate (GS 1278 hydrate) 是一种核苷酸逆转录酶抑制剂,用于治疗HIV 和慢性乙型肝炎 (HBV) 。 | |||
T28945 |
Tenofovir disoproxil aspartate
CKD-390,CKD390,CKD 390 |
||
Tenofovir disoproxil aspartate, a nucleotide reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection. | |||
T12127 |
9-Propenyladenine
Mutagenic Impurity of Tenofovir Disoproxil,替诺福韦酯杂质,Tenofovir Impurity 2 |
Others | Others |
9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. | |||
T13457 |
(Z)-9-Propenyladenine
(Z)-替诺福韦酯杂质,(Z)-Mutagenic Impurity of Tenofovir Disoproxil |
Others | Others |
(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. | |||
T72593 |
Antiviral agent 9
|
||
Antiviral agent 9 抗HIV-1的EC50达到皮摩尔浓度(0.006 nM), 与 tenofovir alafenamide fumarate(TAF)相比,选择性指数(SI)高近 300 倍。 |