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Cat. No.	Product Name	Target	Signaling Pathways
T2087	AF-353 Ro-4	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	AF-353 (Ro-4) 是一种选择性、可口服的 P2X3/P2X2/3 受体拮抗剂，抑制人和大鼠 P2X3 的 pIC50值为 8.0，抑制人 P2X2/3 的 pIC50值为 7.3。
T5412	RO4987655 CH4987655,RG7167	MEK	MAPK
	RO4987655 (RG7167) 是一种具有口服活性和高选择性的 MEK 抑制剂，抑制MEK1/MEK2，IC50为 5.2 nM。
T22416	RO495 CS-2667	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	RO495 (CS-2667) 是一种有效的非受体酪氨酸蛋白激酶2抑制剂。
T6274	RO4929097 RG-4733	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	RO4929097 (RG-4733) 是 γ secretase 抑制剂，IC50=4 nM，能够抑制细胞内 Aβ40 (EC50:14 nM) 的产生和 Notch (EC50:5 nM) 活性。
T83496	[D-Pro4,D-Trp7,9,10] Substance P (4-11)
	[D-Pro4,D-Trp7,9,10] Substance P (4-11) 是一种tachykinin拮抗剂，具有高效性。
T28601	RO4988546 RO-4988546,RO 4988546
	RO4988546 is a potent negative allosteric modulator of mGlu₂/₃.
T76406	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)
	[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) 为高效的神经激肽 NK1 拮抗剂，能够有效抑制金蛋白 P 物质 (GPSP) 与 P 物质 (SP) 的活性。
T68623	RO4583298
	RO4583298 is a highly potent dual NK1/NK3 receptor antagonist with in vivo activity.
T83495	[D-Pro4,D-Trp7,9] Substance P (4-11)
	[D-Pro4,D-Trp7,9]Substance P(4-11)为高效Substance P 拮抗剂，可降低血浆醛固酮(ALDO)浓度。
T28600	Ro4491533 Ro 4491533,Ro-4491533
	Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).
T68459	RO4927350
	RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback inc...