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SIRP alpha Protein, Mouse, Recombinant (His)

产品编号 TMPY-02632

别名: SHP-1, CD172a, SIRP, SHPS-1, SIRP α, Ptpns1, signal-regulatory protein α, AI835480, Bit, signal-regulatory protein alpha, P84

SIRP alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.4 kDa and the accession number is BAA20376.1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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SIRP alpha Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		现货
200 μg	￥ 6,750		5日内发货
500 μg	￥ 14,280		5日内发货

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参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized mouse SIRPA-His at 10 μg/ml (100 μl/well) can bind human CD47-Fc , The EC50 of human CD47-Fc is 0.05-0.13 μg/ml.
产品描述	SIRP alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.4 kDa and the accession number is BAA20376.1.

种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	BAA20376.1
别名	SHP-1, CD172a, SIRP, SHPS-1, SIRP α, Ptpns1, signal-regulatory protein α, AI835480, Bit, signal-regulatory protein alpha, P84
蛋白构建	extracellular domain of Mouse SIRPA (BAA20376.1) (Met1-Asn373)
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	39.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Timms JF. et al., 1999, Curr Biol. 9: 927-30. 2. Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9. 3. Liu T. et al., 2005, J Proteome Res. 4: 2070-80. 4. Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.

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Keywords

SIRP alpha Protein, Mouse, Recombinant (His) P-84 SHP-1 CD172a AI-835480 SHP 1 SIRP SHPS-1 SHPS 1 SHP1 SIRP α AI 835480 Ptpns1 SHPS1 signal-regulatory protein α AI835480 Bit signal-regulatory protein alpha P 84 P84 recombinant recombinant-proteins proteins protein

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