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60

抑制剂 & 化合物

2

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Cat. No.	Product Name	Target	Signaling Pathways
T6966	RGD RGD (Arg-Gly-Asp) Peptides,Arg-Gly-Asp,RGD Peptides	Integrin	Cytoskeletal Signaling
	RGD (RGD (Arg-Gly-Asp) Peptides) 是一种细胞粘附基序，可以模拟细胞粘附蛋白并与整合素结合。
T7570	RGD peptide (GRGDNP) RGD peptide GRGDNP(2TFA),H-甘氨酰-精氨酰-甘氨酰-天冬氨酰-天冬酰胺酰-脯氨酸-OH,RGD peptide GRGDNP	Apoptosis; Integrin	Apoptosis; Cytoskeletal Signaling
	RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) 是一种整合素-配体相互作用的抑制剂，通过激活构象变化促进细胞凋亡，从而增强 caspase-3的活化，在细胞黏附、迁移、生长和分化中发挥重要作用。
T4613	Arg-Gly-Asp TFA (99896-85-2(free base)) RGD Trifluoroacetate,RGD	Integrin	Cytoskeletal Signaling
	Arg-Gly-Asp TFA (99896-85-2(free base)) (RGD Trifluoroacetate) 是一种三肽，可有效触发细胞粘附、定位某些细胞系并引发特定的细胞反应；与整合素结合。
TP1311	RGD peptide (GRGDNP) (TFA) (114681-65-1 free base) RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) (TFA) promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing.
TP1343	RGD Trifluoroacetate
	RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; RGD Trifluoroacetate binds to integrins.RGD Trifluoroacetate is the most effective and most often employed pept
T76378	RGD-4C
	RGD-4C（ACDCRGDCFC）是一种携带Arg-Gly-Asp（RGD）序列的肽，具备与αv整合素结合的能力，用于模拟细胞外基质蛋白的整合素识别特性。作为αv整合素的配体，它能够与生物活性分子进行偶联，进而在动物模型中展现出抗肿瘤活性。
T76007	RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) TFA 作为整合素-配体之间相互作用的竞争性抑制剂，阻碍α5β1与细胞外基质(ECM)的结合，并通过激活增强pro-caspase-3的自我加工和构象变化来促进细胞凋亡。该化合物在细胞粘附、迁移、生长和分化等过程中扮演着关键角色。
T81283	RGD-targeted Proapoptotic Peptide
	RGD-targeted Proapoptotic Peptide为一肽类化合物，其C端RGD-4C肽段（ACDCRGDCFC）能够特异性地与肿瘤新生血管的整合素结合位点优先结合。
T7566	GRGDSPK EMD 56574	Others	Others
	GRGDSPK (EMD 56574) 是一种包含精氨酸-甘氨酸-天冬氨酸 (RGD) 的多肽，也是一种竞争性且可逆的抑制肽，可抑制整联蛋白-纤连蛋白结合，可用于整联蛋白在骨形成和吸收中作用的研究。
T7566L	GRGDSPK 2TFA(111119-28-9(free base)) EMD 56574	Others	Others
	GRGDSPK 2TFA(111119-28-9(free base)) (EMD 56574) 是一种抑制肽，用于 RGD 介导的整合素和细胞外基质分子之间的粘附。
TP1530L	YRGDS Fibronectin Fragment acetate YRGDS Fibronectin Fragment acetate(134282-68-1 free base)	Others	Others
	YRGDS Fibronectin Fragment acetate (YRGDS Fibronectin Fragment acetate (134282-68-1 free base))(134282-68-1 free base) 是一种纤连蛋白片段乙酸酯，是一种粘附肽，对凝血酶刺激的血小板具有很强的结合亲和力。它是由序列组成的 RGD。
TP1290	GRGDSP acetate(91037-75-1 free base) GRGDSP TFA	Integrin	Cytoskeletal Signaling
	GRGDSP acetate(91037-75-1 free base) 是一种合成的线性 RGD 肽，是一种整合素抑制剂。
TP1696L	CGGRGD acetate(1260223-44-6 free base)	Others	Others
	CGGRGD acetate(1260223-44-6 free base) 是一种以半胱氨酸为 n 端的 RGD 衍生物。 CGGRGD 采用固相多肽合成技术合成，在PCL 纤维表面添加氨基2-氰基苯并噻唑(2-cyanobenzothiazole)(2-cyanobenzothiazole (CBT))进行氨化。
