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Search Results for " sulforaphane "

7

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36614	DL-Sulforaphane N-acetyl-L-cysteine
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major ...
T83898	S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine SFN-Cys,D,L-Sulforaphane-L-cysteine
	S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) 是一种异硫氰酸酯衍生物及第一类和第二类组蛋白去乙酰化酶（HDAC）抑制剂和抗癌剂硫代硫酸烯醇醚的活性代谢产物。它通过巯基乙酸途径酶从硫代硫酸烯醇醚经DL-硫代硫酸烯醇醚谷胱甘肽和硫代硫酸烯醇醚半胱氨酸甘肽中间体形成。SFN-Cys (20 µM) 通过创伤愈合和腔室分析实验，分别减少了U87MG和U373 MG胶质母细胞瘤细胞的侵袭和迁移。在45 µM的浓度下，它降低了对紫杉醇耐药的A549肺癌细胞（A549/T）中的α-微管蛋白、βIII-微管蛋白、司他敏1和X连锁抑制剂的凋亡（XIAP）的水平，并减少了细胞密度。使用30 µM浓度的SFN-Cys诱导U87MG和U373 MG细胞凋亡和G2/M期细胞周期停滞。
T29925	Alyssin, (S)-
	Alyssin, (S)-, is an analogue of Sulforaphane that has been shown to have cytotoxic effect on CCRF-SB leukemia cells and lymphoblastoid cells.
T27003	Cheirolin BRN1768925,BRN 1768925,BRN-1768925
	Cheirolin, an antioxidant and sulfonyl analog of sulforaphane, induces phase II enzyme activity and expression.
T27283	Erysolin CCG-38863,CCG 38863,ACM-504847,ACM 504847,CCG38863,ACM504847
	Erysolin, a sulforaphane analog found in cruciferous vegetables, induces phase II enzyme activity and inhibits growth of colon cancer cells.
T29924	Alyssin, (R)-
	Alyssin, (R)-, is an analogue of Sulforaphane that has been shown to have cytotoxic effect on CCRF-SB leukemia cells and lymphoblastoid cells.
T26605	Alyssin
	Alyssin is a sulforaphane homolog and antioxidant. It induces phase II enzymes and increases Nrf2 levels in adenocarcinoma cells. It decreases the metabolism of polycyclic aromatic hydrocarbons, supressing the risk of carcinogenesis in vitro.

化合物

DL-Sulforaphane N-acetyl-L-cysteine

Cat.No: T36614

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine

Cat.No: T83898

Synonym: SFN-Cys,D,L-Sulforaphane-L-cysteine

Cat.No: T29925

Cat.No: T27003

Synonym: BRN1768925,BRN 1768925,BRN-1768925

Cat.No: T27283

Synonym: CCG-38863,CCG 38863,ACM-504847,ACM 504847,CCG38863,ACM504847

Cat.No: T29924

Cat.No: T26605

Cat. No.	Product Name	Target	Signaling Pathways
TQ0207	Sulforaphane 萝卜硫素	Apoptosis; Nrf2; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation
	Sulforaphane 是存在于多种蔬菜中的一种天然异硫氰酸酯。它可以激活Nrf2，并通过 AMPK 依赖性信号传导抑制高糖诱导的胰腺癌。它增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性，具有抗癌和抗炎活性。
T8281	(R)-Sulforaphane L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷	Nrf2	Immunology/Inflammation
	(R)-Sulforaphane (L-Sulforaphane) 是高效的Keap1/Nrf2/ARE 途径诱导剂。与 S-异构体相比，它对大鼠肝脏和肺部的致癌解毒酶系统的诱导能力更强。
T15544	Iberin NSC 321801	Endogenous Metabolite	Metabolism
	Iberin (NSC-321801) 诱导细胞凋亡并抑制细胞存活 (IC50 = 2.3 μM)。 Iberin 是萝卜硫素的类似物。
TQ0212	Glucoraphanin	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Glucoraphanin 是一种硫代葡萄糖苷，存在于十字花科蔬菜中，是 Nrf2 诱导剂 sulforaphane 的前体，sulforaphane 有抗氧化、抗炎、抗癌作用。
T82301	Gluconapin potassium
	Gluconapin potassium为萝卜硫素前体，后者为一抗癌效能显著的异硫氰酸酯。
T27282	Erucin AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056
	Erucin is a sulforaphane analog found in cruciferous vegtables. Erucin is a telomerase inhibitor. It induces phase II enzyme activity, suppresses cellular proliferation in hepatocellular carcinoma cells, prevents 6-OHDA-induced neurodegenration, and inhib

天然产物

Cat.No: TQ0207

Synonym: 萝卜硫素

Target: Apoptosis, Nrf2, HDAC

(R)-Sulforaphane

Cat.No: T8281

Synonym: L-Sulforaphane,(R)-1-异硫氰酰-4-(甲基亚磺酰)丁烷

Target: Nrf2

Cat.No: T15544

Synonym: NSC 321801

Target: Endogenous Metabolite

Cat.No: TQ0212

Target: Antioxidant, Reactive Oxygen Species

Gluconapin potassium

Cat.No: T82301

Cat.No: T27282

Synonym: AR 1G3839,AR-1G3839,CCRIS-9056,CCRIS9056,AR1G3839,CCRIS 9056

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