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Search Results for " shp1 "

Targets Recommended: Phosphatase

13

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T28410	PHPS1 PHPS-1,PHPS 1	Phosphatase	Metabolism
	PHPS1 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T16350	NSC-87877	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC-87877 是一种Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂，IC50值分别为0.318 μM 和0.355 μM。它还抑制双特异性磷酸酶26。
T4627	SPI--112Me	Others	Others
	SPI--112Me 是 SPI-112 的前药，在无细胞试验中，它优先抑制 Shp2 的 PTPase 活性超过 Shp1 和 PTP1B 20 倍。
T73552	BPDA2
	BPDA2为高选择性竞争性SHP2活性位点抑制剂，SHP2的IC50为92.0 nM, 对SHP1及SHP1B的IC50则分别为33.39 μM与40.71 μM。该化合物降低了有丝分裂促进因子、细胞存活信号以及RTK的表达，并抑制了SHP2介导的信号传导，影响乳腺癌细胞表型。
T6911	NSC-87877 disodium NSC87877	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC-87877 disodium (NSC87877) 是一种有效的Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂，IC50值分别为0.318 μM 和0.355 μM。NSC-87877还抑制双特异性磷酸酶26。
T3962	TPI-1 TPI 1,TPI1	Phosphatase; Glucocorticoid Receptor	Endocrinology/Hormones; Metabolism
	TPI-1 是一种 SHP-1的抑制剂，其 IC50=40 nM。
T39167	GS-493
	GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counterparts, SHP1 and PTP1B, respectively. In addition, GS-493 impedes both cellular motility and growth of cancer cells, portraying promising antitumor effects.
T25953	PHPS1 Sodium PHPS1 Na,PHPS1 Sodium salt
	PHPS1 sodium 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的Ki 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T7541	PTP inhibitor 1 PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮	Phosphatase	Metabolism
	PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂，具有抗血管生成作用。
T7084	2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮	Phosphatase	Metabolism
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
T61701	SHP2-IN-9
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. By inhibiting SHP2-mediated cell signal transduction and impairing cancer cell proliferation, SHP2-IN-9 effectively suppresses the growth of both cervix cancer tumors and glioblastoma in vivo [1].
T38834	LYP-IN-1
	LYP-IN-1 is a powerful LYP inhibitor that demonstrates high potency, selectivity, and specificity, with a Ki of 110 nM and an IC 50 of 0.259 μM. Beyond its primary target, LYP-IN-1 also exhibits selectivity towards a wide range of PTPs, including SHP1 (IC 50 = 5 μM) and SHP2 (IC 50 = 2.5 μM). Additionally, LYP-IN-1 demonstrates remarkable efficacy in T- and mast cells, making it a valuable tool for investigating autoimmune disorders.
T35940	Darinaparsin Dimethylarsinic glutathione,Darinaparsin
	Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,...

化合物

Cat.No: T28410

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

Cat.No: T16350

Target: Apoptosis, Phosphatase

Cat.No: T4627

Target: Others

Cat.No: T73552

NSC-87877 disodium

Cat.No: T6911

Synonym: NSC87877

Target: Apoptosis, Phosphatase

Cat.No: T3962

Synonym: TPI 1,TPI1

Target: Phosphatase, Glucocorticoid Receptor

Cat.No: T39167

Cat.No: T25953

Synonym: PHPS1 Na,PHPS1 Sodium salt

PTP inhibitor 1

Cat.No: T7541

Synonym: PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮

Target: Phosphatase

2-Bromo-4'-hydroxyacetophenone

Cat.No: T7084

Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮

Target: Phosphatase

Cat.No: T61701

Cat.No: T38834

Cat.No: T35940

Synonym: Dimethylarsinic glutathione,Darinaparsin

Cat. No.	Product Name	Target	Signaling Pathways
T79985	Cryptosporioptide A	Phosphatase	Metabolism
	Cryptosporioptide A (Compound 3)是一种从昆虫寄生真菌Cordyceps gracilioides中分离出的色素蛋白酪氨酸磷酸酶抑制剂，针对PTP1B、SHP2、CDC25B、LAR和SHP1等酶展示了抑制作用，其IC50值分别为7.3、5.7、7.6、>50、4.9 μg/mL。

天然产物

Cryptosporioptide A

Cat.No: T79985

Target: Phosphatase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02632	SIRP alpha Protein, Mouse, Recombinant (His) SHP-1,CD172a,SIRP,SHPS-<...	Mouse	HEK293 Cells
	SIRP alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.4 kDa and the accession number is BAA20376.1.
TMPY-02636	SIRP alpha Protein, Mouse, Recombinant (hFc) CD172a,AI835480,SIRP,signal-regulatory protein α,si...	Mouse	HEK293 Cells
	SIRP alpha Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 64.9 kDa and the accession number is BAA20376.1.
TMPY-03296	SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) SH-PTP1,Hcph,70Z-SHP,Ptp1C,protei...	Mouse	Baculovirus Insect Cells
	PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ...
TMPJ-00537	Siglec-3/CD33 Protein, Human, Recombinant (hFc & His) Myeloid Cell Surface Antigen CD33,CD33,Siglec-3,SIGLEC3,gp67...	Human	HEK293 Cells
	CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are c...

重组蛋白

SIRP alpha Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02632

Species: Mouse

Expression System: HEK293 Cells

SIRP alpha Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02636

Species: Mouse

Expression System: HEK293 Cells

SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)

Cat.No: TMPY-03296

Species: Mouse

Expression System: Baculovirus Insect Cells

Siglec-3/CD33 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00537

Species: Human

Expression System: HEK293 Cells

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