TP2484L	Cyclo(-RGDyC)acetate	Others	Others
	Cyclo(-RGDyC)acetate 是一种整合素 avb3 亲和多肽，一种环状 RGDyc 序列。
TP2483L	Cyclo(-RGDfC)acetate Cyclo(-RGDfC)acetate(862772-11-0 free base)	Others	Others
	Cyclo(-RGDfC)acetate 是一种整合素 avb3 亲和多肽，一种环状 RGDfc 序列。
T6813	Cyclo(RGDyK) trifluoroacetate Cyclo(RGDyK)	Integrin	Cytoskeletal Signaling
	Cyclo(RGDyK) trifluoroacetate 是一种选择性αVβ3整联蛋白抑制剂，IC50为 20 nM。
TP1759L	GRGDSPC acetate GRGDSPC,GRGDSPC acetate(91575-26-7 free base)	Others	Others
	GRGDSPC acetate (GRGDSPC acetate (91575-26-7 free base)) 是硫醇化细胞粘附的 7 个氨基酸肽。
T6812	Cyclo(-RGDfK) Cyclo (-RGDfK)	Integrin	Cytoskeletal Signaling
	Cyclo(-RGDfK) (Cyclo (-RGDfK)) 是一种选择性整合素αvβ3的有效抑制剂，IC50值为 0.94 nM。它通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。
T7566L1	GRGDSPK acetate GRGDSPK acetate(111119-28-9 Free base)	Beta Amyloid	Neuroscience
	GRGDSPK acetate 显示出对整合素-纤连蛋白结合的抑制活性，可用于研究整合素在骨形成和吸收中的作用。
TP1204	iRGD peptide c(CRGDKGPDC)	Integrin	Cytoskeletal Signaling
	iRGD peptide (c(CRGDKGPDC)) 是由 9 个氨基酸组成的环肽，具有靶向肿瘤和肿瘤渗透的作用。
T6812L	Cyclo(-RGDfK) TFA	Integrin	Cytoskeletal Signaling
	Cyclo(-RGDfK) TFA 是一种选择性整合素αvβ3的有效抑制剂，其IC50值为 0.94 nM。它通过与细胞表面的 αvβ3 整合素结合，特异性靶向肿瘤微血管和癌细胞。
TP1421	GRGDSP
	Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide.
T75765	GRGDSPK TFA
	GRGDSPK TFA (EMD 56574 TFA) 是一种含有精氨酸-甘氨酸-天冬氨酸 (RGD) 序列的多肽。作为竞争性且可逆的抑制剂，它能够抑制整联蛋白与纤连蛋白的结合，用于探究整联蛋白在骨形成及吸收过程中的功能。
TP1530	YRGDS Fibronectin Fragment
	This is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets. It is RGD consisting of sequence.
TP1696	CGGRGD
	CGGRGD is a RGD derivative with cysteine as the n-terminal. CGGRGD was synthesized by solid phase peptide synthesis technology, and amino2-cyanobenzothiazole (2-cyanobenzothiazole) (2-cyanobenzothiazole (CBT) was added on the surface of PCL fiber for ammo
T80214	cRGDfK-thioacetyl ester	Integrin	Cytoskeletal Signaling
	cRGDfK-thioacetyl ester 为具选择性亲和力于整合素（integrins）之生物活性多肽。可应用于修饰NIR荧光探针，实现癌症靶向成像。
T82641	Cyclo(RGDyC)
	Cyclo(RGDyC) 是环状五肽，有抗血管生成作用。可结合脂质体递送系统，用于研究眼部新生血管疾病及癌症。
T81284	RGDT
	RGDT是一种合成肽，用于癌症研究。
TP1759	GRGDSPC
	GRGDSPC, a 7-amino acid peptide, is a thiolated cell adhesion peptide.This peptide is an ideal novel targeted non-viral gene delivery vector, which was easy to be synthesized, high efficient and low cytotoxicity.
T77996	iRGD peptide 1 TFA
	iRGD peptide 1 TFA为原型肿瘤组织特异性穿透肽，能深入血管外肿瘤组织传递活性分子，且具备抗转移能力。
T75760	GRGDSP TFA
	GRGDSP (TFA) 是一种整联蛋白 (integrin) 抑制剂。
T82642	Cyclo(RGDfK(Mal))
	Cyclo(RGDfK(Mal))为一种五肽，能促进人多能干细胞的附着与渗透，适用于三维干细胞培养及其扩增。
TP1668	CGGRGD TFA (1260223-44-6 free base) CGGRGD TFA
