16
2
Cat. No. | Product Name | Target | Signaling Pathways |
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T13419 |
ROCK-IN-1
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK-IN-1 是一种高效的 ROCK 抑制剂,对 ROCK2 介导的信号传导有抑制作用,IC50 值为 1.2 nM。ROCK-IN-1 可用于研究神经系统疾病和炎症相关疾病。 | |||
TQ0110 |
ROCK-IN-2
TC-S 7001,Azaindole 1 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK-IN-2 (Azaindole 1) 是一种选择性,ATP-竞争型的ROCK 抑制剂,对ROCK-1和ROCK-2的IC50值分别为 0.6 和 1.1 nM。 | |||
T24723 |
ROCK-IN-D1
ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1 |
||
ROCK-IN-D1 is an effective and selective inhibitor of ROCK. | |||
T79905 |
Akt/ROCK-IN-1
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Akt/ROCK-IN-1 (B12) 是Akt和ROCK的双重抑制剂,IC50值分别为0.023 nM和1.47 nM。该化合物对神经母细胞瘤表现出抗肿瘤活性。 | |||
T12721 |
Rho-Kinase-IN-1
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Rho-Kinase-IN-1 是一种 ROCK 抑制剂,对 ROCK1 和 ROCK2 的 Kis 分别为 30.5 nM 和 3.9 nM。 Rho-Kinase-IN-1 可用于细胞过度增殖、重塑、水肿和炎症疾病的研究。 | |||
T9652 |
SB-747651A Dihydrochloride
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
SB-747651A dihydrochloride是一种与ATP竞争性相互作用的抑制剂,特别针对丝裂原和应激激活激酶1 (MSK1),IC50值为11 nM。此化合物还能抑制PRK2、RSK1、p70S6K和ROCK-II等酶的活性。因其对上述激酶的抑制作用,SB-747651A dihydrochloride在炎症研究中显示出潜力。 | |||
T79080 |
ROCK-IN-7
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK-IN-7(compound 9)作为ROCK激酶抑制剂,主要应用于眼部疾病(包括青光眼及视网膜疾病)的研究领域。 | |||
T79809 |
ROCK-IN-8
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK-IN-8 (Example 4) 是ROCK抑制剂,IC50值不足100 nM,并显示出抗炎活性,适用于呼吸系统和胃肠道疾病的研究。 | |||
T79833 |
ROCK-IN-9
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK-IN-9(Compound T345)为ROCK抑制剂。该化合物在HepG2细胞中表现出IC50为40.8 μM的细胞毒性。在小鼠模型中,ROCK-IN-9展现了良好的药代动力学特性,即使在低剂量下也能获得较高的体内暴露水平及口服生物利用度。 | |||
T79832 |
ROCK2-IN-6
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK2-IN-6 (Comp A) 是一種选择性针对ROCK2的抑制剂,适用于研究ROCK介导的病症、自身免疫性疾病以及炎症。 | |||
T78205 |
ROCK2-IN-6 hydrochloride
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂,适用于研究ROCK介导的疾病、自身免疫性病症与炎症。 | |||
T79077 | ROCK-IN-6 | ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK-IN-6为一有效的ROCK2抑制剂,其IC50值为2.19 nM。该化合物具备用于研究青光眼及视网膜疾病的潜力。 | |||
T61497 |
Rho-Kinase-IN-2
|
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Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC50) of 3 nM. This compound is of potential interest for further investigations in the field of Huntington's disease research [1]. | |||
T69429 | Y27632 HCl hydrate | ||
Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord... | |||
T35659 |
3'-Dephosphocoenzyme A
|
||
3'-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A from pantothenic acid .1 It is phosphorylated by CoA synthase in humans to form CoA. 3'-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.2,3 References1. Leonardi, R., Zhang, Y.M., Rock, C.O., et al. Coenzyme A: Back in action. Prog. Lipid Res. 44(2-3), 125-153 (2005).2. Huang, F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcripti... | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S1962 |
beta-Asarone
β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin |
NF-κB; JNK | MAPK; NF-κB |
beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分,具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障,能够预防帕金森病。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 |