Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61700 |
PIM1-IN-7
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PIM1-IN-7 (compound 6c) is a powerful inhibitor of PIM-1, effectively suppressing its activity with an IC50 of 0.67 μM. This compound also exhibits significant cytotoxicity against HCT-116 and MCF-7 cells, as demonstrated by their respective IC50 values of 42.9 and 7.68 μM [1]. | |||
T3352 |
XL413
|
cholecystokinin; Casein Kinase; Pim; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; JAK/STAT signaling; Metabolism; Stem Cells |
XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂,具有潜在的抗肿瘤活性,IC50值为 3.4 nM。它对 pMCM 的 EC50值为 118 nM,对 CK2 和 PIM1 的 IC50值分别为 215 和 42 nM。 | |||
T12474 |
PIM1-IN-1
|
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity. | |||
T62188 |
PIM1-IN-6
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PIM1-IN-6 (compound 5h) 是一种 PIM-1 的有效抑制剂 (IC50: 0.60 μM)。PIM1-IN-6 对 HCT-116 和 MCF-7 细胞具有较高的细胞毒作用,他们的 IC50 值分别为 1.51 和 15.2 μM。 |