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Search Results for " tg2 "

16

抑制剂 & 化合物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T28137	NC9 TG2 inhibitor NC 9,NC-9 TG2 inhibitor,NC9
	NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).
T69933	VA4 TG2 inhibitor
	VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.
T26494	AA10 TG2 inhibitor AA 10,AA10,AA-10
	AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).
T29086	VA5 TG2 inhibitor VA5,VA-5,VA 5
	VA5 is an transamidase inhibitor by direct binding at the transamidase site. VA5 also inhibits GTP-binding activities. It interaction at the transamidase site locks the protein in the extended/open conformation to disorganize/inactivate the GTP binding/GT
T70413	TG2-IN-3h
	TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitor
T69878	AA9 TG2 inhibitor
	AA9 is a novel transglutaminase (TG2) inhibitor.
T79315	PROTAC TG2 degrader-2	PROTACs	PROTAC
	PROTACTG2 degrader-2（compound 7）是一种针对Transglutaminase 2（TG2）的选择性竞争性降解剂，其Kd值大于100 μM。该化合物能有效抑制卵巢癌细胞的迁移，并降低其TG2表达水平，因此可作为卵巢癌研究的工具。
T79505	PROTAC TG2 degrader-1	PROTACs	PROTAC
	PROTACTG2 degrader-1（化合物 11）是一种靶向组织转谷氨酰胺酶 (TG2) 的VHL基PROTAC，具有68.9 μM的KD值。该化合物通过蛋白酶体途径降低卵巢癌细胞中TG2的水平。
T83855	TG2-179-1
	TG2-179-1是BRCA1相关蛋白1（BAP1）的抑制剂。它在25 µM至1.5 mM的浓度范围内，通过无细胞测定法抑制BAP1的去泛素化活性。TG2-179-1对八种结肠癌细胞系表现出细胞毒性（IC50s = 4.48-7.52 µM）。在体内，TG2-179-1（10和30 mg/kg）能够减少HCT116结肠癌小鼠异种移植模型中的肿瘤体积。
T70412	PNU-145156E free base
	PNU-145156E free base is an angiogenesis inhibitor.
T17289	ZED-1227 ZED-101,TAK-227	Others; Glutaminase	Others; Proteases/Proteasome
	ZED-1227 (TAK-227) 是一种具有口服活性、选择性和高效性的转谷氨酰胺酶 2 (TG2) 抑制剂，具有抗癌活性，能阻塞炎症诱导的 TG2 表达和激活，可用于治疗乳糜泻。
T67865	BJJF078	Glutaminase	Proteases/Proteasome
	BJJF078 是一种氨基哌啶衍生物，是一种有效的重组人和小鼠谷氨酰胺转氨酶 (TG2) 活性的抑制剂，对人和小鼠谷氨酰胺转氨酶的IC50 值分别为 41 和 54 nM。BJJF078 对 TG1 酶有抑制作用，其IC50 为 0.16 μM。 BJJF078 可用于研究多发性硬化症 (MS) 。
T13783	MT-4	Others	Others
	MT-4 可阻断肿瘤细胞和肿瘤niche 表面的TG2/FN 复合体。 MT-4抑制卵巢癌(OC)细胞与腹膜的黏附。
T76951	Zampilimab
	Zampilimab (UCB-7858)，一种转谷氨酰胺酶 2 (TG2) 单克隆抗体，具有肾移植潜在应用。
T26265	TG53 TG-53,TG 53
	TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.
T71477	CP4d inhibitor
	CP4d is a novel reversible tg2 transamidase site-specific inhibitor

化合物

NC9 TG2 inhibitor

Cat.No: T28137

Synonym: NC 9,NC-9 TG2 inhibitor,NC9

VA4 TG2 inhibitor

Cat.No: T69933

AA10 TG2 inhibitor

Cat.No: T26494

Synonym: AA 10,AA10,AA-10

VA5 TG2 inhibitor

Cat.No: T29086

Synonym: VA5,VA-5,VA 5

Cat.No: T70413

AA9 TG2 inhibitor

Cat.No: T69878

PROTAC TG2 degrader-2

Cat.No: T79315

Target: PROTACs

PROTAC TG2 degrader-1

Cat.No: T79505

Target: PROTACs

Cat.No: T83855

PNU-145156E free base

Cat.No: T70412

Cat.No: T17289

Synonym: ZED-101,TAK-227

Target: Others, Glutaminase

Cat.No: T67865

Target: Glutaminase

Cat.No: T13783

Target: Others

Cat.No: T76951

Cat.No: T26265

Synonym: TG-53,TG 53

Cat.No: T71477

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01355	Transglutaminase 2/TGM2 Protein, Human, Recombinant (His) G-α-h,HEL-S-45,TGC,transglutaminase 2,...	Human	Baculovirus Insect Cells
	Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase that also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which...

重组蛋白

Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01355

Species: Human

Expression System: Baculovirus Insect Cells

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