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Cat. No. | Product Name | Target | Signaling Pathways |
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T19584L |
TNF-α (31-45), human acetate
TNF-α (31-45), human acetate(144796-71-4 free base) |
Others | Others |
TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。 | |||
TP1537 |
TNF-α (10-36), human
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TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response. | |||
TP1626 |
TNF-α (46-65), human
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Human TNF alpha (46-65) peptide. | |||
T19584 |
TNF-α (31-45), human
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Others | Others |
TNF-α (31-45), human is a peptide of tumor necrosis factor-α. | |||
TP1479 |
TNF-α (10-36), human (TFA) (144796-70-3 free base)
TNF-α (10-36), human (TFA) |
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TNF-α (10-36), human (TFA) is a peptide of human TNF-α. | |||
TP1669 |
TNF-α (46-65), human TFA (144796-72-5 free base)
TNF-α (46-65), human TFA |
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TNF-α (46-65), human (TFA) is a peptide of human TNF-α. | |||
TP1636 |
TNF-α (31-45), human TFA (144796-71-4 free base)
TNF-α (31-45), human TFA |
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TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. | |||
T78434 |
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
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Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA 为基于荧光共振能量转移的多肽底物,通过裂解引起的荧光强度变化来确定其活性。 | |||
T81838 |
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
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Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物,通过其裂解引起的荧光强度变化来评估其活性。 | |||
T9901 |
Adalimumab
|
TNF | Apoptosis |
Adalimumab 是人源的单克隆 IgG1 抗体,靶向肿瘤坏死因子α。 | |||
T10865 |
Cot inhibitor-1
|
TNF; MAPK | Apoptosis; MAPK |
Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生,其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路,特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性,可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。 | |||
T76026 |
TNF-α (31-45), human TFA
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TNF-α (31-45), human TFA 是人肿瘤坏死因子-α 的多肽片段。TNF α 是一种炎性细胞因子,可诱导坏死或凋亡。 | |||
T81606 |
Onercept
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Onercept为重组可溶性人类肿瘤坏死因子-α p55受体,用于Crohn's disease研究。 | |||
T78548 |
3-Hydroxyxanthone
3-Hydroxy-xanthen-9-one |
Integrin | Cytoskeletal Signaling |
3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) 是一种具有抗炎活性的氧杂蒽酮化合物。它能抑制人脐静脉内皮细胞(HUVEC)中NADPH催化的脂质过氧化,并且阻止TNF-α所诱导的ICAM-1表达。 | |||
T36618 |
Rupatadine
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Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6S1256 |
Ruscogenin
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NOS; NF-κB; NOD-like Receptor (NLR) | Immunology/Inflammation; NF-κB |
Ruscogenin 是一种重要甾体皂苷元,提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径,改善脑缺血诱导的血脑屏障功能障碍,具有显著抗血栓、抗炎作用。 | |||
TMA0627 |
Taxiresinol
|
TNF | Apoptosis |
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice. | |||
TN4146 | Glutinol acetate | TNF | Apoptosis |
Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line. | |||
TN5474 |
Bonducellin
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Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac |