Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18639 |
Cl-C6-PEG4-O-CH2COOH
PROTAC Linker 4 |
Others | Others |
Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) 是一种有效的基于聚乙二醇的 PROTAC 连接剂,常被用于 PROTAC 合成氯烷(HaloPROTACs)。 | |||
T18614 |
Bis-Tos-PEG4
Tetraethylene glycol di(p-toluenesulfonate),PROTAC Linker 16,1,11-Bis(tosyloxy)-3,6,9-trioxaundecane |
Others; PROTAC Linker | Others; PROTAC |
Bis-Tos-PEG4 (PROTAC Linker 16) 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T14408 |
Azido-PEG1-CH2CO2H
4-哌啶酮缩乙二醇 |
Others; PROTAC Linker | Others; PROTAC |
Azido-PEG1-CH2CO2H 是属于 alkyl/ether 类的PROTAC linker,可用于合成 PROTAC BRD4 Degrader-1. | |||
T18391 |
N-Boc-4-pentyne-1-amine
|
Others; PROTAC Linker | Others; PROTAC |
N-Boc-4-pentyne-1-amine 是一种基于烷基链的PROTAC连结剂,用于PROTAC MG-277[1]的合成。 | |||
T18807 |
Thalidomide-NH-C4-NH-Boc
|
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-C4-NH-Boc 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T16658 |
Boc-NH-PEG4
PROTAC Linker 12 |
Others | Others |
Boc-NH-PEG4, also known as PROTAC Linker 12, is a PEG-based linker compound utilized for the synthesis of PROTACs[1]. | |||
T18628 |
Tos-PEG4-NH-Boc
PROTAC Linker 7 |
Others | Others |
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based linker used for the synthesis of PROTACs[1]. | |||
T15529 |
Hydroxy-PEG4-(CH2)2-Boc
丙酸叔丁酯-四聚乙二醇 |
PROTAC Linker | PROTAC |
Hydroxy-PEG4-(CH2)2-Boc 是一种不可切割的 ADC 接头,用于合成抗体-药物偶联物。它也可用作 PROTAC 接头用于 PROTAC 合成。. | |||
T17653 |
Boc-NH-C4-acid
Boc-5-氨基戊酸 |
Others; PROTAC Linker | Others; PROTAC |
Boc-NH-C4-acid 是一种属于 Alkyl/ether 类的 PROTAC linker,可用于 PROTAC1 的合成,并且可以降解 PRC2 中的 EED,EZH2,和 SUZ12。 | |||
T14271 |
Aminooxy-PEG4-alcohol
|
Others; PROTAC Linker | Others; PROTAC |
Aminooxy-PEG4-alcohol 既是不可裂解的 4 单元 PEG ADC linker,也是基于 PEG 的 PROTAC linker。 | |||
T15919 |
m-PEG7-4-nitrophenyl carbonate
|
Others; PROTAC Linker | Others; PROTAC |
m-PEG7-4-nitrophenyl carbonate 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T17326 |
2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide
2-3-4-6-tetra-o-acetyl-alpha-galactosylpyranosyl-bromide |
Others; PROTAC Linker | Others; PROTAC |
2,3,4,6-Tetra-o-acetyl-alpha-galactosylpyranosyl bromide (2-3-4-6-tetra-o-acetyl-alpha-galactosylpyranosyl-bromide) 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
T18546 |
(+)-Biotin-ONP
(+)-生物素对硝基苯酯,(+)-Biotin 4-nitrophenyl ester |
Others; PROTAC Linker | Others; PROTAC |
(+)-Biotin-ONP ((+)-Biotin 4-nitrophenyl ester) 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
FL0195 |
N-Boc-4-hydroxy-L-proline methyl ester
|
||
N-Boc-cis-4-hydroxy-L-proline methyl ester为不可降解(non-cleavable)的ADC linker,用于抗体药物偶联体(ADCs)合成。该化合物同时作为基于烷基链(alkyl chain)的PROTAC linker,适用于PROTAC合成。 | |||
T17921 |
(S,R,S)-AHPC-PEG4-N3
VH032-PEG4-N3,VHL Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 4 |
Others; PROTAC Linker | Others; PROTAC |
(S,R,S)-AHPC-PEG4-N3 (VHL Ligand-Linker Conjugates 5) is a synthesized conjugate that functions as a ligand-linker in E3 ligase-based systems. It is composed of the (S,R,S)-AHPC VHL ligand and a 4-unit PEG linker, both commonly employed in PROTAC technology. | |||
T7755 |
Thalidomide 4-fluoride
E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
IRAK; Ligand for E3 Ligase | Immunology/Inflammation; NF-κB; PROTAC |
Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接,得到 PROTAC IRAK4 degrader-1。 | |||
T9386 |
2-(2,6-dioxopiperidin-3-yl)-4-((9-hydroxynonyl)oxy)isoindoline-1,3-dione
|
Others | Others |
2-(2,6-dioxopiperidin-3-yl)-4-((9-hydroxynonyl)oxy)isoindoline-1,3-dione 是一种 PROTAC 接头,可用于 PROTAC 的合成。 | |||
T17325 |
Pomalidomide-PEG4-C-COOH
Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1 |
Others; E3 Ligase Ligand-Linker Conjugate | Others; PROTAC |
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T18595 |
Dasatinib carbaldehyde
PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde |
Others; Ligands for Target Protein for PROTAC | Others; PROTAC |
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) 基于 ABL 抑制剂达沙替尼,通过接头与 IAP 配体结合,形成 SNIPER [1]。 | |||
T40032 |
Pomalidomide-PEG4-C2-NH2 hydrochloride
|
PROTAC Linker | PROTAC |
Pomalidomide-PEG4-C2-NH2 hydrochloride 是 E3 连接酶配体和 linker 组成的 偶联物,包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG 的 linker,可用于 PROTAC 分子的合成。 | |||
T40030 |
Thalidomide 4'-ether-alkylC2-amine hydrochloride
halidomide-linker 6 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide 4'-ether-alkylC2-amine hydrochloride (halidomide-linker 6) 包含基于 Thalidomide 的 cereblon 配体和 linker,是合成的 E3 连接酶配体-linker 偶联物,可应用于 PROTAC 技术。 | |||
T17916 |
Pomalidomide-PEG4-C2-NH2
Cereblon Ligand-Linker Conjugates 8,E3 Ligase Ligand-Linker Conjugates 22 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Pomalidomide-PEG4-C2-NH2 (E3 Ligase Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体- linker 偶联物,用于 PROTAC 技术中。 | |||
T7763 |
Thalidomide-4-OH
Cereblon ligand 2,E3 ligase Ligand 2 |
Ligand for E3 Ligase | PROTAC |
Thalidomide-4-OH (E3 ligase Ligand 2) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T40016 |
Thalidomide-NH-CH2-COOH
2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine |
Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T40031 |
Thalidomide-O-C6-NH2 hydrochloride
4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride,萨力多胺-O-C6-氨基盐酸盐 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) 是一种合成的E3 连接酶配体 -linker 偶联物,用于 PROTAC dTAG-13 的合成。其中 dTAG-13 是一种 FKBP12F36V 和 BET 的降解剂。 | |||
T9401 |
Thalidomide-NH-PEG1-NH2 hydrochloride
4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T9382 |
Thalidomide-NH-C2-PEG3-OH
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是 E3 连接酶配体-linker 偶联物,可用于合成 PROTAC BCL-XL 降解剂 XZ739。 | |||
T17350 |
ACBI1
|
Apoptosis; Epigenetic Reader Domain; PROTACs | Apoptosis; Chromatin/Epigenetic; PROTAC |
ACBI1 是一种基于PROTAC 技术的 BAF ATPase 亚基SMARCA2和SMARCA4降解剂,也是 PBAF 成员PBRM1的降解剂。它由一个 bromodomain 配体、linker 和 E3 泛素连接酶von Hippel-Lindau 构成,能诱导抗增殖作用和凋亡。 | |||
T5102 |
TGN-020
TGN020 |
Aquaporin; PROTAC Linker | Membrane transporter/Ion channel; PROTAC |
TGN-020 是一种属于 alkyl chain 类的 PROTAC linker,可用于 PROTAC 的合成分子。TGN020 是一种选择性水通道蛋白 4 (AQP4) 抑制剂,IC50为 3.1 μM。TGN020 减轻大鼠脊髓压迫损伤后的水肿并抑制神经胶质瘢痕的形成。 | |||
T16167 | N-(4-Carboxycyclohexylmethyl)maleimide | Others | Others |
N-(4-Carboxycyclohexylmethyl)maleimide is an alkyl chain-based PROTAC linker suitable for synthesizing PROTACs[1]. | |||
T14239 |
Amino-PEG4-C2-amine
|
Others | Others |
Amino-PEG4-C2-amine, a PEG-based linker (4 units) for PROTAC development, facilitates the synthesis of PROTACs. | |||
T14241 |
Amino-PEG4-CH2COOH
|
Others | Others |
Amino-PEG4-CH2COOH is a PEG-based PROTAC linker and a non-cleavable 4 unit PEG ADC linker employed in the synthesis of PROTACs and antibody-drug conjugates (ADCs). | |||
T14437 |
Azido-PEG4-4-nitrophenyl carbonate
|
Others | Others |
Azido-PEG4-4-nitrophenyl carbonate, a PEG-derived PROTAC linker, enables the synthesis of PROTACs[1]. | |||
T14041 |
4-Maleimidobutyric acid
|
Others | Others |
4-Maleimidobutyric acid is an alkyl chain-derived PROTAC linker that enables the synthesis of PROTACs[1]. | |||
T14039 |
4-Bromobutylphosphonic acid
|
Others | Others |
4-Bromobutylphosphonic acid is an alkyl chain-derived PROTAC linker employed for the synthesis of PROTACs[1]. | |||
