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5

抑制剂 & 化合物

3

天然产物

11

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T71726 TNFalpha-IN-S10

TNFalpha-IN-S10 is an inhibitor of TNF-α.
T30531L BMS-561392 Formic acid

BMS-561392 Formic acid(611227-74-8 Free base)

MMP Proteases/Proteasome
BMS-561392 Formic acid 是 TACE 的选择性抑制剂,可降低 TNFalpha 水平。
T27967 M199

M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs.
T70703 DK-139

DK-139 is an inhibitor of NF-kappaB-mediated GROalpha expression, suppressing the TNFalpha-induced invasive capability of MDA-MB-231 human breast cancer cells.
T69831 RPR-200765A Mesylayte

RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). At oral doses between 10 and 30 mg/kg/day it reduces the incidence and progression in the rat streptococcal cell wall (SCW) arthritis model when administered in either prophylactic or therapeutic dosing regimens. The compound, which is a mesylate salt and exists as a stable m...

化合物

TNFalpha-IN-S10
Cat.No: T71726
Synonym:
Target:
BMS-561392 Formic acid
Cat.No: T30531L
Synonym: BMS-561392 Formic acid(611227-74-8 Free base)
Target: MMP
M199
Cat.No: T27967
Synonym:
Target:
DK-139
Cat.No: T70703
Synonym:
Target:
RPR-200765A Mesylayte
Cat.No: T69831
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN1373 α-Humulene

Alpha-caryophyllene,ALPHA-律草烯

TNF; NOS; COX Apoptosis; Immunology/Inflammation; Neuroscience
α-Humulene (Alpha-caryophyllene) 是 Tanacetum vulgareL. 精油的主要成分,显示出抗炎作用,IC50=15±2 μg/mL。它抑制 iNOS 和COX-2表达。
T8852 tubuloside B

Apoptosis; Others Apoptosis; Others
Tubuloside B 是可从管花肉苁蓉茎中分离出的一种天然产物,具有抗氧化活性,可抑制TNFα 诱导的细胞凋亡。
T4S0350 Licochalcone B

甘草查尔酮 B,甘草查尔酮B

Beta Amyloid; Others Neuroscience; Others
Licochalcone B 是从Glycyrrhiza inflate 根中提取的。它能够抑制淀粉样蛋白 β 自聚集作用 (IC50=2.16 μM) ,分解预先形成的 Aβ42原纤维,并通过螯合金属离子抑制金属诱导的 Aβ42聚集。

天然产物

α-Humulene
Cat.No: TN1373
Synonym: Alpha-caryophyllene,ALPHA-律草烯
Target: TNF, NOS, COX
tubuloside B
Cat.No: T8852
Synonym:
Target: Apoptosis, Others
Licochalcone B
Cat.No: T4S0350
Synonym: 甘草查尔酮 B,甘草查尔酮B
Target: Beta Amyloid, Others
Cat. No. Product Name Species Expression System
TMPY-01294 TNF alpha Protein, Mouse, Recombinant

TNF-α,Tnfsf1a,TNF-alpha,TNF-a,Tnfa,tumor necrosis factor,TNF...

Mouse E. coli
TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.
TMPY-01697 TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)

Tnfr-1,TNFR80,TNF-R-II,TNF-αR2,tumor necrosis factor recepto...

Mouse HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119.
TMPY-02535 TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)

TNFalpha-R1,TNFAR,TNF-R-I,TNF-R,TNFRp55,FPF,TNF-R55...

Mouse HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.4 kDa and the accession number is P25118.
TMPK-00583 TNF alpha Protein, Ferret, Recombinant (His)

TNF-α,DIF,TNFα,TNF-alpha,TNF α,Cachectin,APC1 protein,TNF,TN...

Ferret E. coli
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1.
TMPK-00119 TNF alpha Protein, Cynomolgus, Recombinant (His)

TNF α,TNFα,APC1 protein,TNF-alpha,TNFA,TNF-α,TNFATNF,TNFSF1A...

Cynomolgus HEK293 Cells
TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337.
TMPK-00120 TNF alpha Protein, Human, Recombinant (His & Avi)

TNFα,APC1 protein,肿瘤坏死因子,TNFSF2,TNF,TNF α,TNF-alpha,TNF-α,TN...

Human HEK293 Cells
TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPK-00121 TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated

TNF,TNF-alpha,TNFATNF,DIF,TNFalpha,TNFα,TNFA,TNF-α,...

Human HEK293 Cells
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375.
TMPY-05187 TNF alpha Protein, Mouse, Recombinant, Biotinylated

Tnfa,TNFSF2,肿瘤坏死因子,Tnfsf1a,TNF-alpha,TNFalpha,DIF,T...

Mouse E. coli
TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804.
TMPY-01696 TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)

TNF-αR2,TNF-R-II,Tnfr2,TNFalpha-R2,TNFBR,tumor necr...

Mouse HEK293 Cells
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.3 kDa and the accession number is P25119.
TMPY-01639 TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)

TNFalpha-R1,TNFRp55,CD120a,TNF-alphaR1,FPF,p55-R,TN...

Mouse HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is P25118.
TMPY-01033 IL-32 Protein, Human, Recombinant (isoform alpha, His)

IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...

Human HEK293 Cells
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...

重组蛋白

TNF alpha Protein, Mouse, Recombinant
Cat.No: TMPY-01294
Species: Mouse
Expression System: E. coli
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01697
Species: Mouse
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02535
Species: Mouse
Expression System: HEK293 Cells
TNF alpha Protein, Ferret, Recombinant (His)
Cat.No: TMPK-00583
Species: Ferret
Expression System: E. coli
TNF alpha Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00119
Species: Cynomolgus
Expression System: HEK293 Cells
TNF alpha Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00120
Species: Human
Expression System: HEK293 Cells
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00121
Species: Human
Expression System: HEK293 Cells
TNF alpha Protein, Mouse, Recombinant, Biotinylated
Cat.No: TMPY-05187
Species: Mouse
Expression System: E. coli
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-01696
Species: Mouse
Expression System: HEK293 Cells
TNFR1/CD120a/TNFRSF1A Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01639
Species: Mouse
Expression System: HEK293 Cells
IL-32 Protein, Human, Recombinant (isoform alpha, His)
Cat.No: TMPY-01033
Species: Human
Expression System: HEK293 Cells
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