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13

抑制剂 & 化合物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T83741	S7 TFA Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH
	S7是一种IL-6受体的肽类拮抗剂，能够浓度依赖性地抑制IL-6与IL-6受体的结合。在C-33 A宫颈癌细胞和RPMI-8226 B细胞淋巴细胞中，S7 (50 µM) 能抑制IL-6诱导的VEGF水平增加。在每两天给药一次，剂量为50 mg/kg的条件下，S7能减少IL-6过表达的C-33 A宫颈癌小鼠异种移植模型中的肿瘤体积。当S7与半胱氨酸结合，并连接到包裹多柔比星的脂质纳米粒子(LNPs)表面时，能增强LNPs对胶质瘤的靶向性，并在U251胶质母细胞瘤小鼠异种移植模型中提高生存率。
T6767	TCS7010 Aurora A Inhibitor I	Apoptosis; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	TCS7010 (Aurora A Inhibitor I) 是一种选择性的 Aurora A 抑制剂，IC50值为 3.4 nM。
TP1107L	Mas7 acetate(145854-59-7 free base) Mastoparan 7 acetate	Others	Others
	Mas7 acetate(145854-59-7 free base) (Mastoparan 7 acetate) 是一种乳酪素的结构类似物，是已知的异源三聚体 Gi 蛋白及其下游效应物的激活剂。
T8774	MS7972	Epigenetic Reader Domain	Chromatin/Epigenetic
	MS7972 是一种小分子，能阻断人 p53 和 CREB 结合。它在50 μM 的时候几乎可以完全阻断 BRD 的相互作用。
T71939	PS77
	PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.
T11574	HS79	Others	Others
	HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids (IC50: 1.57 μM).
T78715	MS78
	MS78为一种乙酰化靶向嵌合体(AceTAC)，其功能是招募组蛋白乙酰转移酶p300/CBP以乙酰化p53肿瘤抑制蛋白的p53Y220C突变体。通过该作用，MS78能够上调TRAIL凋亡基因，同时下调DNA损伤反应信号通路。此化合物结构包含CBP/p300结合物、p53Y220C结合物及linker。
T13471	(±)-WS75624B	Others	Others
	(±)-WS75624B 是一种有效的内皮素转化酶 (ECE) 抑制剂（IC50 ： 0.03 μg/mL），是一种5 -羟色胺受体激动剂。
T71210	S7958
	S7958 is a is a TAS2R8 antagonist. It was found to be non-mutagenic in vitro.
T83492	[His7] Corazonin
	[His7] Corazonin是一种诱导迁征蝗虫角质层与表皮层着色加深的神经激素。
TP1107	Mas7 Mastoparan 7
	Amphiphilic peptide Mas7, a structural analogue of mastoparan is a known activator of heterotrimeric Gi-proteins and its downstream effectors.
T79326	MRS7925	5-HT Receptor	GPCR/G Protein; Neuroscience
	MRS7925（Compound 43）为高选择性5-HT2BR拮抗剂，其Ki值为17 nM。该化合物主要用于纤维化研究领域。
T6664	SecinH3	Apoptosis	Apoptosis
	SecinH3 是cytohesins 的拮抗剂，是选择性细胞粘附素抑制剂。对于hCyh1、hCyh2、mCyh3、hCyh3、果蝇和yGea2-S7的IC50值分别为 5.4 μM、2.4 μM、5.4 μM、5.6 μM、5.6 μM 和 65 μM。

化合物

Cat.No: T83741

Synonym: Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH

Cat.No: T6767

Synonym: Aurora A Inhibitor I

Target: Apoptosis, Aurora Kinase

Mas7 acetate(145854-59-7 free base)

