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Cat. No.	Product Name	Target	Signaling Pathways
T8659	K-Ras-PDEδ-IN-1	PDE	Metabolism
	K-Ras-PDEδ-IN-1 是新型的 K-Ras-PDEδ 抑制剂，它能够以低纳摩尔Kd8 nM 与 PDEδ 的法尼基结合袋竞争性结合。
T32419	KRAS4b-PDEδ stabilizer C19
	KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via decreased activation of oncogenic KRAS4b signaling.
T10201	PDE IV-IN-1	PDE	Metabolism
	PDE IV-IN-1 是一种有效的磷酸二酯酶4 (PDE4)抑制剂，具有抗炎活性，可用于治疗哮喘，慢性阻塞性肺病和其他炎症性疾病，是研究抑郁症的潜在化合物。
T12395	PDE9-IN-1	PDE	Metabolism
	PDE9-IN-1 是一种选择性和口服生物可利用的 PDE9A 抑制剂（IC50 为 8.7 nM）。
T67941	PDE5-IN-9
	PDE5-IN-9对Phosphodiesterase PDE1c 具有抑制作用，可用来治疗高血压、心力衰竭、心肌梗塞、肾衰竭、哮喘、支气管炎和痴呆。
T36832	PDE4B-IN-2 A 33	PDE	Metabolism
	PDE4B-IN-2 (A 33) 是一种具有口服活性，选择性 PDE4B 抑制剂，IC50 为 15 nM。PDE4B-IN-2 抑制 PDE4D (IC50=1.7 µM)。PDE4B-IN-2 表现出有效的抗炎作用。
T39210	PDE4-IN-4 PDE4-IN-4
	PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of pulmonary diseases.
T40356	PDE4-IN-3 PDE4-IN-3
	PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.
T40278	PDE2A-IN-1 PDE2A-IN-1
	PDE2A-IN-1 is a phosphodiesterase 2A (PDE2A) inhibitor with an IC 50 value of 1.3 nM.
T39796	PDE12-IN-1 PDE12-IN-1
	PDE12-IN-1 is a powerful and specific inhibitor of PDE12, exhibiting a pIC 50 value of 9.1 for enzyme inhibition. It effectively enhances levels of 2′,5′-linked adenylate polymers (2-5A), with a pEC 50 value of 7.7. Additionally, PDE12-IN-1 demonstrates antiviral activity.
T62900	PDE10-IN-5
	PDE10-IN-5 是一种磷酸二酯酶 10 (PDE 10) 抑制剂，能够用于研究某些中枢神经系统疾病。
T62969	PDE4-IN-6
	PDE4-IN-6 是一种安全的、有效的、中等选择性的 PDE4 抑制剂，作用于 PDE4B (IC50: 0.125 μM) 和 PDE4D (IC50: 0.43 μM)。PDE4-IN-6 能够下调 TNF-α 和 IL-6 的表达水平，表现出抗炎、抗关节炎作用，并具有强大的免疫调节活性。PDE4-IN-6 具有潜力进行抗类风湿性关节炎的研究。
T22491	PDE7-IN-2	PDE	Metabolism
	PDE7-IN-2 是磷酸二酯酶 7 (IC50 = 2.1 µM) 的抑制剂，可用于帕金森病研究。
T63776	PDE1-IN-4
	PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂，能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷)，表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。
T61333	PDE11-IN-1
	PDE11-IN-1 是一种PDE11抑制剂，可用于肾上腺机能不全的研究。
T61208	PDE4-IN-11
	PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory airway diseases [1] [2] [3].
T79385	PDE1-IN-5
	PDE1-IN-5 (Compound 10c) 是一种PDE1C选择性抑制剂，IC50为15 nM。该化合物显示出抗炎活性，能够抑制LPS诱导的iNOS、TNF-α、IL-1α、IL-1β和IL-6表达。在DSS诱导的结肠炎小鼠模型中，PDE1-IN-5对抗炎性肠病(IBD)表现出治疗潜力，并可用于IBD相关研究。
T73240	PDE5-IN-4
	PDE5-IN-4为磷酸二酯酶5（PDE5）抑制剂，应用于急性心肌梗死及再灌注损伤、消化系统疾病、糖尿病相关损害及肝功能衰竭的研究。
T68191	PDE-I2
	PDE-I2 is a parasite schizogony inhibitor.
T81533	PDE5-IN-11
	PDE5-IN-11为一种有效PDE5抑制剂，IC50值为40 nM。该化合物对PDE4与PDE6也表现出抑制作用，其IC50值分别为1.78 μM和0.09 μM。
T78559	PDE7-IN-3
	PDE7-IN-3（例2）是一种具有潜在镇痛活性的PDE7磷酸二酯酶抑制剂，可用于探究炎性、神经性、内脏性及伤害性疼痛。
T79624	PDE4-IN-14
	PDE4-IN-14 (化合物1)是PDE4抑制剂，适用于研究与PDE4关联的疾病（例如炎症性和免疫性疾病、癌症及代谢性疾病等）。
T60934	PDE4-IN-9
	PDE4-IN-9 (Compound 5j) 是 PDE4的有效抑制剂。在体外酶学测定结果表明，PDE4-IN-9 对 PDE4 的IC50值为1.4 μM ，低于母体咯利普兰的2.0 μM。PDE4-IN-9 在 LPS 诱导的哮喘/COPD 和脓毒症动物模型中也表现出良好的体内活性。
T79538	PDE4-IN-13
	PDE4-IN-13 is a phosphodiesterase 4 inhibitor with an IC50 value of 1.56 μM, exhibiting anti-inflammatory and antioxidative properties. It is utilized in the study of chronic obstructive pulmonary disease (COPD).
T79533	PDE5-IN-10
	PDE5-IN-10 (compound 4b)，一有效PDE5抑制剂，IC50值为20 nM。该化合物体外微粒体稳定性增强（t1/2= 44.6 分钟），在长期增强恢复方面效果显著，适用于阿尔茨海默病（AD）研究。
T60920	PDE4-IN-8
	PDE4-IN-8 (Example 5) 是磷酸二酯酶4(PDE4)的有效抑制剂。PDE4-IN-8 对 PDE4B2 的 IC50值为 0.93 nM。然而，PDE4-IN-8 对 IL13、IL4、IFNy 的抑制作用微弱，IC50值分别为 4.04 nM, 36.33 nM, 2394 nM。
T60346	PDE4-IN-10
	PDE4-IN-10 (compound 7a) 是一种有效的PDE4抑制剂，其对PDE4B 的IC50值为 7.01 μM。PDE4-IN-10 表现出选择性，微粒体稳定性，对TNF-α有抑制作用，并且在体外无明显毒性。
T61295	PDE4-IN-5