	CGGRGD TFA is synthesized via solid-phase peptide synthesis technique and the surface of PCL fibers is aminolysised by amino 2-cyanobenzothiazole followed by the addition of 2-cyanobenzothiazole (CBT)[1].
T82516	E(c(RGDfK))₂
	E(c(RGDfK))是一种针对αvβ3整联蛋白的特异性结合片段，表现出对肿瘤的靶向作用。在人卵巢癌OVCAR-3异种移植肿瘤模型中，该化合物的摄取有所提升，适用于癌症研究领域。
T81282	RGDV
	RGDV为血小板聚集抑制剂，能够抑制血小板依赖性血栓形成，并通过靶向效应进行肿瘤识别。
T8726	Cyclo(RGDyK)	Integrin	Cytoskeletal Signaling
	Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
TP1458L	Arg-Gly-Glu-Ser acetate(93674-97-6 free base)	Others	Others
	Arg-Gly-Glu-Ser acetate(93674-97-6 free base) 是一种 RGD 相关肽，可控制纤维蛋白原与活化血小板结合的 RGDS 活性。
T12857	SC-52012	Others	Others
	SC-52012 是一种新型有效的纤维蛋白原受体 (fibrinogen receptor) 拮抗剂，是一种 RGD 模拟物，对血小板聚集有抑制作用。
TP1330	Cyclo(RADfK)	Integrin	Cytoskeletal Signaling
	Cyclo(RADfK) 是选择性 α(v)β(3) 整合素配体，广泛用于新血管生成的研究、治疗和诊断。它是 cyclo (-RGDfK-) 的阴性对照， RGD 肽。 RGD 肽是细胞粘附的调节剂，并被整合素家族的几个成员识别。
T4286	Fmoc-Val-Ala-PAB-OH Fmoc-Val-Ala-PAB	Others; AChR	Neuroscience; Others
	Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) 是一种有用的接头，可用于制备用于靶向药物递送的抗体-药物偶联物。它还用于合成带有溶酶体可切割接头的 RGD 拟肽-紫杉醇缀合物。
TP1474	LXW7	Integrin	Cytoskeletal Signaling
	LXW7 是一种整合素αvβ3抑制剂，是含 Arg-Gly-Asp (RGD) 的环状肽，对αvβ3整联蛋白具有很高的结合亲和力，IC50为 0.68 μM。它可增强 VEGFR-2 磷酸化和 ERK1/2 活化，具有抗炎活性。
T33734	NS 11 NS-11,NS11
	NS 11 is an RGD-nonpeptidic mimetic.
T78001	Arg-Gly-Glu-Ser TFA
	Arg-Gly-Glu-Ser TFA，作为RGD相关多肽，调节RGDS对纤维蛋白原及活化血小板结合的抑制作用。
TP1355	Arg-Gly-Glu-Ser(TFA)(93674-97-6,free) Arg-Gly-Glu-Ser(TFA)
	Arg-gly-glu -Ser(TFA) is a RGD related polypeptide that controls the inhibition of fibrinogen binding to activated platelets by RGDS.
T76582	Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10)
	Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10)，为含环状RGD活性序列的十肽，作为整合素(Integrin)αIIbβ3的拮抗剂，能够抑制血小板与proMMP-13的粘附。
T80075	Cyclo(Ala-Arg-Gly-Asp-Mamb) XJ735	Integrin	Cytoskeletal Signaling
	Cyclo(Ala-Arg-Gly-Asp-Mamb) 是选择性的RGD肽拮抗剂，用于肺动脉高压治疗研究。
T24896	TP 9201 TP-9201,TP9201
	TP 9201 is a platelet integrin alphaIIbbeta3 antagonist. It is a synthetic RGD-containing cyclic peptide.
TP2148	LXW7 TFA (1313004-77-1 free base) LXW7 TFA	Integrin	Cytoskeletal Signaling
	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3 integrin (IC50: 0.68 μM). It increases the phosphorylation of VEGFR-2 and activation of ERK1/2.
T82359	G-{d-Arg}-GDSP
	G-{d-Arg}-GDSP为RGD多肽类似物，具有与整合素粘附受体结合的能力，能够抑制细胞对纤维连接蛋白的附着及破骨细胞的重吸收。
T24796	SK&F 107260 Skf107260,Skf-107260,Skf 107260
	SK&F 107260 is an RGD-containing peptide. It is a potent GP IIb/IIIa antagonist and a vitronectin antagonist.