Cat.No: TP1107L

Synonym: Mastoparan 7 acetate

Target: Others

Cat.No: T8774

Target: Epigenetic Reader Domain

Cat.No: T71939

Cat.No: T11574

Target: Others

Cat.No: T78715

Cat.No: T13471

Target: Others

Cat.No: T71210

[His7] Corazonin

Cat.No: T83492

Cat.No: TP1107

Synonym: Mastoparan 7

Cat.No: T79326

Target: 5-HT Receptor

Cat.No: T6664

Target: Apoptosis

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00562	30S ribosomal protein S7 Protein, E. coli, Recombinant (His) 30S ribosomal protein S7,rpsG,Small ribosomal subun...	E. coli	E. coli
	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, where it has been shown to contact mRNA. Has been shown to contact tRNA in both the P and E sites; it probably blocks exit of the E site tRNA.; Protein S7 is also a translational repressor protein; it regulates the expression of the str operon members to different degrees by binding to its mRNA...
TMPY-05271	CD20 Protein, Human, Recombinant (TrxA), Biotinylated MS4A2,CD20,LEU-16,CVID5,membrane-spanning 4-domains, subfami...	Human	E. coli
	CD20 Protein, Human, Recombinant (TrxA), Biotinylated is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.
TMPJ-01046	RPS7 Protein, Human, Recombinant (His) RPS7,40S ribosomal protein S7	Human	E. coli
	40S ribosomal protein S7(RPS7) belongs to the S7E family of ribosomal proteins. It is phosphorylated by NEK6 during post-translational modification. RPS7 is located in the cytoplasm, binds IPO9 with high affinity. it also can interacts with NEK6. As is required for rRNA maturation and typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. The unnormal expression of RPS7 may cause Diamond-Blackfan anemia 8.
TMPK-00183	CD20 Protein, Human, Recombinant (His & Avi) MS4A2,Ly-44,LEU-16,MS4A1,Bp35,CD20 receptor,CVID5,MS4A-1,B1,...	Human	E. coli
	B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. CD20...
TMPY-04615	CD20 Protein, Human, Recombinant (TrxA) MS4A2,CD20,CVID5,S7,Bp35,membrane-spanning 4-domain...	Human	E. coli
	CD20 Protein, Human, Recombinant (TrxA) is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.
TMPY-02819	CD20 Protein, Human, Recombinant (aa 213-297, His) Bp35,MS4A2,LEU-16,CVID5,MS4A1,membrane-spanning 4-domains, s...	Human	HEK293 Cells
	CD20 Protein, Human, Recombinant (aa 213-297, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.1 kDa and the accession number is A0A024R507.
TMPJ-00692	GAS7 Protein, Human, Recombinant (His) GAS-7,GAS7,Growth Arrest-Specific Protein 7,KIAA039...	Human	E. coli
	Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebullum impedes neurite outgrowth. The hyper-expression of GAS7 may play an major role in the initiation and development...
TMPH-00868	ADAMTS7 Protein, Human, Recombinant (His & SUMO) ADAM-TS7,ADAMTS-7,ADAM-TS 7,A disintegrin and metal...	Human	E. coli
	Metalloprotease that may play a role in the degradation of COMP. ADAMTS7 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.1 kDa and the accession number is Q9UKP4.
TMPH-00869	ADAMTS7 Protein, Human, Recombinant (His) ADAM-TS7,ADAM-TS 7,COMPase,ADAMTS-7,A disintegrin a...	Human	P. pastoris (Yeast)
	Metalloprotease that may play a role in the degradation of COMP. ADAMTS7 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.1 kDa and the accession number is Q9UKP4.
TMPJ-00022	LGALS7 Protein, Human, Recombinant Galectin-7,Gal-7,LGALS7,PI7,PIG1,LGALS7B,p...	Human	E. coli
	The Galectin family of proteins, with specificity for Nacetyllactosamine containing glycoproteins, consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs).They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. Although they are localized primarily in the cytoplasm and lack a classical signal peptide; they can be secreted ...
TMPY-03599	RPRD1B Protein, Human, Recombinant (His) C20orf77,regulation of nuclear pre-mRNA domain containing 1B...	Human	HEK293 Cells
	RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phosphorylated RNAP II at target gene promoters. RNA polymerase II C-terminal domain (CTD) phosphorylation is important for various transcription-related processes. RPRD1B is a transcriptional regulator that enhances expression of CCND1. It also enhances the transcription of a number of...

重组蛋白

30S ribosomal protein S7 Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00562

Species: E. coli

Expression System: E. coli

CD20 Protein, Human, Recombinant (TrxA), Biotinylated

Cat.No: TMPY-05271

Species: Human

Expression System: E. coli

RPS7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01046

Species: Human

Expression System: E. coli

CD20 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00183

Species: Human

Expression System: E. coli

CD20 Protein, Human, Recombinant (TrxA)

Cat.No: TMPY-04615

Species: Human

Expression System: E. coli

CD20 Protein, Human, Recombinant (aa 213-297, His)

Cat.No: TMPY-02819

Species: Human

Expression System: HEK293 Cells

GAS7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00692

Species: Human

Expression System: E. coli

ADAMTS7 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00868

Species: Human

Expression System: E. coli

ADAMTS7 Protein, Human, Recombinant (His)

Cat.No: TMPH-00869

Species: Human

Expression System: P. pastoris (Yeast)

LGALS7 Protein, Human, Recombinant

Cat.No: TMPJ-00022

Species: Human

Expression System: E. coli

RPRD1B Protein, Human, Recombinant (His)

Cat.No: TMPY-03599

Species: Human

Expression System: HEK293 Cells

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