T14823 | Bromoacetamido-PEG4-acid | Others | Others |
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker utilized for PROTAC synthesis[1]. It also serves as a cleavable 4-unit PEG ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2]. | |||
T17336 |
4-(N-Boc-amino)-1,6-heptanedioic acid
|
Others | Others |
4-(N-Boc-amino)-1,6-heptanedioic acid is an alkyl/ether-based linker, suitable for PROTAC synthesis [1]. | |||
T14445 |
Azido-PEG4-C2-acid
|
Others | Others |
Azido-PEG4-C2-acid, a PEG-based PROTAC linker, is utilized in the synthesis of vRucaparib-TP4. It serves as a non-cleavable 4 unit PEG ADC linker for antibody-drug conjugate (ADC) synthesis. | |||
T18596 |
PROTAC AR Degrader-4
|
Others | Others |
PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker and an androgen receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1]. | |||
T39013 | 4-Boc-amino-2,2-dimethylbutyric acid | ||
4-Boc-amino-22-dimethylbutyric acid is an alkyl/ether-derived PROTAC linker, suitable for the synthesis of PROTACs. | |||
T18634 |
PROTAC MDM2 Degrader-4
|
Others | Others |
PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1]. | |||
T17333 | 4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol | Others | Others |
4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-derived PROTAC linker employed for the synthesis of PROTACs[1]. | |||
T17338 |
(4-Oxo-4H-quinazolin-3-yl)-acetic acid
|
Others | Others |
(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-derived PROTAC linker suitable for the synthesis of PROTACs[1]. | |||
T17896 |
cIAP1 Ligand-Linker Conjugates 4
E3 ligase Ligand-Linker Conjugates 42 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 4 is a chemical compound that comprises an IAP ligand specifically designed for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 4, has the potential to be utilized in the development of SNIPERs[1]. | |||
T14237 |
Amino-PEG4-alcohol
|
Others | Others |
Amino-PEG4-alcohol is a PEG-based PROTAC linker that can be employed for the synthesis of PROTACs[1]. It is also a non-cleavable 4 unit PEG ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[2]. | |||
T14453 |
Azido-PEG4-Val-Cit-PAB-OH
|
Others | Others |
Azido-PEG4-Val-Cit-PAB-OH is a 4-unit PEG ADC linker and a PEG-based PROTAC linker. It is employed for the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. | |||
T16583 |
Propargyl-PEG1-acid
|
Others | Others |
Propargyl-PEG1-acid, a PEG-based PROTAC linker, enables the synthesis of BTK-CRBN PROTACs, specifically Ibrutinib-based PROTAC 4 and PROTAC 5. At a concentration of 10 μM, PROTAC 5 facilitates the degradation of BTK and induces the degradation of CSK, LYN, and LAT2[1]. | |||
T40547 |
Lenalidomide-4-aminomethyl hydrochloride
|
||
Lenalidomide-4-aminomethyl hydrochloride is a compound derived from Lenalidomide, serving as a cereblon (CRBN) ligand for the recruitment of CRBN protein. By connecting Lenalidomide-4-aminomethyl hydrochloride to the ligand via a linker, PROTAC formation can be facilitated. | |||
T15871 |
m-PEG4-Boc
|
Others | Others |
m-PEG4-Boc is a cleavable 4-unit polyethylene glycol (PEG) linker, widely employed in the synthesis of antibody-drug conjugates (ADCs) [1]. Additionally, m-PEG4-Boc serves as a PEG-based PROTAC linker, enabling its utilization in the synthesis of PROTACs [2]. | |||
T36262 |
Thalidomide-NH-C5-NH2 hydrochloride
Pomalidomide 4'-alkylC5-amine |
||
Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC5 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 4 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. |