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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T4459	PK11000	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	PK11000 是一种烷化剂，可通过共价半胱氨酸修饰来稳定野生型和突变型p53的 DNA 结合结构域。
T20029	Buformin hydrochloride NSC528218,NSC-528218,盐酸丁双胍,NSC 528218	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Buformin hydrochloride (NSC-528218) 是一种有效的 AMPK 激活剂，是一种双胍类的口服抗糖尿病药物。Buformin 延缓胃肠道对葡萄糖的吸收，增加胰岛素敏感性和葡萄糖对细胞的吸收，并抑制肝脏对葡萄糖的合成。Buformin 也具有抗癌活性，可用于各种癌症研究。
T8649	TMBIM6 antagonist-1 BAX-inhibitor-1,1-（2-氨基苯基）-3-（3-硝基苯基）-2-丙烯-1-酮,BIA	mTOR	PI3K/Akt/mTOR signaling
	TMBIM6 antagonist-1 (BAX-inhibitor-1) 是有潜力的TMBIM6拮抗剂，能够抑制 TMBIM6 与 mTORC2 结合，抑制 mTORC2 活性，调节TMBIM6 释放 Ca2+。
T31071	CP-654577 UNII-W39547M0FP
	CP-654577 is a selective p185(ErBB2) kinase inhibitor that reduces the level of the activated form of mitogen-activated protein kinase in SKBR3 human breast cancer cells.
T15062	DBCO-NHCO-PEG4-amine	Others	Others
	DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].
T79083	HSP90-IN-22	HSP	Cytoskeletal Signaling; Metabolism
	HSP90-IN-22（Compound 35）作为Hsp90抑制剂，对MCF7乳腺癌细胞的IC50为3.65μM，对SKBr3乳腺癌细胞的IC50为2.71μM，显示出对这些细胞系具有显著的抗增殖活性。
T21749	4-iodo-SAHA
	4-Iodo-SAHA (1k) 是一种具有口服活性的I 类和II 类histone deacetylase (HDAC)抑制剂，对 Skbr3、 HT29、 U937、 JA16 和 HL60细胞的EC50值分别为1.1、0.95、0.12、0.24、0.85和1.3 μM。4-Iodo-SAHA (1k) 可用于癌症的研究。
T36245	SJF 1528
	Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

化合物

PK11000

Cat.No: T4459

Synonym:

Target: DNA Alkylator/Crosslinker

Buformin hydrochloride

Cat.No: T20029

Synonym: NSC528218,NSC-528218,盐酸丁双胍,NSC 528218

Target: AMPK

TMBIM6 antagonist-1

Cat.No: T8649

Synonym: BAX-inhibitor-1,1-（2-氨基苯基）-3-（3-硝基苯基）-2-丙烯-1-酮,BIA

Target: mTOR

CP-654577

Cat.No: T31071

Synonym: UNII-W39547M0FP

Cat. No.	Product Name	Target	Signaling Pathways
T4S0544	Furanodienone 呋喃二烯酮,莪术呋喃二烯酮	Apoptosis; HER	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Furanodienone 是来源于姜黄根茎的一种主要生物活性成分，可诱导细胞凋亡。