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Cat. No.	Product Name	Target	Signaling Pathways
T13168	TLR7 agonist 1	TLR	Immunology/Inflammation
	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T5561	TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist-5d,二盐酸TLR7/8 agonist 1	TLR	Immunology/Inflammation
	TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) 是 toll 样受体TLR7/TLR8的双重激动剂。
T4258	TLR7 agonist 2 TLR7-agonist-1,TLR7-IN-1	TLR	Immunology/Inflammation
	TLR7 agonist 2 (TLR7-IN-1) 是选择性 Toll 样受体 7 激动剂，LEC 值为 0.4 μM。
T8316	1V209 TLR7 agonist T7	TLR	Immunology/Inflammation
	1V209 (TLR7 agonist T7) 是一种 Toll 样受体 7 (TLR7) 激动剂，可与各种多糖缀合，以改善其水溶性，增强功效并保持低毒性，具有抗肿瘤作用。
T71108	TLR7/8 agonist 1
	TLR7/8 agonist 1是一种 toll 样受体 (TLR7)/TLR8的双重激动剂。
T15371	Gardiquimod	TLR; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Gardiquimod 可抑制巨噬细胞和活化的外周血单个核细胞的HIV-1感染。它是一种咪唑喹啉类似物，是一种 TLR7/8 激动剂。
T72253	AXC-715 trihydrochloride T785 trihydrochloride	TLR	Immunology/Inflammation
	AXC-715 trihydrochloride (T785 trihydrochloride) 是一种 TLR7/TLR8 双激动剂，可用于合成抗体佐剂免疫偶联物。偶联物多为程序性死亡配体 1 (PD-L1) 连接到一个或多个佐剂的抗体结构上。
T6964	Resiquimod R848,雷西莫特,S28463	HCV Protease; TLR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂，可诱导细胞因子上调。
T60894	TLR7/8 agonist 4
	TLR7/8 agonist 4 (compound 41) 是具有抗癌活性的，TLR7/8 的有效激动剂。
T78085	Guretolimod hydrochloride DSP-0509 hydrochloride
	Guretolimod hydrochloride为Toll-like receptor7（TLR7）的激动剂。
T79068	TLR7/8 agonist 8
	TLR7/8 agonist 8（compound 24m）是一种高效的TLR7/8双重激动剂，对hTLR7和hTLR8的EC50值分别为27 nM和12 nM。该化合物能增强PD-1/PD-L1阻断剂的抗癌效果。
T74468	MC-Val-Cit-PAB-Amide-TLR7 agonist 4
	MC-Val-Cit-PAB-Amide-TLR7 agonist 4 (example 15) 是一种 HER2-TLR7和 HER2-TLR8免疫激动剂复合物。
T77890	TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride
	TLR7/8 agonist 4hydroxy-PEG6-acid hydrochloride为一种用于抗体药物偶联体(ADC)的药物-连接子偶联物。该化合物为TLR7/8 agonist 4hydroxy-PEG6-acid的盐酸盐形式，由TLR7/8 agonist 4与连接子 Hydroxy-PEG6-acid构成，适用于ADC合成。
T80976	TLR7/8 agonist 4 hydroxy-PEG6-acid
	TLR7/8 agonist 4hydroxy-PEG6-acid 为ADC药物-连接子偶联物（Drug-Linker Conjugates for ADC）。该合成物结合了TLR7/8 agonist 4与连接子hydroxy-PEG6-acid，专门用于ADC合成。
T79749	TLR7 agonist 14
	TLR7 agonist14（compound 17b）作为一种TLR7激动剂，具有高效性，其EC50值为59 nM。在低纳摩尔级别浓度下，TLR7 agonist14能有效激活小鼠巨噬细胞以及hPBMC。
T61260	Ruzotolimod
	Ruzotolimod, an agonist of TLR7, exhibits promising potential for investigating HBV, COVID-19, and SARS-CoV-2 infections （WO2021130195A1）[1].
T70965	GSK-2245035 maleate
	GSK-2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties.
T75213	TLR7 agonist 12
	TLR7 agonist12 (example 20) 是一种针对惰性淋巴系统恶性肿瘤具有广泛抗肿瘤活性的TLR7激动剂及嘌呤核苷类似物。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)来实现。
T40152	AXC-715 hydrochloride
	AXC-715 hydrochloride is a TLR7/TLR8 dual agonist, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants.
T11482	GSK2245035	Others	Others
	GSK2245035 is a highly selective intranasal TLR7 agonist with preferential Type-1 interferon (IFN)-stimulating properties (pEC50s: 9.3 and 6.5 for IFNα and TFNα). It effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood
T61601	TLR7/8 antagonist 2
	TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promising candidate for the treatment and investigation of autoimmune diseases, including lupus erythematosus, which is associated with inappropriate activation of TLR7 and TLR8. Consequently, TLR7/8 antagonist 2 represents a valuable tool for research in the field of autoimmune disea...
T79751	TLR7 agonist 16
	TLR7 agonist16 (compound 16d)为一种高效的TLR7激动剂，具有EC50值为59 nM。在低纳摩尔水平上，它可以有效激活小鼠巨噬细胞和hPBMC。
T82515	E104
	E104（compound 1）为一种高效且选择性的TLR7激动剂，适用于ADC合成，以激发显著的抗癌活性。该化合物能够诱导小鼠巨噬细胞与hPBMC的活化。
T62178	TLR7/8 antagonist 1
	TLR7/8 Antagonist 1 (Compound 16c) 是一种咪唑喹啉衍生物，是一种有效的 TLR7/8 激动剂，对 TLR7 和 TLR8 的 IC50 值分别为 3.91 和 2.19 μM。其中 Toll 样受体 (TLR) 7 和 8 是一种治疗传染病、癌症和自身免疫性疾病的免疫调节药物开发的关键靶点。
T79877	MTvkPABC-P5
	MTvkPABC-P5d，作为TLR7激动剂，属于免疫刺激剂类。该化合物主要应用于合成免疫刺激抗体偶联物(ISAC)。
T61110	UC-1V150
	UC-1V150 is a distinct TLR7 agonist, which activates cellular immune responses and exhibits anti-tumor effects. It also serves as a precursor for the synthesis of ISAC molecules, known as immune-stimulating antibody conjugates [1] [2].
T79750	TLR7 agonist 15
	TLR7 agonist15（compound 16b）作为一种高效的TLR7激动剂，其EC50值为59 nM。在低纳摩尔浓度下，该化合物能够有效诱导小鼠巨噬细胞和hPBMC的激活。
T5499	gardiquimod TFA salt
	Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时，该化合物特异性激活TLR7。
T14035	3M-011	TLR	Immunology/Inflammation
	3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].
T79069	TLR7/8 agonist 9
	TLR7/8 agonist 9 (Compound 25a) 是一种能够增强PD-1/PD-L1阻断疗法抗肿瘤效果的化合物，主要用于癌症免疫疗法研究。它对hTLR7和hTLR8的EC50分别为40 nM和23 nM，显示出其对这两种受体的高亲和力以及潜在的抗肿瘤活性。
T61390	D18
	D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].
T22091	Imiquimod hydrochloride
	Imiquimod hydrochloride (R 837 hydrochloride)是一种免疫反应调节剂，是一种选择性的 toll 样受体 7 (TLR7) 激动剂。Imiquimod hydrochloride 在体内表现出抗病毒和抗肿瘤作用。Imiquimod hydrochloride 可用于外生殖器、肛周疣、癌症和 COVID-19 的研究。
T83895	NCI 126224 NSC 126224
	NCI 126224 是一种 toll-like receptor 4 (TLR4) 的拮抗剂。它在 RAW 264.7 巨噬细胞中，选择性抑制由 TLR4 激动剂 LPS 引起的一氧化氮 (NO) 产生（IC50 = 0.31 µM），而对 TLR7/8 激动剂 R-848、TLR1/2 激动剂 Pam3CSK4 以及 TLR3 激动剂 poly(I:C) 的影响较小；但对于相同细胞中由 TLR2/6 激动剂 FSL-1 引起的 NO 产生，其抑制作用在 0.6 µM 时亦显现。此外，NCI 126224 在 BV-2 微胶质细胞的报告实验中抑制了 LPS 引起的 NF-κB 活性，并在 RAW 264.7 巨噬细胞中降低了 LPS 引起的 IL-1β 和 TNF-α 水平（IC50s = 5.92, 0.42, 和 1.54 µM，分别）。

