Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0684 |
Ribavirin
Tribavirin,ICN-1229,NSC-163039,利巴韦林,RTCA |
Dehydrogenase; HCV Protease; DNA/RNA Synthesis; Antibiotic; AChR; RSV | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ribavirin (Tribavirin) 是一种合成的呋喃核苷类似物,具有抗丙型肝炎病毒和其他 RNA 病毒的活性。 | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
||
Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... | |||
T23938 |
D4-Ribavirin
D4Ribavirin,D4 Ribavirin |
||
D4-Ribavirin is isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregular. | |||
T25702 |
Levovirin
ICN 17261,L-Ribavirin,ICN-17261,ICN17261 |
||
Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin. Levovirin has similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia. | |||
T37877 |
Ribavirin 5'-monophosphate (lithium salt)
|
||
Ribavirin 5'-monophosphate (lithium salt)对 IMP 脱氢酶(将 IMP 转化为 XMP)具体直接抑制作用 | |||
TNU0339 |
Ribavirin carboxylic acid
|
||
Nucleoside Derivatives - Other modified nucleosides; Drugs and Inhibitors; Ribavirin related compound A; metabolite of Ribavirin | |||
T16993 |
Taribavirin
|
Others | Others |
Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of he | |||
T16992 |
Taribavirin hydrochloride
|
Others | Others |
Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor. Taribavirin hydrochloride is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells and | |||
T27586 |
IDX184
IDX-184,IDX 184 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
IDX184 是一种有效的,具有口服活性的靶向 HCV 聚合酶抑制剂和核苷聚合酶抑制剂。IDX184 有效抑制 HCV 聚合酶 (IC50=0.31 μM,Ki=52.3 nM)。 IDX184是一种肝脏靶向核苷酸前药,具有抗HCV活性,可抑制HCV NS5B聚合酶,可与聚乙二醇化干扰素-α2a 和利巴韦林联合用于初治慢性丙型肝炎。 | |||
T70846 |
Deleobuvir sodium
|
||
Deleobuvir sodium is the salt form of Deleobuvir, also known as BI207127, a non-nucleoside hepatitis C virus NS5B polymerase inhibitor for the treatment of hepatitis C. Deleobuvir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including faldaprevir. Deleobuvir showed that a triple combination of deleobuvir, faldaprevir, and ribavirin performed well in HCV genotype 1b patients. Efficacy fell b... | |||
T61291 | RSV/IAV-IN-2 | ||
RSV/IAV-IN-2 (compound 14c) 是一种有效的 RSV/IAV 双重抑制剂。RSV/IAV-IN-2 的细胞毒性低于临床药物利巴韦林。RSV/IAV-IN-2 具有研究 RSV 和/或 IAV 感染的潜力。 | |||
T79219 |
RSV L-protein-IN-3
|
RSV | Microbiology/Virology |
RSVL-protein-IN-3为一野生型RSV聚合酶抑制剂,具IC50值10.4 μM及EC50值2.1 μM(RSV)。相较之下,RSV/IAV-IN-2之细胞毒性显著低于临床活性分子Ribavirin。 | |||
T61343 |
RSV/IAV-IN-1
|
||
RSV/IAV-IN-1 (compound 14e) 是一种有效的 RSV/IAV 双重抑制剂。RSV/IAV-IN-1 的细胞毒性低于临床药物利巴韦林。RSV/IAV-IN-1 具有研究 RSV 和/或 IAV 感染的潜力。 | |||
T14493 |
Balapiravir
R1626,Ro 4588161 |
Others | Others |
Balapiravir (R1626, Ro 4588161) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479). IC50 Value: Target: HCV Balapiravir was discontinued for safety reasons in 28-36% of patients (m |