	PDE4-IN-5 (compound 33a) is a highly potent and selective inhibitor of the enzyme PDE4, with an IC50 value of 3.1 nM. It exhibits excellent skin permeability and its binding mechanism has been extensively characterized. Additionally, PDE4-IN-5 demonstrates a notable anti-psoriasis effect [1].
T63912	PDE4-IN-12
	PDE4-IN-12 是强效的、安全性良好的 PDE4 泛型抑制剂，能够作用于 PDE4 (IC50: 3.5 nM, SI: 2.71) 和 PDE7 (IC50: 15 nM, SI: 4.27)。PDE4-IN-12 能够用于研究炎症性肠病 (IBDs)。
T62681	PDE5-IN-3
	PDE5-IN-3 (compound 11j) 是一种 PDE5 的有效抑制剂 (IC50: 1.57 nM)。PDE5-IN-3 对 EGFR 具有中度抑制作用 (IC50: 5.827 μM)。PDE5-IN-3 明显抑制 Wnt/β-catenin 通路，其 IC50 值为 1286.96 ng/mL。PDE5-IN-3 在 HepG2 细胞中诱导内在的凋亡线粒体途径。PDE5-IN-3 表现出显著的抗肿瘤效果。
T70064	PDE1-IN-1
	PDE1-IN-1can enhance levels of the second messengers cAMP/cGMP leading to the expression of neuronal plasticity-related genes, neurotrophic factors, and neuroprotective molecules. These neuronal plasticity enhancement properties make PDE1 inhibitors good candidates as therapeutic agents in many neurological conditions.
T63191	PDE5-IN-5
	PDE5-IN-5 是选择性的磷酸二酯酶5(PDE5)抑制剂(IC50: 2.0 nM)。
T81534	PDE11A4-IN-1
	PDE11A4-IN-1 (compound 23b) 是一种选择性的 PDE11A4 抑制剂，具有 12 nM 的 IC50。该化合物相对于 PDE1、PDE2、PDE7、PDE8 和 PDE9 显示出较高的选择性。
T64005	PDE4B-IN-3
	PDE4B-IN-3 是 PDE4B 的有效抑制剂 (IC50: 0.94 μM)，表现出抗炎作用。
T63907	PDE5/HDAC-IN-1
	PDE5/HDAC-IN-1 是磷酸二酯酶 5 (PDE5) 和 HDAC 的有效抑制剂，他们的 IC50 值分别为 46.3 nM 和 14.5 nM。PDE5/HDAC-IN-1 能够诱导细胞凋亡（apoptosis），表现出抗癌效果。
T61620	AChE/PDE4-IN-1
	AChE/PDE4-IN-1 (compound 12c) is a highly effective and specific dual inhibitor of PDE4 and AChE, with IC50 values of 0.28 μM and 1.88 μM for AChE and PDE4D, respectively. This compound demonstrates notable potential in reducing neuroinflammation associated with Alzheimer's disease research [1].
T79618	M3/PDE4 modulator-1
	M3/PDE4 modulator-1 (10f) 为多功能化合物，具备M3mAChR拮抗和PDE4抑制作用。于OVA大鼠模型中，M3/PDE4 modulator-1 (10-1000 nM/kg；iv) 能降低半胱氨酸嗜酸性粒细胞内流。
T62303	PDE4B/7A-IN-1
	化合物22是一种1安/5-羟丁腈橡胶7受体拮抗剂（5-HT1a ki=8 nm, kb=0.04 nm；5-nitrile rubber 7K i=451 nm, kb=460 nm），同时具备PDE4B/PDE7A抑制活性（PDE4B IC50= 80.4 μM；PDE7A IC50= 151.3 μM）。该化合物在体外展现出了优秀的生物膜被动穿透能力和高代谢稳定性。进一步的药理学评估揭示，22在大鼠行为测试中展现了显著的认知改善和抗抑郁效果。
T62064	PDE4B/7A-IN-2
	5-HT1A/5-HT7受体拮抗剂（5-HT1A Ki=8 nM，Kb=0.04 nM；5-HT7 Ki=451 nM，Kb=460 nM）具有 PDE4B/PDE7A 抑制活性（PDE4BIC50=80.4μM；PDE7AIC50=151.3μM），其抗抑郁样作用强于作为参考活性分子的依西酞普兰。
T6462	Deltarasin	PDE; Ras	GPCR/G Protein; MAPK; Metabolism
	Deltarasin 是一种 KRAS-PDEδ 相互作用的小分子抑制剂，与纯化的 PDEδ 结合，Kd 值为 38 nM。
T10994L2	Deltasonamide 2 (TFA)	PDE	Metabolism
	Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
T10994	Deltasonamide 2	PDE	Metabolism
	Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
T10994L	Deltasonamide 2 hydrochloride Deltasonamide 2 hydrochloride (2088485-34-9 free base)	PDE	Metabolism
	Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.
T23977	Deltazinone
	Deltazinone is a selective PDEδ inhibitor. Deltazinone exhibits less unspecific cytotoxicity and demonstrates a high correlation with the phenotypic effect of PDEδ knockdown in a set of human pancreatic cancer cell lines.
T70646	Deltarasin HCl
	Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. The anti-cancer cell activity of deltarasin can be enhanced by simultaneously blocking tumor protective" autophagy
T38920	Atrovastatin-PEG3-FITC Atrovastatin-PEG3-FITC
	Atrovastatin-PEG3-FITC (compound S31) functions as a ligand in fluorescence anisotropy assay. Its primary role is as a KRAS-PDEδ interaction inhibitor.
T71717	KRAS4b-IN-D14
	KRAS4b-IN-D14 is a specific inhibitor of oncogenic KRAS4b signaling which stabilizes the KRAS4b-PDEδ complex and remarkably decreases tumor size and triggered apoptosis of tumor cells.

