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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T12006	Metarrestin ML246	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Metarrestin (ML246) 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂，可有效抑制转移。Metarrestin 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录，部分是通过与翻译延伸因子 eEF1A2 的相互作用。
T8800	NSAH 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂，无细胞 IC50 为 32 μM，基于细胞的 IC50 约为 250 nM。
T6823	E3330	HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活，可以抑制癌细胞的生长和迁移，具有抗癌活性。
T11593	I-OMe-Tyrphostin AG 538 I-OMe-AG 538	IGF-1R; PI3K	PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	I-OMe-Tyrphostin AG 538是一种特异性 IGF-1R 抑制剂和 PI5P4Kα的 ATP 竞争性抑制剂（IC50：1 µM）。I-OMe-Tyrphostin AG 538可抑制 IGF-1R 介导的信号传导，并对营养缺乏的 PANC1细胞具有优先细胞毒性。
T68981	PD-321852
	PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to >30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cd...

化合物

Metarrestin

Cat.No: T12006

Synonym: ML246

Target: DNA/RNA Synthesis

NSAH

Cat.No: T8800

Synonym: 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

Target: DNA/RNA Synthesis

E3330

Cat.No: T6823

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

I-OMe-Tyrphostin AG 538

Cat.No: T11593

Synonym: I-OMe-AG 538

Target: IGF-1R, PI3K

Cat. No.	Product Name	Target	Signaling Pathways
TN2967	Pinobanksin 3-acetate 3-O-Acetylpinobanksin	Others; Antioxidant	Others; oxidation-reduction
	Pinobanksin 3-acetate (3-O-Acetylpinobanksin) 是一种短叶松素酯衍生物,是一种强抗氧化剂，存在于向日葵和蜂蜜中，可以抑制低密度脂蛋白的过氧化.