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Search Results for " p38γ "

Targets Recommended: p38 MAPK

22

抑制剂 & 化合物

1

TargetMol 试剂盒

5

重组蛋白

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Cat. No.	Product Name	Form	Specificity Of Inhibition
CL0118	p38 inhibitor kit p38 inhibitor kit

TargetMol 试剂盒

p38 inhibitor kit

Cat.No: CL0118

Cat. No.	Product Name	Target	Signaling Pathways
T81441	PLK1/p38γ-IN-1	p38 MAPK	MAPK
	PLK1/p38γ-IN-1（化合物14）为PLK1与p38γ多靶点抑制剂，体外有效抑制人肝细胞癌与肝母细胞瘤细胞增殖。
T67944	p38 MAP Kinase Inhibitor Ⅵ	p38 MAPK	MAPK
	p38 MAP Kinase Inhibitor Ⅵ是一种有效的p38 MAP Kinase 抑制剂，具有抗炎活性。
T78652	p38α inhibitor 4	p38 MAPK	MAPK
	p38α inhibitor 4 是一种选择性 MAPK p38α抑制剂，看而用于研究糖尿病、疼痛和慢性炎症。
T67830	p38α inhibitor 3	p38 MAPK	MAPK
	p38α inhibitor 3是一种丝裂原活化蛋白激酶P38α的抑制剂，可以有效阻断成肌细胞分化。
T36010	p38 MAPK Inhibitor	p38 MAPK	MAPK
	p38 MAPK Inhibitor 是p38 MAPK 激酶的有效抑制剂（IC50＝ 35 nM）。p38 MAPK Inhibitor 抑制癌基因RAS 诱导的衰老。
T36012	p38α inhibitor 2
	p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1]. [1]. Raubo P, et al. The discovery and evaluation of 3-amino-2(1H)-pyrazinones as a novel series of selective p38α MAP kinase inhibitors [published online ahead of pr...
T36011	p38 MAP Kinase Inhibitor IV p38 MAPK Inhibitor IV
	p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
T35420	(S)-p38 MAPK Inhibitor III (S)-p38 MAPK Inhibitor III
	(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively).
T61803	p38 MAPK-IN-3
	p38 MAPK-IN-3 (Compound 2c) is a potent inhibitor of p38α MAPK, displaying antitumor properties by promoting apoptosis and increasing reactive oxygen species (ROS) production [1].
T79028	p38 Kinase inhibitor 4	p38 MAPK	MAPK
	p38 Kinase inhibitor 4 (compound 135) 是高效的 p38 MAP Kinase 抑制剂，具有显著的生物活性。
T6089	Neflamapimod VX-745	p38 MAPK; Autophagy	Autophagy; MAPK
	Neflamapimod (VX-745) 是一种可穿过血脑屏障的，高选择性的p38α抑制剂，对 p38α 的IC50值为 10 nM，p38β 的IC50值为 220 nM。它对 p38β 的特异性高 22 倍，具有抗炎活性。
T16812	RWJ-67657 JNJ 3026582	p38 MAPK	MAPK
	RWJ-67657 (JNJ 3026582) 是一种可口服的选择性p38α和p38β抑制剂，IC50分别为 1 和 11 μM。它是心脏保护剂，具有抗炎和抗肿瘤活性。
T6927	Pamapimod R1503,帕吡莫德,Ro4402257	p38 MAPK; Autophagy	Autophagy; MAPK
	Pamapimod (R1503) 是一种新型的选择性 p38 丝裂原活化蛋白激酶抑制剂，对于p38α和p38β的IC50分别为 14 nM 和 480 nM，Ki 分别为 1.3 nM 和 120 nM，对 p38δ 或 p38γ 亚型没有活性，可研究类风湿关节炎和其他自身免疫性疾病。
T10298L	AMG-548	p38 MAPK	MAPK
	AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM
T18682	SJFδ	Others	Others
	SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
T10298	AMG-548 hydrochloride (864249-60-5 free base) AMG-548 hydrochloride	p38 MAPK	MAPK
	AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).
T63371	AMG-548 hydrochloride
	AMG-548 hydrochloride 是选择性的、口服具有活力的 p38α 抑制剂，Ki 值为 0.5 nM，对p38β略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有高于1000 倍的选择性。AMG 548 hydrochloride 同时能够有效抑制全血 LPS 刺激的TNFα，IC50值为 3 nM。AMG-548 hydrochloride 能够直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε ，进而对 Wnt 信号传导具有抑制作用。
T63762	AMG-548 dihydrochloride
	AMG-548 dihydrochloride 是选择性的、口服具有活力的 p38α 抑制剂，Ki 值为 0.5 nM，对 p38β略有选择性 (Ki=36 nM) 并且对 p38γ 和 p38δ 具有 >1000 倍的选择性。AMG-548 dihydrochloride 对全血 LPS 刺激的 TNFα 表现出抑制作用，IC50 值为 3 nM。AMG-548 dihydrochloride 能够直接抑制酪蛋白激酶 1 (Casein kinase 1) 同种型 δ 和 ε ，并抑制 Wnt 信号传导。
T10298L2	AMG-548 dihydrochloride (864249-60-5 free base) AMG-548 dihydrochloride	p38 MAPK	MAPK
	AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulate
T36260	NR 7h
	Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo.
T70638	p38-α MAPK-IN-5
	p38-α MAPK-IN-5 是一种有效的 p38α抑制剂，对 p38α、p38 β、p38γ、p38δ 的 IC50分别为 0.1 nM、0.2 nM、944 nM、4100 nM。p38-α MAPK-IN-5 具有抗炎作用，并且具有用于哮喘和慢性阻塞性肺病 (COPD) 研究的潜力。
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c...

