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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T34686	Sonoflora 1 SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1
	Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had v
T12075	ML-180 SR1848	Others	Others
	ML-180 (SR1848) 是孤儿核受体肝受体同源物 1 (LRH-1;NR5A2) 的反向激动剂(IC50:3.7 µM)。它不抑制类固醇生成因子 1 (SF-1;NR5A1; IC50>10 µM)。它具有潜在的抗依赖 LRH-1 癌症作用。
T7687	AC 45594 4-庚氧基苯酚,4-Heptyloxyphenol	Others	Others
	AC 45594 (4-Heptyloxyphenol) 是类固醇生成因子 1 (SF-1) 的激动剂 ( IC50 : 50-100 nM)。
T64363	(Iso)-RJW100	Others	Others
	(Iso)-RJW100 是一种有效的肝受体同源物 1 (LRH-1，NR5A2) 和类固醇生成因子-1 (SF-1，NR5A1) 激动剂，pEC50 分别为 6.4 和 7.2。
T38680	RJW100	Others	Others
	RJW100是一种化合物，作为肝受体同源体1(LRH-1, NR5A2)和类固醇生成因子-1(SF-1, NR5A1)的强效激动剂，分别展现出6.6和7.5的pEC50值。此外，RJW100能强力激活miR-200c(miRNA-200c, microRNA-200c)启动子。
T23354	SID 7969543	Others	Others
	Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor
T62757	SID7970631
	SID7970631 是一种异喹啉酮类似物，是一种选择性的、有效的亚微摩尔 SF-1 抑制剂，其 IC50 值为 260 nM。SID7970631 能够用于研究癌症。
T75865	Neuropeptide SF(mouse,rat) TFA
	Neuropeptide SF (mouse,rat) TFA 作为一种高效的 neuropeptide FF receptor 激动剂，对 NPFF1 和 NPFF2 的Ki值分别达到 48.4 nM 和 12.1 nM。该化合物还能够提升异表达的酸感离子通道 3 (ASIC3) 的持续电流幅值。
T79411	hCAXII-IN-7	Carbonic Anhydrase	Metabolism
	hCAXII-IN-7 (compound 6e)为hCA XII抑制剂，且具备脑屏障通透性。此化合物能够诱导786-0、SF-539和HS 578 T细胞系的凋亡。
T73231	RR-RJW100
	RR-RJW100是RJW100的对映异构体之一，后者为核受体肝受体同源物1(LRH-1)和类固醇生成因子1(SF-1)的激动剂。相比于另一对映异构体SS-RJW100，RR-RJW100展现出更强的LRH-1激活能力。此化合物在调节代谢稳态方面具有潜力，因而在糖尿病、肝病以及炎症性肠病等疾病的研究中有所应用。
T61723	SS-RJW100
	SS-RJW100 is an enantiomer of RJW100, known as a racemic agonist that targets two nuclear receptors: liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). In vitro experiments reveal that SS-RJW100 promotes the recruitment of coregulator protein fragments and enhances the interaction with the transcriptional intermediary factor 2 (Tif2) coactivator specifically for LRH-1. Additionally, SS-RJW100 disrupts the allosteric activation networks of LRH-1, displaying suboptimal thermal sta...
T35438	(5E)-7-Oxozeaenol
	(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxozeaenol inhibits proliferation of MCF-7, H460, SF-268, HT-29, and MDA-MB-435 human cancer cells with IC50 values of 4.9, 1.2, 5.6, 4.4, and 5.5 μM, respectively.2 \|1. Fakhouri, L., El-Elimat, T., Hurst, D.P., et al. Isolation, semisynthesis, covalent docking and transforming growt...
T79706	TRK-IN-24	Trk receptor	Tyrosine Kinase/Adaptors
	TRK-IN-24（compound 10g）是一种针对Trk Receptor的抑制剂，它对TRKA、TRKC、TRKAG595R、TRKAG667C和TRKAF589L的抑制作用的IC50值分别达到5.21、4.51、6.77、1.42和6.13 nM。该化合物在BaF3-CD74-NTRK1G595R和BaF3-CD74-NTRK1G667C异种移植模型中显示出明显的抗肿瘤活性。此外，TRK-IN-24 能有效抑制携带SF、GK、xDFG等单点突变的Ba/F3细胞增殖，其IC50范围为1.43至47.56 nM。

化合物

Cat.No: T34686

Synonym: SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1

Cat.No: T12075

Synonym: SR1848

Target: Others

Cat.No: T7687

Synonym: 4-庚氧基苯酚,4-Heptyloxyphenol

Target: Others

Cat.No: T64363

Target: Others

Cat.No: T38680

Target: Others

Cat.No: T23354

Target: Others

Cat.No: T62757

Neuropeptide SF(mouse,rat) TFA

Cat.No: T75865

Cat.No: T79411

Target: Carbonic Anhydrase

Cat.No: T73231

Cat.No: T61723

(5E)-7-Oxozeaenol

Cat.No: T35438

Cat.No: T79706

Target: Trk receptor

Cat. No.	Product Name	Target	Signaling Pathways
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....

天然产物

Cat.No: T38069

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