化合物

K-Ras-PDEδ-IN-1

Cat.No: T8659

Target: PDE

KRAS4b-PDEδ stabilizer C19

Cat.No: T32419

Cat.No: T10201

Target: PDE

Cat.No: T12395

Target: PDE

Cat.No: T67941

Cat.No: T36832

Synonym: A 33

Target: PDE

Cat.No: T39210

Synonym: PDE4-IN-4

Cat.No: T40356

Synonym: PDE4-IN-3

Cat.No: T40278

Synonym: PDE2A-IN-1

Cat.No: T39796

Synonym: PDE12-IN-1

Cat.No: T62900

Cat.No: T62969

Cat.No: T22491

Target: PDE

Cat.No: T63776

Cat.No: T61333

Cat.No: T61208

Cat.No: T79385

Cat.No: T73240

Cat.No: T68191

Cat.No: T81533

Cat.No: T78559

Cat.No: T79624

Cat.No: T60934

Cat.No: T79538

Cat.No: T79533

Cat.No: T60920

Cat.No: T60346

Cat.No: T61295

Cat.No: T63912

Cat.No: T62681

Cat.No: T70064

Cat.No: T63191

Cat.No: T81534

Cat.No: T64005

Cat.No: T63907

Cat.No: T61620

M3/PDE4 modulator-1

Cat.No: T79618

Cat.No: T62303

Cat.No: T62064

Cat.No: T6462

Target: PDE, Ras

Deltasonamide 2 (TFA)

Cat.No: T10994L2

Target: PDE

Deltasonamide 2

Cat.No: T10994

Target: PDE

Deltasonamide 2 hydrochloride

Cat.No: T10994L

Synonym: Deltasonamide 2 hydrochloride (2088485-34-9 free base)

Target: PDE

Cat.No: T23977

Cat.No: T70646

Atrovastatin-PEG3-FITC

Cat.No: T38920

Synonym: Atrovastatin-PEG3-FITC

Cat.No: T71717

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