化合物

Cat.No: T6966

Synonym: RGD (Arg-Gly-Asp) Peptides,Arg-Gly-Asp,RGD Peptides

Target: Integrin

RGD peptide (GRGDNP)

Cat.No: T7570

Synonym: RGD peptide GRGDNP(2TFA),H-甘氨酰-精氨酰-甘氨酰-天冬氨酰-天冬酰胺酰-脯氨酸-OH,RGD peptide GRGDNP

Target: Apoptosis, Integrin

Arg-Gly-Asp TFA (99896-85-2(free base))

Cat.No: T4613

Synonym: RGD Trifluoroacetate,RGD

Target: Integrin

RGD peptide (GRGDNP) (TFA) (114681-65-1 free base)

Cat.No: TP1311

Synonym: RGD peptide (GRGDNP) (TFA)

RGD Trifluoroacetate

Cat.No: TP1343

Cat.No: T76378

RGD peptide (GRGDNP) (TFA)

Cat.No: T76007

RGD-targeted Proapoptotic Peptide

Cat.No: T81283

Cat.No: T7566

Synonym: EMD 56574

Target: Others

GRGDSPK 2TFA(111119-28-9(free base))

Cat.No: T7566L

Synonym: EMD 56574

Target: Others

YRGDS Fibronectin Fragment acetate

Cat.No: TP1530L

Synonym: YRGDS Fibronectin Fragment acetate(134282-68-1 free base)

Target: Others

GRGDSP acetate(91037-75-1 free base)

Cat.No: TP1290

Synonym: GRGDSP TFA

Target: Integrin

CGGRGD acetate(1260223-44-6 free base)

Cat.No: TP1696L

Target: Others

Cyclo(-RGDyC)acetate

Cat.No: TP2484L

Target: Others

Cyclo(-RGDfC)acetate

Cat.No: TP2483L

Synonym: Cyclo(-RGDfC)acetate(862772-11-0 free base)

Target: Others

Cyclo(RGDyK) trifluoroacetate

Cat.No: T6813

Synonym: Cyclo(RGDyK)

Target: Integrin

GRGDSPC acetate

Cat.No: TP1759L

Synonym: GRGDSPC,GRGDSPC acetate(91575-26-7 free base)

Target: Others

Cyclo(-RGDfK)

Cat.No: T6812

Synonym: Cyclo (-RGDfK)

Target: Integrin

GRGDSPK acetate

Cat.No: T7566L1

Synonym: GRGDSPK acetate(111119-28-9 Free base)

Target: Beta Amyloid

Cat.No: TP1204

Synonym: c(CRGDKGPDC)

Target: Integrin

Cyclo(-RGDfK) TFA

Cat.No: T6812L

Target: Integrin

Cat.No: TP1421

Cat.No: T75765

YRGDS Fibronectin Fragment

Cat.No: TP1530

Cat.No: TP1696

cRGDfK-thioacetyl ester

Cat.No: T80214

Target: Integrin

Cat.No: T82641

Cat.No: T81284

Cat.No: TP1759

iRGD peptide 1 TFA

Cat.No: T77996

Cat.No: T75760

Cyclo(RGDfK(Mal))

Cat.No: T82642

CGGRGD TFA (1260223-44-6 free base)

Cat.No: TP1668

Synonym: CGGRGD TFA

E(c(RGDfK))₂

Cat.No: T82516

Cat.No: T81282

Cat.No: T8726

Target: Integrin

Arg-Gly-Glu-Ser acetate(93674-97-6 free base)

Cat.No: TP1458L

Target: Others

Cat.No: T12857

Target: Others

Cat.No: TP1330

Target: Integrin

Fmoc-Val-Ala-PAB-OH

Cat.No: T4286

Synonym: Fmoc-Val-Ala-PAB

Target: Others, AChR

Cat.No: TP1474

Target: Integrin

Cat.No: T33734

Synonym: NS-11,NS11

Arg-Gly-Glu-Ser TFA

Cat.No: T78001

Arg-Gly-Glu-Ser(TFA)(93674-97-6,free)

Cat.No: TP1355

Synonym: Arg-Gly-Glu-Ser(TFA)

Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge:cys1-cys10)

Cat.No: T76582

Cyclo(Ala-Arg-Gly-Asp-Mamb)

Cat.No: T80075

Synonym: XJ735

Target: Integrin

Cat.No: T24896

Synonym: TP-9201,TP9201

LXW7 TFA (1313004-77-1 free base)

Cat.No: TP2148

Synonym: LXW7 TFA

Target: Integrin

Cat.No: T82359

Cat.No: T24796

Synonym: Skf107260,Skf-107260,Skf 107260

Cat. No.	Product Name	Target	Signaling Pathways
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...

天然产物

Cat.No: T36295

Cat.No: TN5221

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