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Search Results for " pku "

Targets Recommended: Dehydrogenase

5

抑制剂 & 化合物

4

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T28424	PKUMDL-WQ-2101	Dehydrogenase	Metabolism
	PKUMDL-WQ-2101 是磷酸甘油酸脱氢酶的选择性变构抑制剂，具有抗肿瘤活性。
T36935	PKUMDL-LC-101-D04 GPX4-Activator-1d4,PKUMDL-LC-101-D04	GPX	oxidation-reduction
	PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4（GPX4）的异位激活剂，是一种铁死亡的调节剂。当在无细胞试验中使用浓度为20 μM 时，GPX4活性增加到对照水平的150%；在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时，GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04（200 μM）能减少胆固醇过氧化氢诱导的MEF 死亡。
T28423	PKUMDL-LTQ-301
	PKUMDL-LTQ-301 is a potent inhibitor of HipA toxin. PKUMDL-LTQ-301 also inhibits E. coli persistence.
T28425	PKUMDL-WQ-2201
	PKUMDL-WQ-2201 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) with Anti-tumor Activity, it binds to site II.
T82004	JNT-517
	JNT-517（Example 352）为口服活性SLC6A19变构抑制剂，可应用于苯丙酮尿症（PKU）研究。

化合物

PKUMDL-WQ-2101

Cat.No: T28424

Target: Dehydrogenase

PKUMDL-LC-101-D04

Cat.No: T36935

Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04

Target: GPX

PKUMDL-LTQ-301

Cat.No: T28423

PKUMDL-WQ-2201

Cat.No: T28425

Cat.No: T82004

Cat. No.	Product Name	Target	Signaling Pathways
T7117	Sapropterin dihydrochloride Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤	Hydroxylase	Metabolism
	Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。
T5251	Phenylpyruvic acid 2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸	Others; Endogenous Metabolite	Metabolism; Others
	Phenylpyruvic acid (3-Phenylpyruvic acid) 可以通过乳酸脱氢酶合成3-苯基乳酸 (PLA)。
T5290	(S)-2-Hydroxy-3-phenylpropanoic acid L-(−)-3-Phenyllactic acid,L-3-苯乳酸	Others; Endogenous Metabolite	Metabolism; Others
	(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。
T5308	2-Hydroxyphenylacetic acid Ortho-Hydroxyphenylacetic acid,邻羟基苯乙酸,2-HPAA,2-Hydroxybenzeneacetic Acid	Others; Endogenous Metabolite	Metabolism; Others
	2-Hydroxyphenylacetic acid (Ortho-Hydroxyphenylacetic acid) 是一种食物的潜在生物标记，被发现和苯丙酮尿症(PKU)相关。

天然产物

Sapropterin dihydrochloride

Cat.No: T7117

Synonym: Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤

Target: Hydroxylase

Phenylpyruvic acid

Cat.No: T5251

Synonym: 2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid,苯丙酮酸

Target: Others, Endogenous Metabolite

(S)-2-Hydroxy-3-phenylpropanoic acid

Cat.No: T5290

Synonym: L-(−)-3-Phenyllactic acid,L-3-苯乳酸

Target: Others, Endogenous Metabolite

2-Hydroxyphenylacetic acid

Cat.No: T5308

Synonym: Ortho-Hydroxyphenylacetic acid,邻羟基苯乙酸,2-HPAA,2-Hydroxybenzeneacetic Acid

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02707	PAH Protein, Human, Recombinant (415 Asn/Asp, His) phenylalanine hydroxylase,PH,PKU1,PKU	Human	Baculovirus Insect Cells
	PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg...
TMPY-04401	TLK2 Protein, Human, Recombinant (aa 397-772) HsHPK,PKU-ALPHA,PKU-α,tousled-like kinase ...	Human	Baculovirus Insect Cells
	TLK2 Protein, Human, Recombinant (aa 397-772) is expressed in Baculovirus insect cells. The predicted molecular weight is 43.6 kDa and the accession number is Q86UE8-1.
TMPY-04400	TLK2 Protein, Human, Recombinant (aa 397-772, His & GST) PKU-α,tousled-like kinase 2,HsHPK,PKU-ALPH...	Human	Baculovirus Insect Cells
	TLK2 Protein, Human, Recombinant (aa 397-772, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 71.3 kDa and the accession number is Q86UE8-1.
TMPY-04420	TLK1 Protein, Human, Recombinant (His & GST) KIAA0137,PKU-beta,tousled like kinase 1,PKU	Human	Baculovirus Insect Cells
	Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper chromosome segregation and maintenance of diploid cells at mitosis in mammalian cells that could be mediated by reduced phosphorylation of histone H3 and condensation of chromosomes, although other explanations to the phenotype are possible.

重组蛋白

PAH Protein, Human, Recombinant (415 Asn/Asp, His)

Cat.No: TMPY-02707

Species: Human

Expression System: Baculovirus Insect Cells

TLK2 Protein, Human, Recombinant (aa 397-772)

Cat.No: TMPY-04401

Species: Human

Expression System: Baculovirus Insect Cells

TLK2 Protein, Human, Recombinant (aa 397-772, His & GST)

Cat.No: TMPY-04400

Species: Human

Expression System: Baculovirus Insect Cells

TLK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04420

Species: Human

Expression System: Baculovirus Insect Cells

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