化合物

TLR7 agonist 1

Cat.No: T13168

Target: TLR

TLR7/8 agonist 1 dihydrochloride

Cat.No: T5561

Synonym: TLR7/8 agonist-5d,二盐酸TLR7/8 agonist 1

Target: TLR

TLR7 agonist 2

Cat.No: T4258

Synonym: TLR7-agonist-1,TLR7-IN-1

Target: TLR

Cat.No: T8316

Synonym: TLR7 agonist T7

Target: TLR

TLR7/8 agonist 1

Cat.No: T71108

Cat.No: T15371

Target: TLR, HIV Protease

AXC-715 trihydrochloride

Cat.No: T72253

Synonym: T785 trihydrochloride

Target: TLR

Cat.No: T6964

Synonym: R848,雷西莫特,S28463

Target: HCV Protease, TLR

TLR7/8 agonist 4

Cat.No: T60894

Guretolimod hydrochloride

Cat.No: T78085

Synonym: DSP-0509 hydrochloride

TLR7/8 agonist 8

Cat.No: T79068

MC-Val-Cit-PAB-Amide-TLR7 agonist 4

Cat.No: T74468

TLR7/8 agonist 4 hydroxy-PEG6-acid hydrochloride

Cat.No: T77890

TLR7/8 agonist 4 hydroxy-PEG6-acid

Cat.No: T80976

TLR7 agonist 14

Cat.No: T79749

Cat.No: T61260

GSK-2245035 maleate

Cat.No: T70965

TLR7 agonist 12

Cat.No: T75213

AXC-715 hydrochloride

Cat.No: T40152

Cat.No: T11482

Target: Others

TLR7/8 antagonist 2

Cat.No: T61601

TLR7 agonist 16

Cat.No: T79751

Cat.No: T82515

TLR7/8 antagonist 1

Cat.No: T62178

Cat.No: T79877

Cat.No: T61110

TLR7 agonist 15

Cat.No: T79750

gardiquimod TFA salt

Cat.No: T5499

Cat.No: T14035

Target: TLR

TLR7/8 agonist 9

Cat.No: T79069

Cat.No: T61390

Imiquimod hydrochloride

Cat.No: T22091

Cat.No: T83895

Synonym: NSC 126224

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