首页工具

登录

搜索结果

Search Results for " rock-in-1 "

16

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T13419	ROCK-IN-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-1 是一种高效的 ROCK 抑制剂，对 ROCK2 介导的信号传导有抑制作用，IC50 值为 1.2 nM。ROCK-IN-1 可用于研究神经系统疾病和炎症相关疾病。
TQ0110	ROCK-IN-2 TC-S 7001,Azaindole 1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-2 (Azaindole 1) 是一种选择性，ATP-竞争型的ROCK 抑制剂，对ROCK-1和ROCK-2的IC50值分别为 0.6 和 1.1 nM。
T24723	ROCK-IN-D1 ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1
	ROCK-IN-D1 is an effective and selective inhibitor of ROCK.
T79905	Akt/ROCK-IN-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Akt/ROCK-IN-1 (B12) 是Akt和ROCK的双重抑制剂，IC50值分别为0.023 nM和1.47 nM。该化合物对神经母细胞瘤表现出抗肿瘤活性。
T12721	Rho-Kinase-IN-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Rho-Kinase-IN-1 是一种 ROCK 抑制剂，对 ROCK1 和 ROCK2 的 Kis 分别为 30.5 nM 和 3.9 nM。 Rho-Kinase-IN-1 可用于细胞过度增殖、重塑、水肿和炎症疾病的研究。
T9652	SB-747651A Dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	SB-747651A dihydrochloride是一种与ATP竞争性相互作用的抑制剂，特别针对丝裂原和应激激活激酶1 (MSK1)，IC50值为11 nM。此化合物还能抑制PRK2、RSK1、p70S6K和ROCK-II等酶的活性。因其对上述激酶的抑制作用，SB-747651A dihydrochloride在炎症研究中显示出潜力。
T79080	ROCK-IN-7	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-7（compound 9）作为ROCK激酶抑制剂，主要应用于眼部疾病（包括青光眼及视网膜疾病）的研究领域。
T79809	ROCK-IN-8	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-8 (Example 4) 是ROCK抑制剂，IC50值不足100 nM，并显示出抗炎活性，适用于呼吸系统和胃肠道疾病的研究。
T79833	ROCK-IN-9	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-9（Compound T345）为ROCK抑制剂。该化合物在HepG2细胞中表现出IC50为40.8 μM的细胞毒性。在小鼠模型中，ROCK-IN-9展现了良好的药代动力学特性，即使在低剂量下也能获得较高的体内暴露水平及口服生物利用度。
T79832	ROCK2-IN-6	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK2-IN-6 (Comp A) 是一種选择性针对ROCK2的抑制剂，适用于研究ROCK介导的病症、自身免疫性疾病以及炎症。
T78205	ROCK2-IN-6 hydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。
T79077	ROCK-IN-6	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-6为一有效的ROCK2抑制剂，其IC50值为2.19 nM。该化合物具备用于研究青光眼及视网膜疾病的潜力。
T61497	Rho-Kinase-IN-2
	Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC50) of 3 nM. This compound is of potential interest for further investigations in the field of Huntington's disease research [1].
T69429	Y27632 HCl hydrate
	Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord...
T35659	3'-Dephosphocoenzyme A
	3'-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A from pantothenic acid .1 It is phosphorylated by CoA synthase in humans to form CoA. 3'-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.2,3 References1. Leonardi, R., Zhang, Y.M., Rock, C.O., et al. Coenzyme A: Back in action. Prog. Lipid Res. 44(2-3), 125-153 (2005).2. Huang, F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcripti...
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

化合物

Cat.No: T13419

Target: ROCK

Cat.No: TQ0110

Synonym: TC-S 7001,Azaindole 1

Target: ROCK

Cat.No: T24723

Synonym: ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1

Akt/ROCK-IN-1

Cat.No: T79905

Target: ROCK

Rho-Kinase-IN-1

Cat.No: T12721

Target: ROCK

SB-747651A Dihydrochloride

Cat.No: T9652

Target: ROCK

Cat.No: T79080

Target: ROCK

Cat.No: T79809

Target: ROCK

Cat.No: T79833

Target: ROCK

Cat.No: T79832

Target: ROCK

ROCK2-IN-6 hydrochloride

Cat.No: T78205

Target: ROCK

Cat.No: T79077

Target: ROCK

Rho-Kinase-IN-2

Cat.No: T61497

Y27632 HCl hydrate

Cat.No: T69429

3'-Dephosphocoenzyme A

Cat.No: T35659

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

Cat. No.	Product Name	Target	Signaling Pathways
T4S1962	beta-Asarone β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB; JNK	MAPK; NF-κB
	beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分，具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障，能够预防帕金森病。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。

天然产物

Cat.No: T4S1962

Synonym: β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin

Target: NF-κB, JNK

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