化合物

PLK1/p38γ-IN-1

Cat.No: T81441

Target: p38 MAPK

p38 MAP Kinase Inhibitor Ⅵ

Cat.No: T67944

Target: p38 MAPK

p38α inhibitor 4

Cat.No: T78652

Target: p38 MAPK

p38α inhibitor 3

Cat.No: T67830

Target: p38 MAPK

p38 MAPK Inhibitor

Cat.No: T36010

Target: p38 MAPK

p38α inhibitor 2

Cat.No: T36012

p38 MAP Kinase Inhibitor IV

Cat.No: T36011

Synonym: p38 MAPK Inhibitor IV

(S)-p38 MAPK Inhibitor III

Cat.No: T35420

Synonym: (S)-p38 MAPK Inhibitor III

Cat.No: T61803

p38 Kinase inhibitor 4

Cat.No: T79028

Target: p38 MAPK

Cat.No: T6089

Synonym: VX-745

Target: p38 MAPK, Autophagy

Cat.No: T16812

Synonym: JNJ 3026582

Target: p38 MAPK

Cat.No: T6927

Synonym: R1503,帕吡莫德,Ro4402257

Target: p38 MAPK, Autophagy

Cat.No: T10298L

Target: p38 MAPK

Cat.No: T18682

Target: Others

AMG-548 hydrochloride (864249-60-5 free base)

Cat.No: T10298

Synonym: AMG-548 hydrochloride

Target: p38 MAPK

AMG-548 hydrochloride

Cat.No: T63371

AMG-548 dihydrochloride

Cat.No: T63762

AMG-548 dihydrochloride (864249-60-5 free base)

Cat.No: T10298L2

Synonym: AMG-548 dihydrochloride

Target: p38 MAPK

Cat.No: T36260

p38-α MAPK-IN-5

Cat.No: T70638

Cat.No: T68321

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04430	p38 gamma/MAPK12 Protein, Human, Recombinant mitogen-activated protein kinase 12,SAPK-3,P38 γ/MAPK12,SAPK...	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.
TMPY-04429	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) ERK3,SAPK3,PRKM12,ERK6,P38γ,P38GAMMA,mitogen-activa...	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778.
TMPY-04260	p38 Protein, Human, Recombinant (His) mitogen-activated protein kinase 14,CSPB1,PRKM14,RK,p38α,CSB...	Human	Baculovirus Insect Cells
	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ...
TMPY-04551	p38 delta/MAPK13 Protein, Human, Recombinant (GST) MAPK13,p38δ,PRKM13,MAPK-13,mitogen-activated protein kinase ...	Human	Baculovirus Insect Cells
	p38 delta/MAPK13 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68.4 kDa and the accession number is O15264.
TMPY-04531	p38 delta/MAPK13 Protein, Human, Recombinant (GST), Activated in vitro P38 δ/MAPK13,MAPK13,PRKM13,MAPK-13,p38δ,p38delta,mitogen-act...	Human	Baculovirus Insect Cells
	p38 delta/MAPK13 Protein, Human, Recombinant (GST), Activated in vitro is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68.4 kDa and the accession number is O15264.

重组蛋白

p38 gamma/MAPK12 Protein, Human, Recombinant

Cat.No: TMPY-04430

Species: Human

Expression System: Baculovirus Insect Cells

p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04429

Species: Human

Expression System: Baculovirus Insect Cells

p38 Protein, Human, Recombinant (His)

Cat.No: TMPY-04260

Species: Human

Expression System: Baculovirus Insect Cells

p38 delta/MAPK13 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04551

Species: Human

Expression System: Baculovirus Insect Cells

p38 delta/MAPK13 Protein, Human, Recombinant (GST), Activated in vitro

Cat.No: TMPY-04531

Species: Human

Expression System: Baculovirus Insect Cells

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