Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9066 |
Merafloxacin
CI 934 |
SARS-CoV | Microbiology/Virology |
Merafloxacin (CI 934) 是一种氟喹诺酮类抗菌药物,也被确定为 SARS-CoV-2 的 1 PRF 抑制剂。它对革兰氏阳性菌和革兰氏阴性菌具有体外活性。 | |||
T3132 |
SC66
|
Apoptosis; Akt | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
SC66 是一种Akt 抑制剂,可降低细胞活力。它以剂量和时间依赖性地抑制肝癌细胞的集落形成和诱导凋亡。 | |||
T36668 | Geranylgeranoic Acid | ||
Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also... | |||
T6345 |
Tirbanibulin
KX2-391,KX-01 |
Microtubule Associated; Src | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Tirbanibulin (KX2-391) 是一种高度选择性的 Src 激酶抑制,靶向 Src 的多肽底物结合位点,对多种癌症有疗效。 | |||
T15675 |
Tirbanibulin Mesylate
KX2-391 Mesylate,KX01 Mesylate |
Microtubule Associated; Src | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Tirbanibulin Mesylate (KX01 Mesylate) 是一种 Src 抑制剂,靶向 Src 的肽底物位点。在肿瘤细胞中,GI50值为 9-60 nM。 | |||
T15674 |
Tirbanibulin dihydrochloride
KX-01 (dihydrochloride),KX2-391 (dihydrochloride) |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines). |